Sudden cardiac death in cardiomyoptahies: incidence, risk factors and prevention. AV, atrioventricular; CMR, cardiac magnetic resonance; CRT, cardiac resynchronization therapy; CV, cardiovascular; FLNC, filamin C; GDMT, guideline-directed medical therapy; HCM, hypertrophic cardiomyopathy; HFrEF, heart failure with reduced ejection fraction; ICD, implantable cardioverter-defibrillator; LGE, late gadolinium enhancement; LMNA, lamin A/C; LV, left ventricular; LVEF, left ventricular ejection fraction; NSVT, non-sustained ventricular tachycardia; NYHA, New York Heart Association; OMT, optimal medical therapy; PES, programmed electrical stimulation; PLN, phospholamban; RBM20, RNA-binding motif protein 20; RV, right ventricular; SCD, sudden cardiac death; VT, ventricular tachycardia. *Syncope, LGE on CMR, inducible sustained VT at PES, pathogenic mutations in LMNA, PLN, FLNC, and RBM20. **Significant LGE at CMR; LVEF <50%; abnormal blood pressure response during exercise test; LV apical aneurysm; high-risk genotype.

Mineralocorticoid receptor antagonist (MRA) use in severe chronic kidney disease and heart failure with reduced ejection fraction (HFrEF). CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio.

Impact of COVID-19 in patients with heart failure (HF) and mildly reduced and preserved ejection fraction. AE, adverse event; DAE, adverse events leading to discontinuation of study drug; DKA, diabetic ketoacidosis; IP, investigational product; SAE, serious adverse event. [Correction added on 15 January 2024, after first online publication: list of abbreviations have been added in this version.]

Retrospective analysis of the erythropoietic response after intravenous iron (Fe) treatment in heart failure with reduced ejection fraction (HFrEF) patients in sodium–glucose cotransporter 2 inhibitor (SGLT2i) users and non-users. CKD, chronic kidney disease; CI, confidence interval; Hb, haemoglobin; Htc, haematocrit; Sat, saturation. [Correction added on 15 January 2024, after first online publication: the graphical abstract caption and abbreviations have been corrected in this version.]

In patients randomized to a strategy of early intensive and sustained vasodilatation or usual care, the combined primary endpoint showed a significant interaction of treatment strategy and sex. Women randomized to intervention significantly more often experienced the combined endpoint when comapred to standard of care. AHF, acute heart failure. [Correction added on 15 January 2024, after first online publication: abbreviation has been added in this version.]

Exercise training in patients with advanced heart failure and left ventricular assist device (Ex-VAD) trial. 6MWT, 6-min walk test; KCCQ, Kansas City Cardiomyopathy Questionnaire physical domain score; peakVO₂, peak oxygen consumption; RCT, randomized controlled trial.

This 2023 Cochrane review of 60 randomized trials in 8728 heart failure patients, confirms the benefits of participation in exercise-based cardiac rehabilitation (ExCR), including reduced risk of hospitalization and a clinically meaningful improvement in health-related quality of life. Leveraging on the development of alternative modes of rehabilitation delivery with the COVID-19 pandemic, we provide a contemporary evidence base to demonstrate patient outcome benefits of ExCR programmes whether delivered in home and digitally supported or centre-based (or hybrid) settings. MLWHF, Minnesota Living with Heart Failure Questionnaire. *Relative risk <1.0 indicates reduced risk of event in favour of ExCR. **Mean difference of <0.0 indicates improvement in MLWHF total score in favour of ExCR. ***Interaction p > 0.05 indicates no significant difference in ExCR effect across centre, home, and hybrid mode of delivery trials.

BNP, CMR-LVEF and SUVmax in FDG-PET: independent predictors of outcome in a contemporary cardiac sarcoidosis population remaining robust in subgroup subanalysis. AV, atrioventricular; BNP, brain natriuretic peptide; CMR, cardiac magnetic resonance; FDG-PET, fluorodeoxyglucose positron emission tomography; HF, heart failure; LVEF, left ventricular ejection fraction; SCD, sudden cardiac death; SUVmax, maximum standardized uptake value; VT, ventricular tachycardia.