Pediatric Allergy in the North-American Region

Virtual Issues
2 February 2025
9 July 2025
Pediatric Allergy in the North-American Region promotional image

North America has long been a vibrant hub for groundbreaking research in allergy and immunology driven by its pioneering multiple discoveries in the field, a strong tradition of scientific collaboration, and its rich and diverse patient populations with distinctive environmental exposures.

We are delighted to present this special issue of Pediatric Allergy and Immunology, which provides an inspiring glimpse into the future of pediatric allergy research in North America. The editors of PAI warmly invite researchers from across the region to contribute their work to the journal. We welcome submissions of original research, reviews, and case studies that advance our understanding of pediatric allergies and immunology within the North American context.

Submissions can be made via the Research Exchange Platform and will undergo a thorough peer-review process.

With this Virtual Issue, we feature a set of trailblazing studies which will debut in 2025. This collection highlights innovative research that is set to transform the field and address critical challenges in pediatric allergy and immunology.

We hope that this issue inspires your own work while fostering the understanding of this ever-evolving field.

Warm regards,
Ayobami Akenroye, Guest Editor, Associate Editor, PAI
Carmen Riggioni, Guest Editor, Associate Editor, PAI
Philippe Eigenmann, Editor-in-Chief, PAI

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Original Article:

Immunomodulatory metabolites in IgE-mediated food allergy and oral immunotherapy outcomes based on metabolomic profiling

Yamini V. Virkud,  Jennifer N. Styles,  Rachel S. Kelly,  Sarita U. Patil,  Bert Ruiter,  Neal P. Smith,  Clary Clish,  Craig E. Wheelock,  Juan C. Celedón,  Augusto A. Litonjua,  Supinda Bunyavanich,  Scott T. Weiss,  Erin S. Baker,  Jessica A. Lasky-Su,  Wayne G. Shreffler, 
Immunomodulatory metabolites in IgE-mediated food allergy and oral immunotherapy outcomes based on metabolomic profiling

Association of prenatal vitamin E levels with child asthma and wheeze

Terryl J. Hartman,  Tebeb Gebretsadik,  Margaret A. Adgent,  Marshae Nickelberry,  Paul E. Moore,  Hannah Carlson,  Myron Gross,  Qi Zhao,  Cecelia S. Alcala,  Xueying Zhang,  Nicole R. Bush,  Kaja Z. LeWinn,  Rosalind J. Wright,  Kecia N. Carroll, 

Risk and protective factors of asthma and mental health condition multimorbidity in a national sample of Canadian children

Joshua A. Lawson,  Minyoung Kim,  Parisa Jandaghi,  Donna Goodridge,  Lloyd Balbuena,  Don Cockcroft,  Darryl Adamko,  Ulfat Khanam, 

Open Access

Viral and non-viral episodes of wheezing in early life and the development of asthma and respiratory phenotypes among urban children

Tara N. Havens,  Petra LeBeau,  Agustin Calatroni,  James E. Gern,  George T. O'Connor,  Robert A. Wood,  Carin Lamm,  Rebecca Z. Krouse,  Cynthia M. Visness,  Peter J. Gergen,  Daniel J. Jackson,  Leonard B. Bacharier, 
Open Access

Parent's perception of respiratory syncytial virus and subsequent wheezing burden: A multi-country cross-sectional survey

Adnan Custovic,  Jorge Mestre-Ferrandiz,  Leyla Kragten-Tabatabaie,  Julie Laurent,  Laury Sellem,  Mary Koslap-Petraco,  Chiara Cadeddu, 
Open Access

Innate immune responses are increased in children with acute asthma exacerbation

Shahid Sheikh,  Mariah Eisner,  Joshua Walum,  Kathryn Heyob,  Aiman Q. Khan,  Brandon Lewis,  Mitchell Grayson,  Benjamin Kopp,  Karen McCoy,  Rodney Britt Jr, 
Open Access

Looking for ALPS: The value of a combined assessment of biochemical markers

Isabel Fernandez,  Fabien Touzot, 
Open Access

Benralizumab in children with severe eosinophilic asthma: Pharmacokinetics and long-term safety (TATE study)

H. James Wedner,  Takao Fujisawa,  Theresa W. Guilbert,  Masanori Ikeda,  Vinay Mehta,  Jonathan S. Tam,  Pradeep B. Lukka,  Sara Asimus,  Tomasz Durżyński,  James Johnston,  Wendy I. White,  Mihir Shah,  Viktoria Werkström,  Maria L. Jison,  all TATE investigators , 
Benralizumab in children with severe eosinophilic asthma: Pharmacokinetics and long-term safety (TATE study)

Benralizumab treatment in children demonstrated predictable PK parameters and a reassuring safety profile, consistent with previous studies in adolescents and adults. Treatment with benralizumab resulted in a near-complete reduction in blood eosinophil counts from baseline. Exploratory clinical outcomes indicated numerical improvements in FEV1, CGIC, and PGIC-IA responses, as well as ACQ-IA score and exacerbation rates. Abbreviations: ACQ-IA, Asthma Control Questionnaire-Interviewer administered; BL, baseline; CGIC, Clinician Global Impression of Change; CI, confidence interval; EOT, end of treatment; FEV1, forced expiratory volume in 1 second; PGIC-IA, Patient Global Impression of Change-Interviewer administered; PK, pharmacokinetics; SE, standard error; VPC, visual predictive check.

Open Access

Design of the Intervention to Reduce Early Peanut Allergy in Children (iREACH): A practice-based clinical trial

Lucy A. Bilaver,  Adolfo J. Ariza,  Helen J. Binns,  Jialing Jiang,  Rich Cohn,  Samantha Sansweet,  Haley Hultquist,  Joy Laurienzo Panza,  Alkis Togias,  Ruchi S. Gupta, 
Open Access

Recommendations for asthma monitoring in children: A PeARL document endorsed by APAPARI, EAACI, INTERASMA, REG, and WAO

Nikolaos G. Papadopoulos,  Adnan Custovic,  Antoine Deschildre,  James E. Gern,  Antonio Nieto Garcia,  Michael Miligkos,  Wanda Phipatanakul,  Gary Wong,  Paraskevi Xepapadaki,  Ioana Agache,  Stefania Arasi,  Zeinab Awad El-Sayed,  Leonard B. Bacharier,  Matteo Bonini,  Fulvio Braido,  Davide Caimmi,  Jose A. Castro-Rodriguez,  Zhimin Chen,  Michael Clausen,  Timothy Craig,  Zuzana Diamant,  Francine M. Ducharme,  Motohiro Ebisawa,  Philippe Eigenmann,  Wojciech Feleszko,  Vincezo Fierro,  Alessandro Fiocchi,  Luis Garcia-Marcos,  Anne Goh,  René Maximiliano Gómez,  Maia Gotua,  Eckard Hamelmann,  Gunilla Hedlin,  Elham M. Hossny,  Zhanat Ispayeva,  Daniel J. Jackson,  Tuomas Jartti,  Miloš Jeseňák,  Omer Kalayci,  Alan Kaplan,  Jon R. Konradsen,  Piotr Kuna,  Susanne Lau,  Peter Le Souef,  Robert F. Lemanske,  Michael Levin,  Mika J. Makela,  Alexander G. Mathioudakis,  Oleksandr Mazulov,  Mário Morais-Almeida,  Clare Murray,  Karthik Nagaraju,  Zoltan Novak,  Ruby Pawankar,  Marielle W. Pijnenburg,  Helena Pite,  Paulo M. Pitrez,  Petr Pohunek,  David Price,  Alfred Priftanji,  Valeria Ramiconi,  Daniela Rivero Yeverino,  Graham Roberts,  Aziz Sheikh,  Kun-Ling Shen,  Zsolt Szepfalusi,  Ioanna Tsiligianni,  Mirjana Turkalj,  Steve Turner,  Tetiana Umanets,  Arunas Valiulis,  Susanne Vijveberg,  Jiu-Yao Wang,  Tonya Winders,  Dong Keon Yon,  Osman M. Yusuf,  Heather J. Zar,  WAO Pediatric Asthma Committee , 
Recommendations for asthma monitoring in children: A PeARL document endorsed by APAPARI, EAACI, INTERASMA, REG, and WAO

Pediatric penicillin allergy labels: Influence of race, insurance, and Area Deprivation Index

Zoya Siddiqui,  Brian R. Lee,  Amanda Nedved,  Jennifer McKinsey,  Frances Turcotte Benedict,  Brandi Missel,  Aarti Pandya,  Rana E. El Feghaly, 
Open Access

Asthma and rhinitis control in adolescents and young adults: A real-world MASK-air study

Bernardo Sousa-Pinto,  Arunas Valiulis,  Erik Melén,  Gerard H. Koppelman,  Nikolaos G. Papadopoulos,  Mika Makela,  Tari Haahtela,  Matteo Bonini,  Fulvio Braido,  Luisa Brussino,  Alvaro A. Cruz,  Alessandro Fiocchi,  Mattia Giovannini,  Bilun Gemicioglu,  Marek Kulus,  Piotr Kuna,  Maciej Kupczyk,  Violeta Kvedariene,  Désirée E. Larenas-Linnemann,  Renaud Louis,  Mario Morais-Almeida,  Marek Niedoszytko,  Markus Ollert,  Oliver Pfaar,  Frederico S. Regateiro,  Graham Roberts,  Boleslaw Samolinski,  Marine Savouré,  Luis Taborda-Barata,  Sanna Toppila-Salmi,  Maria Teresa Ventura,  Marta Vazquez-Ortiz,  Rafael José Vieira,  Joao A. Fonseca,  Arzu Yorgancioglu,  Torsten Zuberbier,  Josep M. Anto,  Jean Bousquet,  Nhân Pham-Thi,  the MASK-air think tank , 

Letter:

Social and dietary impacts of food allergies in adolescents: Insights from a US teen survey

Jocelyn Blachar,  Kaci Pickett-Nairne,  Allison Hicks,  Wendy Moore,  Carina Venter,  Panagiota Athanasopoulou, 
Open Access

Anaphylaxis to a blood feeding leech

Carmen H. Li,  Maggie Jiang,  Gabriele Gadermaier,  Sebastian Kvist,  Julia E. M. Upton,  Xiaojun Yin,  Jennifer A. Hoang,  Mikhail Monteiro,  Lisa Hung,  Akash Kothari,  Theo J. Moraes,  Peter Vadas,  Thomas Eiwegger, 
Open Access

The 5–10–15 plan: An approach to managing atopic dermatitis flares in pediatric patients

Nicole Edmonds,  Patricia Zhao,  Aaron D. Smith,  Monica Lawrence,  Barrett J. Zlotoff, 

Unmet social needs and greater symptom burden among children with eosinophilic asthma

Rosemarie de la Rosa,  Adali Martinez,  Morgan Ye,  Danielle Hessler,  Kadiatou Koita,  Monica Bucci,  Dayna Long,  Neeta Thakur, 
Open Access

Early age peanut oral immunotherapy is safe and effective at achieving desensitization in 27 pediatric patients with peanut allergy

Jonathan Hemler,  Samantha Minnicozzi,  Anne Carey,  Karen Braden,  Kelly Boyd, 

Clinical Letter:

Open Access

Omalizumab pretreatment in a case of pediatric carboplatin desensitization

Jeremy Richard Brozyna,  Reena Patel,  William Bradford Fancher,  John Anderson,  Amy CaJacob, 

Systemic JAK inhibitors for treatment of cutaneous manifestations in a patient with SPINK5 variants: A case report and review of the literature

Bridget E. Wilson,  Theresa A. Grebe,  Supraja Prakash,  Cindy S. Bauer,