• Issue

    Journal of Pharmaceutical Sciences: Volume 100, Issue 9

    3541-4043
    September 2011
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Commentary

Free Access

Professor Akira Tsuji: Scientist, Educator, and Leader

Tetsuya Terasaki,  Yuichi Sugiyama,  Leslie Z. Benet, 
  • Pages: 3541-3546
  • First Published: 31 May 2011

Review

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Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: Methodology, advantages, strategy, and prospects

Sumio Ohtsuki,  Yasuo Uchida,  Yoshiyuki Kubo,  Tetsuya Terasaki, 
  • Pages: 3547-3559
  • First Published: 10 May 2011
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Molecular basis of chronopharmaceutics

Shigehiro Ohdo,  Satoru Koyanagi,  Naoya Matsunaga,  Ahmed Hamdan, 
  • Pages: 3560-3576
  • First Published: 07 June 2011
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Preclinical prediction of human brain target site concentrations: Considerations in extrapolating to the clinical setting

Joost Westerhout,  Meindert Danhof,  Elizabeth C. M. De Lange, 
  • Pages: 3577-3593
  • First Published: 04 May 2011
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Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders

Takafumi Hara,  Akira Hirasawa,  Atsuhiko Ichimura,  Ikuo Kimura,  Gozoh Tsujimoto, 
  • Pages: 3594-3601
  • First Published: 25 May 2011
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Ubiquitin-mediated proteasomal degradation of ABC transporters: a new aspect of genetic polymorphisms and clinical impacts

Hiroshi Nakagawa,  Yu Toyoda,  Kanako Wakabayashi-Nakao,  Hideaki Tamaki,  Masako Osumi,  Toshihisa Ishikawa, 
  • Pages: 3602-3619
  • First Published: 12 May 2011
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Pdz adaptors: Their regulation of epithelial transporters and involvement in human diseases

Tomoko Sugiura,  Takuya Shimizu,  Ai Kijima,  Sosuke Minakata,  Yukio Kato, 
  • Pages: 3620-3635
  • First Published: 27 April 2011
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Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors

Latoya Griffin,  Pieter Annaert,  Kim L.R. Brouwer, 
  • Pages: 3636-3654
  • First Published: 22 June 2011

Reviews

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First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics

Baojian Wu,  Kaustubh Kulkarni,  Sumit Basu,  Shuxing Zhang,  Ming Hu, 
  • Pages: 3655-3681
  • First Published: 11 April 2011

Review

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Update on the pharmacokinetics and redox properties of protein-bound uremic toxins

Hiroshi Watanabe,  Yohei Miyamoto,  Masaki Otagiri,  Toru Maruyama, 
  • Pages: 3682-3695
  • First Published: 29 April 2011
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Transcriptional regulation of organic anion transporting polypeptide SLCO4C1 as a new therapeutic modality to prevent chronic kidney disease

Takehiro Suzuki,  Takafumi Toyohara,  Yasutoshi Akiyama,  Yoichi Takeuchi,  Eikan Mishima,  Chitose Suzuki,  Sadayoshi Ito,  Tomoyoshi Soga,  Takaaki Abe, 
  • Pages: 3696-3707
  • First Published: 07 June 2011
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Mother-to-fetus transfer of antiviral drugs and the involvement of transporters at the placental barrier

Masatoshi Tomi,  Tomohiro Nishimura,  Emi Nakashima, 
  • Pages: 3708-3718
  • First Published: 29 May 2011
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Sodium-dependent phosphate cotransporters: Lessons from gene knockout and mutation studies

Ken-Ichi Miyamoto,  Sakiko Haito-Sugino,  Shoji Kuwahara,  Akiko Ohi,  Kengo Nomura,  Mikiko Ito,  Masashi Kuwahata,  Shinsuke Kido,  Sawako Tatsumi,  Ichiro Kaneko,  Hiroko Segawa, 
  • Pages: 3719-3730
  • First Published: 12 May 2011
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Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy

Takeo Nakanishi,  Ikumi Tamai, 
  • Pages: 3731-3750
  • First Published: 31 May 2011

Biotechnology

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GM1 expression in caco-2 cells: Characterisation of a fundamental passage-dependent transformation of a cell line

Kristina A. Jahn,  Joanna M. Biazik,  Filip Braet, 
  • Pages: 3751-3762
  • First Published: 22 December 2010

Drug Discovery Interface

Open Access

Structural features determining the intestinal epithelial permeability and efflux of novel HIV-1 protease inhibitors

Lucia Lazorova,  Ina Hubatsch,  Jenny K. Ekegren,  Johan Gising,  Daisuke Nakai,  Noha M. Zaki,  Christel A. S. Bergström,  Ulf Norinder,  Mats Larhed,  Per Artursson, 
  • Pages: 3763-3772
  • First Published: 13 April 2011

Pharmaceutics, Preformulation and Drug Delivery

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6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs

Na-young Lee,  Yoshimichi Sai,  Emi Nakashima,  Sumio Ohtsuki,  Young-sook Kang, 
  • Pages: 3773-3782
  • First Published: 17 May 2011
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Development of polyethylene glycol-conjugated alendronate, a novel nitrogen-containing bisphosphonate derivative: Evaluation of absorption, safety, and effects after intrapulmonary administration in rats

Hidemasa Katsumi,  Miki Takashima,  Jun-Ichi Sano,  Kazushi Nishiyama,  Noriko Kitamura,  Toshiyasu Sakane,  Toru Hibi,  Akira Yamamoto, 
  • Pages: 3783-3792
  • First Published: 12 May 2011
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Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability

Satomi Onoue,  Atsushi Uchida,  Haruki Takahashi,  Yoshiki Seto,  Yohei Kawabata,  Kazunori Ogawa,  Kayo Yuminoki,  Naofumi Hashimoto,  Shizuo Yamada, 
  • Pages: 3793-3801
  • First Published: 24 April 2011
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Synthesis and in vitro characterization of drug conjugates of l-carnitine as potential prodrugs that target human Octn2

Lei Diao,  James E. Polli, 
  • Pages: 3802-3816
  • First Published: 31 March 2011
Free Access

Interactions between organic anions on multiple transporters in Caco-2 cells

Anne Sophie Grandvuinet,  Bente Steffansen, 
  • Pages: 3817-3830
  • First Published: 23 May 2011

Pharmacokinetics, Pharmacodynamics and Drug Metabolism

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Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics†

Maribel Reyes,  Leslie Z. Benet, 
  • Pages: 3831-3842
  • First Published: 26 May 2011
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Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein

Yoshiyuki Shirasaka,  Kensuke Suzuki,  Takeo Nakanishi,  Ikumi Tamai, 
  • Pages: 3843-3853
  • First Published: 24 April 2011
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Effect of milk on the pharmacokinetics of oseltamivir in healthy volunteers

Kaori Morimoto,  Kozue Kishimura,  Takaaki Nagami,  Nao Kodama,  Yoichiro Ogama,  Midori Yokoyama,  Shinya Toda,  Takeshi Chiyoda,  Rieko Shimada,  Akihiro Inano,  Takashi Kano,  Ikumi Tamai,  Takuo Ogihara, 
  • Pages: 3854-3861
  • First Published: 23 May 2011
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Cassette dosing for pharmacokinetic screening in drug discovery: Comparison of clearance, volume of distribution, half-life, mean residence time, and oral bioavailability obtained by cassette and discrete dosing in rats†

Rakesh Nagilla,  Melanie Nord,  Jeff J. Mcatee,  Larry J. Jolivette, 
  • Pages: 3862-3874
  • First Published: 01 March 2011
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Interindividual differences in placental expression of the SLC22A2 (OCT2) gene: Relationship to epigenetic variations in the 5′-upstream regulatory region†

Jumpei Saito,  Takeshi Hirota,  Naomi Kikunaga,  Kenji Otsubo,  Ichiro Ieiri, 
  • Pages: 3875-3883
  • First Published: 26 April 2011
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A randomized, quadruple crossover single-blind study on immediate action of chewed and unchewed low-dose acetylsalicylic acid tablets in healthy volunteers

Yoshimichi Sai,  Akiyo Kusaka,  Kaori Imanishi,  Manami Matsumoto,  Rie Takahashi,  Natsumi Sugimoto,  Junko Sugama,  Takako Anada,  Hidesaku Asakura,  Ken-Ichi Miyamoto, 
  • Pages: 3884-3891
  • First Published: 04 May 2011
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Inner blood–retinal barrier mediates l-isomer-predominant transport of serine

Masanori Tachikawa,  Masashi Okamoto,  Shirou Hirose,  Daisuke Yoneyama,  Shin-ichi Akanuma,  Tetsuya Terasaki,  Ken-ichi Hosoya, 
  • Pages: 3892-3903
  • First Published: 17 May 2011
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Comparison of drug permeabilities across the blood–retinal barrier, blood–aqueous humor barrier, and blood–brain barrier

Ryotaro Toda,  Kouichi Kawazu,  Masanobu Oyabu,  Tatsuya Miyazaki,  Yoshiaki Kiuchi, 
  • Pages: 3904-3911
  • First Published: 02 June 2011
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Diphenhydramine active uptake at the blood–brain barrier and its interaction with oxycodone in vitro and in vivo

Muhammad Waqas Sadiq,  Annika Borgs,  Takashi Okura,  Keita Shimomura,  Sayaka Kato,  Yoshiharu Deguchi,  Britt Jansson,  Sven Björkman,  Tetsuya Terasaki,  Margareta Hammarlund-udenaes, 
  • Pages: 3912-3923
  • First Published: 06 April 2011
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Functional characterization of rat plasma membrane monoamine transporter in the blood–brain and blood–cerebrospinal fluid barriers

Takashi Okura,  Sayaka Kato,  Yusuke Takano,  Takenori Sato,  Atsushi Yamashita,  Riyo Morimoto,  Sumio Ohtsuki,  Tetsuya Terasaki,  Yoshiharu Deguchi, 
  • Pages: 3924-3938
  • First Published: 02 May 2011
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Quantitative membrane protein expression at the blood–brain barrier of adult and younger cynomolgus monkeys

Katsuaki Ito,  Yasuo Uchida,  Sumio Ohtsuki,  Sanshiro Aizawa,  Hirotaka Kawakami,  Yuki Katsukura,  Junichi Kamiie,  Tetsuya Terasaki, 
  • Pages: 3939-3950
  • First Published: 19 January 2011
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Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression

Thomas Budde,  Jeanette Haney,  Sandra Bien,  Matthias Schwebe,  Alexander Riad,  Carsten Tschöpe,  Alexander Staudt,  Gabriele Jedlitschky,  Stephan B. Felix,  Heyo K. Kroemer,  Markus Grube, 
  • Pages: 3951-3958
  • First Published: 17 May 2011
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Enhancement of zidovudine transfer to molt-4 cells, a human t-cell model, by dehydroepiandrosterone sulfate

Tomohiro Nishimura,  Jun Tanaka,  Masatoshi Tomi,  Yoshiaki Seki,  Noriko Kose,  Yoshimichi Sai,  Emi Nakashima, 
  • Pages: 3959-3967
  • First Published: 13 May 2011
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Quantitative analysis of cysteine-34 on the anitioxidative properties of human serum albumin in hemodialysis patients

Makoto Anraku,  Koji Takeuchi,  Hiroshi Watanabe,  Daisuke Kadowaki,  Kenichiro Kitamura,  Kimio Tomita,  Akihiko Kuniyasu,  Ayaka Suenaga,  Toru Maruyama,  Masaki Otagiri, 
  • Pages: 3968-3976
  • First Published: 07 April 2011
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Accumulation of BNP7787 in human renal proximal tubule cells

F. H. Hausheer,  D. Ding,  D. Shanmugarajah,  B. D. Leverett,  Q. Huang,  X. Chen,  H. Kochat,  P. Y. Ayala,  P. N. Petluru,  A. R. Parker, 
  • Pages: 3977-3984
  • First Published: 22 February 2011
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Evaluation of transport mechanism of prodrugs and parent drugs formed by intracellular metabolism in Caco-2 cells with modified carboxylesterase activity: Temocapril as a model case

Kayoko Ohura,  Takaaki Nozawa,  Koichi Murakami,  Teruko Imai, 
  • Pages: 3985-3994
  • First Published: 26 May 2011
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The use of 13C–erythromycin as an in vivo probe to evaluate CYP3A-mediated drug interactions in rats

Erika Sugiyama,  Atsuko Kikuchi,  Makoto Inada,  Hitoshi Sato, 
  • Pages: 3995-4005
  • First Published: 26 May 2011
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Characterization of human OCT1-mediated transport of DAPI as a fluorescent probe substrate

Tomoya Yasujima,  Kinya Ohta,  Katsuhisa Inoue,  Hiroaki Yuasa, 
  • Pages: 4006-4012
  • First Published: 24 March 2011
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Establishment of In Vitro P-Glycoprotein inhibition assay and its exclusion criteria to assess the risk of drug–drug interaction at the drug discovery stage

Hiroshi Sugimoto,  Shin-ichi Matsumoto,  Miho Tachibana,  Shin-ichi Niwa,  Hideki Hirabayashi,  Nobuyuki Amano,  Toshiya Moriwaki, 
  • Pages: 4013-4023
  • First Published: 15 June 2011
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Comprehensive quantitative and qualitative liquid chromatography–radioisotope–mass spectrometry analysis for safety testing of tolbutamide metabolites without standard samples

Zenzaburo Tozuka,  Shinsuke Aoyama,  Kohei Nozawa,  Shoji Akita,  Toshinari Oh-Hara,  Yasuhisa Adachi,  Shin-Ichi Ninomiya, 
  • Pages: 4024-4036
  • First Published: 02 June 2011
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Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and Udp-glucuronosyltransferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometry with nano-liquid chromatography

Atsushi Sakamoto,  Takehisa Matsumaru,  Naoki Ishiguro,  Olaf Schaefer,  Sumio Ohtsuki,  Tae Inoue,  Hirotaka Kawakami,  Tetsuya Terasaki, 
  • Pages: 4037-4043
  • First Published: 04 May 2011