• Issue

    Medicinal Research Reviews: Volume 44, Issue 6

    i-ii, 2363-2848
    November 2024
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COVER IMAGE

Free Access

Front Cover Image, Volume 44, Issue 6

Yunxiao Zhong,  Xinya Zhang,  Ruibing Feng,  Yu Fan,  Zhang Zhang,  Qing-Wen Zhang,  Jian-Bo Wan,  Yitao Wang,  Hua Yu,  Guodong Li, 
  • Page: i
  • First Published: 03 October 2024
Front Cover Image, Volume 44, Issue 6 Volume 44 Issue 6, 2024

The cover image is based on the article OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage by Yunxiao Zhong et al., https://doi.org/10.1002/med.22068.

Free Access

Inside Front Cover Image, Volume 44, Issue 6

Vijay K. Boda,  Nelufar Yasmen,  Jianxiong Jiang,  Wei Li, 
  • Page: ii
  • First Published: 03 October 2024
Inside Front Cover Image, Volume 44, Issue 6 Volume 44 Issue 6, 2024

The cover image is based on the article Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel by Vijay K. Boda et al., https://doi.org/10.1002/med.22048.

ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 2363-2366
  • First Published: 03 October 2024

REVIEW ARTICLE

Open Access

Innovative pathological network-based multitarget approaches for Alzheimer's disease treatment

Paloma Mayo,  Jorge Pascual,  Enrique Crisman,  Cristina Domínguez,  Manuela G. López,  Rafael León, 
  • Pages: 2367-2419
  • First Published: 28 April 2024

Engineering peptide drug therapeutics through chemical conjugation and implication in clinics

Syed Faheem Askari Rizvi,  Haixia Zhang,  Quan Fang, 
  • Pages: 2420-2471
  • First Published: 05 May 2024
Open Access

Targeting lysosomal quality control as a therapeutic strategy against aging and diseases

Yuchen He,  Yishu Fan,  Xenab Ahmadpoor,  Yumin Wang,  Zhong Alan Li,  Weihong Zhu,  Hang Lin, 
  • Pages: 2472-2509
  • First Published: 06 May 2024

Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel

Vijay K. Boda,  Nelufar Yasmen,  Jianxiong Jiang,  Wei Li, 
  • Pages: 2510-2544
  • First Published: 07 May 2024
Open Access

Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach

Marie Emilie Hovah,  Ulrike Holzgrabe, 
  • Pages: 2545-2599
  • First Published: 15 May 2024

MINI REVIEW

Rethinking therapeutic strategies of dual-target drugs: An update on pharmacological small-molecule compounds in cancer

Yiren Yang,  Yi Mou,  Lin-Xi Wan,  Shiou Zhu,  Guan Wang,  Huiyuan Gao,  Bo Liu, 
  • Pages: 2600-2623
  • First Published: 20 May 2024

Counter-intuitive discovery in the formulation of poorly water-soluble drugs: Amorphous small-molecule gels

Yecheng Shu,  Peixu Zhao,  Xin Li,  Xianbao Shi,  Qiang Fu, 
  • Pages: 2624-2639
  • First Published: 28 May 2024

REVIEW ARTICLE

Advances in drug design and therapeutic potential of selective or multitarget 5-HT1A receptor ligands

Gianfabio Giorgioni,  Alessandro Bonifazi,  Luca Botticelli,  Carlo Cifani,  Federica Matteucci,  Emanuela Micioni Di Bonaventura,  Maria Vittoria Micioni Di Bonaventura,  Mario Giannella,  Alessandro Piergentili,  Alessia Piergentili,  Wilma Quaglia,  Fabio Del Bello, 
  • Pages: 2640-2706
  • First Published: 29 May 2024
Open Access

The antisickling agent, 5-hydroxymethyl-2-furfural: Other potential pharmacological applications

Piyusha P. Pagare,  Mina McGinn,  Mohini S. Ghatge,  Vibha Shekhar,  Rana T. Alhashimi,  B. Daniel Pierce,  Osheiza Abdulmalik,  Yan Zhang,  Martin K. Safo, 
  • Pages: 2707-2729
  • First Published: 06 June 2024
Open Access

Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future

Victoria Judith Morel,  Jochen Rössler,  Michele Bernasconi, 
  • Pages: 2730-2773
  • First Published: 17 June 2024
Open Access

Poly (adenosine diphosphate-ribose) polymerase inhibitors in the treatment of triple-negative breast cancer with homologous repair deficiency

Peng Yuan,  Nan Ma,  Binghe Xu, 
  • Pages: 2774-2792
  • First Published: 24 June 2024

Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases

Sanaz Keshavarz Shahbaz,  Khadije Koushki,  Samaneh Keshavarz Hedayati,  Alice P. McCloskey,  Prashant Kesharwani,  Yazdan Naderi,  Amirhossein Sahebkar, 
  • Pages: 2793-2824
  • First Published: 19 July 2024
Open Access

OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage

Yunxiao Zhong,  Xinya Zhang,  Ruibing Feng,  Yu Fan,  Zhang Zhang,  Qing-Wen Zhang,  Jian-Bo Wan,  Yitao Wang,  Hua Yu,  Guodong Li, 
  • Pages: 2825-2848
  • First Published: 09 August 2024
SIGNIFICANCE STATEMENT

8-oxoguanine DNA glycosylase 1 (OGG1) has emerged as a promising multifunctional therapeutic target for the treatment of oxidative DNA damage-related life-limiting diseases, particularly incurable inflammations, malignant tumors, and age-related disorders, due to its crucial multifunctional role in regulating oxidative DNA damage. As a potential therapeutic target, inhibiting OGG1 may provide a novel approach to prevent and treat inflammation and cancer, while activating OGG1 could be a strategy to prevent age-related disorders.