Pediatric Allergy in the North-American Region

2 February 2025
9 July 2025
Pediatric Allergy in the North-American Region promotional image

North America has long been a vibrant hub for groundbreaking research in allergy and immunology driven by its pioneering multiple discoveries in the field, a strong tradition of scientific collaboration, and its rich and diverse patient populations with distinctive environmental exposures.

We are delighted to present this special issue of Pediatric Allergy and Immunology, which provides an inspiring glimpse into the future of pediatric allergy research in North America. The editors of PAI warmly invite researchers from across the region to contribute their work to the journal. We welcome submissions of original research, reviews, and case studies that advance our understanding of pediatric allergies and immunology within the North American context.

Submissions can be made via the Research Exchange Platform and will undergo a thorough peer-review process.

With this Virtual Issue, we feature a set of trailblazing studies which will debut in 2025. This collection highlights innovative research that is set to transform the field and address critical challenges in pediatric allergy and immunology.

We hope that this issue inspires your own work while fostering the understanding of this ever-evolving field.

Warm regards,
Ayobami Akenroye, Guest Editor, Associate Editor, PAI
Carmen Riggioni, Guest Editor, Associate Editor, PAI
Philippe Eigenmann, Editor-in-Chief, PAI

Editorial Comment:

Review:

Open Access

Transcriptomic changes associated with oral immunotherapy for food allergy

Transcriptomic changes associated with oral immunotherapy for food allergy

In this review we summarise current understanding of immune changes associated with oral immunotherapy (OIT), as established through molecular profiling of the transcriptome. Changes observed during OIT include clonal anergy of T cells with a Th2 phenotype and decreased expression of Th2 genes in peanut reactive T cells. Demethylation of the FOXP3 locus in T regulatory cells has been demonstrated, correlating with treatment outcome. Decreased frequencies of gamma delta T cells have been observed early on in OIT, which may contribute to the loss of Th2 dominance. Multiple single cell studies of CD4+ T cell memory responses have identified a novel subset of a T-helper cells that express type I interferon stimulated genes and may also act to supress Th2.

Original Article: