• Issue

    Allergy: Volume 74, Issue 11

    2045-2282
    November 2019

ISSUE INFORMATION

Free Access

Issue Information - Cover and Editorial Board

  • Page: 2045
  • First Published: 28 October 2019
Free Access

Issue Information - TOC

  • Pages: 2047-2048
  • First Published: 28 October 2019

IN THIS ISSUE

In this Issue: Graphical Abstracts

  • Pages: 2049-2051
  • First Published: 28 October 2019

REVIEW ARTICLES

Free Access

2019 ARIA Care pathways for allergen immunotherapy

Jean Bousquet Oliver Pfaar Alkis Togias Holger J. Schünemann Ignacio Ansotegui Nikolaos G. Papadopoulos Ioanna Tsiligianni Ioana Agache Josep M. Anto Claus Bachert Anna Bedbrook Karl-Christian Bergmann Sinthia Bosnic-Anticevich Isabelle Bosse Jan Brozek Moises A. Calderon Giorgio W. Canonica Luigi Caraballo Victoria Cardona Thomas Casale Lorenzo Cecchi Derek Chu Elisio Costa Alvaro A. Cruz Wienczyslawa Czarlewski Stephen R. Durham George Du Toit Mark Dykewicz Motohiro Ebisawa Jean Luc Fauquert Montserrat Fernandez-Rivas Wytske J. Fokkens João Fonseca Jean-François Fontaine Roy Gerth van Wijk Tari Haahtela Susanne Halken Peter W. Hellings Despo Ierodiakonou Tomohisa Iinuma Juan Carlos Ivancevich Lars Jacobsen Marek Jutel Igor Kaidashev Musa Khaitov Omer Kalayci Jörg Kleine Tebbe Ludger Klimek Marek L. Kowalski Piotr Kuna Violeta Kvedariene Stefania La Grutta Désirée Larenas-Linemann Susanne Lau Daniel Laune Lan Le Karin Lodrup Carlsen Olga Lourenço Hans-Jørgen Malling Gert Marien Enrica Menditto Gregoire Mercier Joaquim Mullol Antonella Muraro Robyn O’Hehir Yoshitaka Okamoto Giovanni B. Pajno Hae-Sim Park Petr Panzner Giovanni Passalacqua Nhan Pham-Thi Graham Roberts Ruby Pawankar Christine Rolland Nelson Rosario Dermot Ryan Bolesław Samolinski Mario Sanchez-Borges Glenis Scadding Mohamed H. Shamji Aziz Sheikh Gunter J. Sturm Ana Todo Bom Sanna Toppila-Salmi Maryline Valentin-Rostan Arunas Valiulis Erkka Valovirta Maria-Teresa Ventura Ulrich Wahn Samantha Walker Dana Wallace Susan Waserman Arzu Yorgancioglu Torsten Zuberbier the ARIA Working Group
  • Pages: 2087-2102
  • First Published: 07 April 2019

ORIGINAL ARTICLES

Basic and Translational Allergy Immunology

miR-10a-5p is increased in atopic dermatitis and has capacity to inhibit keratinocyte proliferation

  • Pages: 2146-2156
  • First Published: 02 May 2019
miR-10a-5p is increased in atopic dermatitis and has capacity to inhibit keratinocyte proliferation

The expression of miR-10a-5p is increased in the skin of patients with atopic dermatitis, in proliferating keratinocytes, and in response to growth factor heparin-binding EGF-like growth factor. miR-10a-5p has capacity to inhibit keratinocytes proliferation, the expression of mitogen-activated kinase 3 kinase 7 and hyaluronan synthase 3, pro-inflammatory chemokines IL-8 and CCL5, and numerous genes affecting cell cycle progression. miR-10a-5p inhibits proliferation and to less extent the inflammation and cell adhesion of keratinocytes and thereby may affect the development and severity of atopic dermatitis.

Open Access

Modulation of CRTh2 expression on allergen-specific T cells following peptide immunotherapy

  • Pages: 2157-2166
  • First Published: 11 May 2019
Modulation of CRTh2 expression on allergen-specific T cells following peptide immunotherapy

Peptide immunotherapy with Cat-PAD reduces the surface expression of Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) on Fel d 1-specific T cells. Neither the frequency, nor memory phenotype of Fel d 1-specific T cells in the blood were affected by peptide immunotherapy for cat allergy. Reduced expression of CRTh2 may modulate recruitment to sites of allergen exposure.

Interaction of Alt a 1 with SLC22A17 in the airway mucosa

  • Pages: 2167-2180
  • First Published: 16 May 2019
Interaction of Alt a 1 with SLC22A17 in the airway mucosa

Alt a 1 is released from Alternaria alternata spores in complex with its native ligand, being recognized by the Solute carrier family 22 member 17 receptor. Production of cytokines IL25 and IL33 occurs only in the presence of the ligand, being abolished with specific antibodies against Solute carrier family 22 member 17. Alt a 1 shows structural relationship with human siderocalin mimicking its airway entry route.

Asthma and Lower Airway Disease

Open Access

Oral corticosteroid use, morbidity and mortality in asthma: A nationwide prospective cohort study in Sweden

  • Pages: 2181-2190
  • First Published: 16 May 2019

Oral corticosteroid use, morbidity and mortality in asthma: A nationwide prospective cohort study in Sweden

Annually, almost one in seven asthma patients used oral corticosteroids, which was stable over the 10-year study period. Oral corticosteroids are still a substantial part of current asthma management for many patients and are associated with severe side effects and mortality risk. There is a need for other treatments for severe asthma patients who are using regular oral corticosteroids.

Rhinitis, Sinusitis, and Upper Airway Disease

Determination of the minimally important difference in a nasal symptom score in house dust mite allergy

  • Pages: 2191-2198
  • First Published: 24 May 2019
Determination of the minimally important difference in a nasal symptom score in house dust mite allergy

In patients with house dust mite allergic rhinoconjunctivitis, the minimal important difference for improvement in a four-item nasal symptom score was at least 0.9 units. This value was estimated in children (n=187), adolescents (n=125), and adults (n=197) by both regression analyses using anchors and distribution-based analyses using the standard deviation (SD). The anchors in the regression analyses were either a 15-point global rating of change scale or the age-specific Rhinoconjunctivitis Quality of Life Questionnaires.

Food Allergy and Gastrointestinal Disease

Clinical factors associated with peanut allergy in a high-risk infant cohort

  • Pages: 2199-2211
  • First Published: 23 May 2019
Clinical factors associated with peanut allergy in a high-risk infant cohort

In high-risk infants (eg, moderate to severe eczema and egg/milk sensitizationor likely egg/milk allergy), parameters associated with the development of peanut allergy were identified. Multivariate models identified younger age at initial assessment, higher peanut IgE and Ara h2 IgE levels, and lack of breastfeeding (BF) as significant associated factors. Models were constructed to predict risk of peanut allergy based on these variables.

Epidemiology and Genetics

Dog ownership at three months of age is associated with protection against food allergy

  • Pages: 2212-2219
  • First Published: 11 May 2019

Dog ownership at three months of age is associated with protection against food allergy

Dog ownership was associated with a significant reduction in the development of food allergy amongst a prospective birth cohort. Physiological plausibility was enhanced by finding dose-response effects and inverse associations with food and house dust mite sensitization.The inverse relationship with food sensitization was appearing by three months, suggesting that immune modulation may commence from birth or prenatally.

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NEWS & VIEWS

Algorithms in Allergy and Clinical Immunology