The cover image describes a novel and eco-friendly electrochemical strategy for the electrochemical activation of trifluoromethyl thianthrenium triflate (TT–CF₃⁺OTf⁻). The technique demonstrates successful trifluoromethylation of a diverse range of imidazole-fused heteroaromatic compounds without the requirement of external oxidants or catalysts, aligning with the principles of green chemistry. More details are discussed in the article by Yu et al. on page 1679—1685.

The acylhydrazonyl hybridization of aloe emodin and azole heterocycles afforded a new unique type of framework with multitargeting antibacterial potential. The highly active compound demonstrated strong antibacterial efficacy with broad antibacterial spectrum, low hemolysis and cytotoxicity, and favorable bioavailability. The active molecule could not only cause bacterial membrane depolarization and damage the cell membrane, resulting in nucleic acid leakage, but also intercalate into DNA to impede its replication and form DNA gyrase complex to disturb the function of DNA gyrase. More details are discussed in the article by Zhou et al. on page 1741—1758.

We present a novel and eco-friendly electrochemical strategy for the electrochemical activation of trifluoromethyl thianthrenium triflate to access trifluoromethylated imidazo-fused heteroaromatic compounds.

We reported Ru(II)-catalyzed C—H alkynylation of isoquinolones, quinazolones and phthalazinones with bromoalkynes. This protocol provides an approach towards access to various heterocyclic compounds in high yields (up to 95%).

A novel electrochemical multicomponent cascade reaction of indole-tethered alkenes with CF₃SO₂Na, n-Bu₄NI, and H₂O has been developed, which proceeds via oxidation of CF₃SO₂Na, coupling with alkene, spirocyclization, oxidation of sulfinate, iodide substitution, and water coupling enabling the rapid assembly of iodomethyl spiropyrrolidinyl-oxindoles in good yields.

By the effective chemical strategy of mono-/double-protonating organic cations, a novel molecular ferroelastic [Me₂NH(CH₂)₂NH₃](ReO₄)₂ was successfully prepared. Notably, it exhibits excellent mechanical flexibility and demonstrates the bright prospects in wearable and human-compatible electromechanical applications.

A novel biomimetic strategy is proposed to prepare the cell-tailored double-shelled CaCO₃/CaF₂ hollow nanospheres with hierarchically porous structure. The nanospheres exhibit excellent water dispersibility and favorable biocompatibility. Moreover, the nanospheres with special structure have a high drug loading capacity and a controlled drug release property, so it can be exploited as a sustained pH-sensitive drug delivery system.

The method for the homogeneous hydrogenation of nitroarenes to produce aromatic amines using low catalyst loading (1 mo%) of air-stable copper N-heterocyclic carbene complexes as the catalyst and ammonia borane as the source of hydrogen is reported.

Under controlled conditions, a chemodivergent synthesis of benzofurans and 2,3-dihydrobenzofurans was achieved through the tandem reaction of enaminones and salicylaldehydes, employing a reaction system with DBDMH and K₂CO₃ promotors. The key to success was identifying the reaction parameters, wherein the imine intermediate formed through transient halogenation coupling and substitution processes underwent either aldol condensation/annulation or imine hydrolysis/aldol condensation.

The three-component hybridization of aloe emodin and azole heterocycles with acylhydrazonyl group as linker afforded a new unique type of framework azolyl acylhydrazonyl aloe emodins. Their medicinal identification revealed that azole-hybridized acylhydrazonyl aloe emodins could act as the promising lead antibacterial agents.

The imide-functionalized polymers are very promising donor materials for non-fullerene OSCs. Aiming to promote future innovation in imide-functionalized polymers, this review summarized the synthetic routes of imide building units, and the structural evolution of imide-functionalized polymer donors by focusing on the effects of polymer structure on their physical, optoelectronic, and photovoltaic properties

Systems derived from synthetic helical molecules and SNPs exhibit notable chemical reactions including selective adsorption and molecular recognition, equilibrium shift, step kinetics with induction period, precipitation with flow and sweeping, and disaggregation and desorption by sonication.

The method for the homogeneous hydrogenation of nitroarenes to produce aromatic amines using low catalyst loading (1 mo%) of air-stable copper N-heterocyclic carbene complexes as the catalyst and ammonia borane as the source of hydrogen is reported. More details are discussed in the article by Han et al. on page 1721—1726.

Molecular ferroelastic materials have the natural properties of spontaneous strain switching and potential applications in intelligent actuator. Under the guidance of the single/double protonation strategy, we successfully obtained the molecular ferroelasticity [Me₂NH(CH₂)₂NH₃](ReO₄)₂ (Me₂NH(CH₂)₂NH₃ = N,N-dimethylethylenediamine). This work further enriches the family of ferroelastic molecules and demonstrates that single/double protonation is one of the effective molecular modification strategies for designing ferroelasticity. More details are discussed in the article by Fu et al. on page 1706—1712.