M2 macrophages correlated with symptom severity and promote type 2 inflammation in allergic rhinitis
Hongfei Lou
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorYanran Huang
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorHui Chen
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorYang Wang
Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China
Search for more papers by this authorCorresponding Author
Luo Zhang
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China
Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Correspondence
Chengshuo Wang, Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, China.
Email: [email protected]
and
Luo Zhang, Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing 100005, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Chengshuo Wang
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Correspondence
Chengshuo Wang, Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, China.
Email: [email protected]
and
Luo Zhang, Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing 100005, China.
Email: [email protected]
Search for more papers by this authorHongfei Lou
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorYanran Huang
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorHui Chen
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorYang Wang
Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China
Search for more papers by this authorCorresponding Author
Luo Zhang
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China
Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Correspondence
Chengshuo Wang, Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, China.
Email: [email protected]
and
Luo Zhang, Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing 100005, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Chengshuo Wang
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Correspondence
Chengshuo Wang, Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, China.
Email: [email protected]
and
Luo Zhang, Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing 100005, China.
Email: [email protected]
Search for more papers by this author
Supporting Information
| Filename | Description |
|---|---|
| all13852-sup-0001-FigS1.tiffTIFF image, 8.8 MB | |
| all13852-sup-0002-FigS2.tiffTIFF image, 4.2 MB | |
| all13852-sup-0003-FigS3.tiffTIFF image, 4.7 MB | |
| all13852-sup-0004-FigS4.tiffTIFF image, 5.1 MB | |
| all13852-sup-0005-Supinfo.docxapplication/docx, 1 MB |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
- 1Jiang Z, Zhu L. Update on the role of alternatively activated macrophages in asthma. J Asthma Allergy. 2016; 9: 101-107.
- 2Tarique AA, Logan J, Thomas E, Holt PG, Sly PD, Fantino E. Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages. Am J Respir Cell Mol Biol. 2015; 53: 676-688.
- 3Peterson S, Poposki JA, Nagarkar DR, et al. Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2012; 129(1): 119-127.
- 4Vijayanand P, Durkin K, Hartmann G, et al. Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients. J Immunol. 2010; 184: 4568-4574.
- 5Wang Y, Zhu J, Zhang L, et al. Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6/transcription factor EC/IL-4 receptor alpha positive feedback loop in M2 macrophages. J Allergy Clin Immunol. 2017; 140: 1550-1561.
- 6Melgert BN, ten Hacken NH, Rutgers B, Timens W, Postma DS, Hylkema MN. More alternative activation of macrophages in lungs of asthmatic patients. J Allergy Clin Immunol. 2011; 127: 831-833.
- 7Dasgupta P, Keegan AD. Contribution of alternatively activated macrophages to allergic lung inflammation: a tale of mice and men. J Innate Immun. 2012; 4: 478-488.
- 8Lee CG, Hartl D, Lee GR, et al. Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med. 2009; 206: 1149-1166.
- 9Staples KJ, Hinks TS, Ward JA, Gunn V, Smith C, Djukanovic R. Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17. J Allergy Clin Immunol. 2012; 130: 1404-1412.
Citing Literature
