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    Annals of Neurology: Volume 97, Issue 4

    C1, i-vi, 609-806
    April 2025
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Free Access

Annals of Neurology: Volume 97, Number 4, April 2025

  • Page: C1
  • First Published: 08 March 2025

Issue Information

Free Access

Issue Information

  • Pages: i-vi
  • First Published: 08 March 2025

ANA podcasts & Webinars

ANA Investigates: Atrial Fibrillation after Stroke

Christoph Stretz MD,  Adeline L. Goss MD,  Michelle C. Johansen MD, PhD,  Luciano A. Sposato MD, MBA, 
  • Pages: 609-610
  • First Published: 14 February 2025

Research Article

Open Access

Congenital Titinopathy: Comprehensive Characterization of the Most Severe End of the Disease Spectrum

Sandra Coppens MD, PhD,  Nicolas Deconinck MD, PhD,  Patricia Sullivan BAdvSci(Hons), PhD,  Andrei Smolnikov BAdvSci(Hons), BA, MA(Res),  Joshua S. Clayton PhD,  Kaitlyn R. Griffin BSc, MNurs,  Kristi J. Jones MBBS, FRACP, PhD,  Catheline N. Vilain MD, PhD,  Hazim Kadhim MD, PhD, DCH, MB-ChB, Board (Neuropathology),  Samantha J. Bryen BSc(Hons), PhD,  Fathimath Faiz PhD,  Leigh B. Waddell BMedSc, PhD,  Frances J. Evesson PhD,  Madhura Bakshi MBBS, MD, DCh, FRACP,  Jason R. Pinner BA, MA, MBBS, FRACP,  Amanda Charlton MBChB, BMedSc, FRCPA,  Susan Brammah BSc, MApplSc,  Nicole S. Graf MBBS, FRCPA,  Michael Krivanek MBBS, FRCPA,  Chee Geap Tay MBBS, MPaeds,  Nicola C. Foulds BSc, MA, PhD, MBChB, FRCP,  Marjorie A. Illingworth MB BCH BAO(Hons), MRCPCH,  Neil H. Thomas MA, MB BChir, FRCP, FRCPCH, DCH,  Sian Ellard PhD, FRCPath,  Ingrid Mazanti MD,  Soo-Mi Park BSc, MBBS, PhD, FRCP,  Courtney E. French PhD,  Jennifer Brewster MB ChB, MRCOG,  Gusztav Belteki MD, PhD, FRCPCH,  Shazia Hoodbhoy BM BS, MRCPCH,  Kieren Allinson BSc (Hons), MBChB, FRCPath,  Deepa Krishnakumar MBBS, MRCPCH, DCH,  Gareth Baynam MBBS, PhD,  Bradley M. Wood MBBS, FRANZCR,  Michelle Ward BSc, PGDip,  Kayal Vijayakumar MBBS, MRCPCH,  Amber Syed BSc, MBBCh, MRCPCH,  Archana Murugan MB BS,  Anirban Majumdar BMBS, FRCPCH,  Ingrid J. Scurr BSc, MBBS, MRCPCH,  Miranda P. Splitt MBBS, MD, FRCP,  Corina Moldovan MD, MPH, FRCPath,  Deepthi C. de Silva MBChB, MRCP,  Kumudu Senanayake MBBS, MD (Histopath),  Thatjana Gardeitchik MD, PhD,  Yvonne Arens MD, PhD,  Sandra T. Cooper PhD,  Nigel G. Laing PhD,  F. Lucy Raymond MD, DPhil, FRCP, FRCPath,  Heinz Jungbluth MD, PhD,  Erik-Jan Kamsteeg PhD,  Adnan Manzur MB BS, FRCPCH,  Susan M. Corley LLB, LLM, BSc(Hons), PhD,  Gianina Ravenscroft PhD,  Marc R. Wilkins BSc(Hons), PhD, DSc,  Mark J. Cowley BSc(Bioinf), PhD,  Mark Pinese BSc(Hons), PhD,  Titin Research Consortium ,  Rahul Phadke MD, FRCPath,  Mark R. Davis PhD,  Francesco Muntoni MD,  Emily C. Oates BMedSc(Hons), MBBS(Hons), FRACP, PhD, 
  • Pages: 611-628
  • First Published: 24 January 2025

Loss of TDP-43 Splicing Repression Occurs in Myonuclei of Inclusion Body Myositis Patients

Chiseko Ikenaga MD, PhD,  Andrew B. Wilson PhD,  Katherine E. Irwin MS,  Aswathy Peethambaran Mallika PhD,  Collin Kilgore MS,  Irika R. Sinha MS,  Elizabeth H. Michelle MD,  Jonathan P. Ling PhD,  Philip C. Wong PhD,  Thomas E. Lloyd MD, PhD, 
  • Pages: 629-641
  • First Published: 06 January 2025
Open Access

Early-Life Adversity Predicts Markers of Aging-Related Neuroinflammation, Neurodegeneration, and Cognitive Impairment in Women

Lara Fleck MSc,  Claudia Buss PhD,  Martin Bauer MSc,  Maike Stein MD,  Ralf Mekle PhD,  Lena Kock MSc,  Heiko Klawitter MSc,  Malvika Godara PhD,  Judith Ramler MSc,  Sonja Entringer PhD,  Matthias Endres MD,  Christine Heim PhD, 
  • Pages: 642-656
  • First Published: 09 January 2025
Open Access

Inhibition of Bone Morphogenetic Protein Signaling Prevents Tau Pathology in iPSC Derived Neurons and PS19 Mice

Amira Affaneh PhD,  Anne K. Linden BS,  Elif Tunc-Ozcan PhD,  Yung-Hsu Tsai MSc,  Chian-Yu Peng PhD,  John A. Kessler MD, 
  • Pages: 657-672
  • First Published: 07 December 2024
Open Access

Prophylactic Fetal Creatine Supplementation Improves Post-Asphyxial EEG Recovery and Reduces Seizures in Fetal Sheep: Implications for Hypoxic–Ischemic Encephalopathy

Nhi T. Tran PhD,  Stacey J. Ellery PhD,  Sharmony B. Kelly PhD,  Juliane Sévigny BSc,  Madeleine Chatton BBSc,  Hui Lu BVSc,  Graeme R. Polglase PhD,  Rod J. Snow PhD,  David W. Walker PhD, DSc,  Robert Galinsky PhD, 
  • Pages: 673-687
  • First Published: 07 December 2024

Brief Communication

Prolonged Febrile Seizure and Long-Term Neurological Sequelae in Otherwise Healthy Children

Takenori Suga MD,  Takeshi Yoshida MD, PhD,  Atsushi Yokoyama MD, PhD,  Yotaro Hanami MD,  Kazushige Ashina MD,  Natsumi Nakamura MD,  Koji Kawakami MD, PhD,  Junko Takita MD, PhD,  Masato Takeuchi MD, MPH, PhD, 
  • Pages: 688-693
  • First Published: 27 January 2025

Neuro-Images

Infundibulum of an Aberrant Accessory MCA Mimics Aneurysm

Wai Ting Lui MD,  Tao Xiong MD,  Bo Yang MD,  Ning Ma MD, 
  • Pages: 694-695
  • First Published: 23 December 2024

Cinematic Rendering of Twig-Like Middle Cerebral Artery

Linggen Dong MD,  Ming Lv MD, 
  • Pages: 696-697
  • First Published: 21 December 2024

Research Article

Critical Care Decisions After Large Core Cerebral Infarctions: A Secondary Analysis From the SELECT2 Trial

Scott E. Kasner MD,  Michael T. Mullen MD,  Michael DeGeorgia MD,  Spiros Blackburn MD,  Donna K. George MD,  Monisha Kumar MD,  Steven Messe MD,  Michael G. Abraham MD,  Michael Chen MD,  Santiago Ortega-Gutierrez MD,  Clark W. Sitton MD,  Jan-Karl Burkhardt MD,  Muhammad Shazam Hussain MD,  Leonid Churilov PhD,  Sophia Sundararajan MD,  Yin C. Hu MD,  Nabeel A. Herial MD,  Pascal Jabbour MD,  Daniel Gibson MD,  Juan F. Arenillas MD, PhD,  Jenny P. Tsai MD,  Ronald F. Budzik MD,  William J. Hicks MD,  Osman Kozak MD,  Bernard Yan MBBS,  Dennis J. Cordato PhD,  Nathan W. Manning MBBS,  Mark W. Parsons PhD,  Ricardo A. Hanel MD,  Amin N. Aghaebrahim MD,  Teddy Y. Wu PhD,  Pere Cardona Portela MD,  Natalia Pérez de la Ossa MD, PhD,  Joanna D. Schaafsma MD,  Jordi Blasco MD, PhD,  Navdeep Sangha MD,  Steven Warach MD,  Chirag D. Gandhi MD,  Timothy J. Kleinig PhD,  Daniel Sahlein MD,  Edgar A. Samaniego MD,  Laith Maali MD,  Mohammad A. Abdulrazzak MD,  Krishna Amuluru MD,  Deep K. Pujara MBBS,  Faris Shaker MBChB,  Hannah Johns PhD,  Rami Moussa BS,  Faisal Al-Shaibi MD,  Kelsey R. Duncan MD,  Stavropoula Tjoumakaris MD,  Amanda Opaskar MD,  Wei Xiong MD,  Abhishek Ray MD,  Sepideh Amin-Hanjani MD,  Thanh N. Nguyen MD,  Johanna T. Fifi MD,  Stephen Davis MD,  Lawrence Wechsler MD,  Anthony Furlan MD,  Cathy Sila MD,  Nicholas Bambakidis MD,  Michael D. Hill MD,  Vitor Mendes Pereira MD,  Maarten G. Lansberg MD,  James C. Grotta MD,  Marc Ribo MD,  Greg W. Albers MD,  Bruce C. Campbell PhD,  Ameer E. Hassan DO,  Amrou Sarraj MD,  for the SELECT2 Investigators , 
  • Pages: 698-708
  • First Published: 09 December 2024

Association that Neuroimaging and Clinical Measures Have with Change in Arm Impairment in a Phase 3 Stroke Recovery Trial

Anne Schwarz PhD,  Marc Feldman BS,  Vu Le MS,  Jesse Dawson MD,  Charles Y. Liu MD, PhD,  Gerard E. Francisco MD,  Steven L. Wolf PhD, PT,  Anand Dixit MD,  Jen Alexander MSc,  Rushna Ali MD,  Benjamin L. Brown MD,  Wuwei Feng MD,  Louis DeMark DPT,  Leigh R. Hochberg MD, PhD,  Steven A. Kautz PhD,  Arshad Majid MD,  Michael W. O'Dell MD,  Jessica Redgrave MD,  Duncan L. Turner PhD, BSc,  Teresa J. Kimberley PT, PhD,  Steven C. Cramer MD, 
  • Pages: 709-719
  • First Published: 16 December 2024

Identifying Individuals in the Prodromal Phase of Parkinson's Disease: A Prospective Cohort Study

Mario H. Flores-Torres MD, PhD,  Katherine C. Hughes PhD,  Marianna Cortese MD, PhD,  Albert Y. Hung MD, PhD,  Brian C. Healy PhD,  Michael A. Schwarzschild MD, PhD,  Kjetil Bjornevik MD, PhD,  Alberto Ascherio MD, ScD, 
  • Pages: 720-729
  • First Published: 19 December 2024
Open Access

Staged Screening Identifies People with Biomarkers Related to Neuronal Alpha-Synuclein Disease

Ethan G. Brown MD,  Lana M. Chahine MD,  Andrew Siderowf MD,  Caroline Gochanour MS,  Ryan Kurth MS,  Micah J. Marshall MS,  Chelsea Caspell-Garcia MS,  Michael C. Brumm MS,  Craig E. Stanley Jr PhD,  Monica Korell MPH,  Bridget McMahon BS,  Maggie Kuhl BA,  Kimberly Fabrizio BA,  Laura Heathers BA,  Luis Concha-Marambio PhD,  Claudio Soto PhD,  Sohini Chowdhury MA,  Christopher S. Coffey PhD,  Tatiana M. Foroud PhD,  Tanya Simuni MD,  Kenneth Marek MD,  Caroline M. Tanner PhD,  The Parkinson Progression Marker Initiative , 
  • Pages: 730-740
  • First Published: 24 December 2024
Open Access

Propranolol Reduces Parkinson's Tremor and Inhibits Tremor-Related Activity in the Motor Cortex: A Placebo-Controlled Crossover Trial

Anouk van der Heide PhD,  Maaike Wessel MSc,  Danae Papadopetraki MSc,  Dirk E.M. Geurts MD, PhD,  Teije H. van Prooije MD,  Frank Gommans MD, PhD,  Bastiaan R. Bloem MD, PhD,  Michiel F. Dirkx MD, PhD,  Rick C. Helmich MD, PhD, 
  • Pages: 741-752
  • First Published: 21 December 2024
Open Access

The Utility of Long-Read Sequencing in Diagnosing Early Onset Parkinson's Disease

Kensuke Daida MD, PhD,  Hiroyo Yoshino PhD,  Laksh Malik MFS,  Breeana Baker BSc,  Mayu Ishiguro MD, PhD,  Rylee Genner MS,  Kimberly Paquette BA,  Yuanzhe Li MD, PhD,  Kenya Nishioka MD, PhD,  Satoshi Masuzugawa MD,  Makito Hirano MD, PhD,  Kenta Takahashi MD, PhD,  Mikhail Kolmogorov PhD,  Kimberley J. Billingsley PhD,  Manabu Funayama PhD,  Cornelis Blauwendraat PhD,  Nobutaka Hattori MD, PhD, 
  • Pages: 753-765
  • First Published: 19 December 2024

Increased White Matter Aerobic Glycolysis in Multiple Sclerosis

Matthew R Brier MD, PhD,  Bradley Judge BS,  Chunwei Ying PhD,  Amber Salter PhD,  Hongyu An PhD,  Aakash Patel MS,  Qing Wang PhD,  Yong Wang PhD,  Anne H Cross MD,  Robert T Naismith MD,  Tammie LS Benzinger MD, PhD,  Manu S Goyal MD, 
  • Pages: 766-778
  • First Published: 23 December 2024
Open Access

Atlas of Cerebrospinal Fluid Immune Cells Across Neurological Diseases

Michael Heming MD,  Anna-Lena Börsch MSc,  Simone Melnik MSc,  Noemi Gmahl MD,  Louisa Müller-Miny MD,  Christine Dambietz MD,  Lukas Fisch MSc,  Timm Kühnel MSc,  Tobias J. Brix PhD,  Alice Janssen MSc,  Eva Schumann MSc,  Catharina C. Gross PhD,  Julian Varghese MD,  Tim Hahn PhD,  Heinz Wiendl MD,  Gerd Meyer zu Hörste MD, 
  • Pages: 779-790
  • First Published: 12 December 2024
Open Access

Automated Neuroprognostication Via Machine Learning in Neonates with Hypoxic-Ischemic Encephalopathy

John D. Lewis PhD,  Atiyeh A. Miran MD,  Michelle Stoopler MD,  Helen M. Branson MD,  Ashley Danguecan PhD,  Krishna Raghu MD,  Linh G. Ly MD,  Mehmet N. Cizmeci MD,  Brian T. Kalish MD, 
  • Pages: 791-802
  • First Published: 10 December 2024

Neuro-Images

Spontaneous Pneumocephalus Due to Skull Base Defect and Spinal Cerebrospinal Fluid-Venous Fistula

Simon A. Menaker MD,  Gregory P. Lekovic MD, PhD,  Wouter I. Schievink MD, 
  • Pages: 803-804
  • First Published: 09 December 2024

Letter/Reply

Precision Medicine and Stroke Rehabilitation in Atrial Fibrillation: Exploring the Multidimensional Impacts of Vessel Occlusion, Age, and Treatment

Xueneng Yang MSc,  Ruijuan Li MSc,  Jun Shu MD, 
  • Page: 805
  • First Published: 14 February 2025

Reply to “Precision Medicine and Stroke Rehabilitation in Atrial Fibrillation: Exploring the Multidimensional Impacts of Vessel Occlusion, Age, and Treatment”

Alexander P. Benz,  David Seiffge, 
  • Page: 806
  • First Published: 14 February 2025