Table of Contents

Export Citation(s)
Free Access
Front Matter (Pages: i-xix)
I : X-Ray Crystallographic Studies of Ribosomal Subunits
CHAPTER 1
Progress toward the Crystal Structure of a Bacterial 30S Ribosomal Subunit (Pages: 1-9)
V. Ramakrishnan,  Malcolm S. Capel,  William M. Clemons Jr.,  Joanna L. C. May,  Brian T. Wimberly, 
CHAPTER 2
Crystal Structure of the Large Ribosomal Subunit at 5-Angstrom Resolution (Pages: 11-20)
Nenad Ban,  Poul Nissen,  Peter B. Moore,  Thomas A. Steitz, 
CHAPTER 3
Identification of Selected Ribosomal Components in Crystallographic Maps of Prokaryotic Ribosomal Subunits at Medium Resolution (Pages: 21-33)
Anat Bashan,  Marta Pioletti,  Heike Bartels,  Daniela Janell,  Frank Schluenzen,  Marco Gluehmann,  Inna Levin,  Joerg Harms,  Harly A. S. Hansen,  Ante Tocilji,  Tamar Auerbach,  Horacio Avila,  Maria Simitsopoulou,  Moshe Peretz,  William S. Bennett,  Ilana Agmon,  Maggie Kessler,  Shulamith Weinstein,  François Franceschi,  Ada Yonath, 
II : Functional States Mapped by Cryo-Electron Microscopy
CHAPTER 4
Visualization of the Translational Elongation Cycle by Cryo-Electron Microscopy (Pages: 35-44)
Tillmann Pape,  Holger Stark,  Rishi Matadeen,  Elena V. Orlova,  Marin Van Heel, 
CHAPTER 5
Cryo-Electron Microscopy of the Translational Apparatus: Experimental Evidence for the Paths of mRNA, tRNA, and the Polypeptide Chain (Pages: 45-51)
Joachim Frank,  Pawel Penczek,  Robert A. Grassucci,  Amy Heagle,  Christian M. T. Spahn,  Rajendra K. Agrawal, 
CHAPTER 6
Studies of Elongation Factor G-Dependent tRNA Translocation by Three-Dimensional Cryo-Electron Microscopy (Pages: 53-62)
Rajendra K. Agrawal,  Amy B. Heagle,  Joachim Frank, 
III : Structures of Isolated Components
CHAPTER 7
Ribosomal Proteins and Their Structural Transitions on and off the Ribosome (Pages: 63-72)
Salam Al-Karadaghi,  Natalia Davydova,  Irina Eliseikina,  Maria Garber,  Anders Liljas,  Natalia Nevskaya,  Stanislav Nikonov,  Svetlana Tishchenko, 
CHAPTER 8
Structures of Bacterial Ribosomal Proteins: High-Resolution Probes of the Architecture and Mechanism of the Ribosome (Pages: 73-83)
Stephen W. White,  William M. Clemons Jr.,  Christopher Davies,  V. Ramakrishnan,  Brian T. Wimberly, 
CHAPTER 9
Structure and Evolution of the 23S rRNA Binding Domain of Protein L2 (Pages: 85-92)
Isao Tanaka,  Atsushi Nakagawa,  Takashi Nakashima,  Masae Taniguchi,  Harumi Hosaka,  Makoto Kimura, 
CHAPTER 10
How Ribosomal Proteins and rRNA Recognize One Another (Pages: 93-104)
Robert A. Zimmermann,  Irina Alimov,  K. Uma,  Herren Wu,  Iwona Wower,  Edward P. Nikonowicz,  Denis Drygin,  Peining Dong,  Lihong Jiang, 
CHAPTER 11
RNA Tertiary Structure and Protein Recognition in an L11-RNA Complex (Pages: 105-114)
David E. Draper,  Graeme L. Conn,  Apostolos G. Gittis,  Debraj Guhathakurta,  Eaton E. Lattman,  Luis Reynaldo, 
CHAPTER 12
Structure of the Yeast Ribosomal Stalk (Pages: 115-125)
Juan P. G. Ballesta,  Esther Guarinos,  Jesus Zurdo,  Pilar Parada,  Gretel Nusspaumer,  Vassiliki S. Lalioti,  Jorge Perez-Fernandez,  Miguel Remacha, 
IV : Ribosomal Modeling
CHAPTER 13
Studies on the Structure and Function of Ribosomes by Combined Use of Chemical Probing and X-Ray Crystallography (Pages: 127-150)
Harry F. Noller,  Jamie Cate,  Anne Dallas,  Gloria Culver,  Thomas N. Earnest,  Rachel Green,  Lovisa Holmberg,  Simpson Joseph,  Laura Lancaster,  Kate Lieberman,  Chuck Merryman,  Lisa Newcomb,  Raymond Samaha,  Uwe Von Ahsen,  Marat Yusupov,  Gulnara Yusupova,  Kevin Wilson, 
CHAPTER 14
Three-Dimensional Organization of the Bacterial Ribosome and Its Subunits: Transition from Low-Resolution Models to High-Resolution Structures (Pages: 151-163)
Richard Brimacombe,  Barbara Greuer,  Florian Mueller,  Monika Osswald,  Jutta Rinke-Appel,  Ingolf Sommer, 
CHAPTER 15
Functional Interpretation of the Cryo-Electron Microscopy Map of the 30S Ribosomal Subunit from Escherichia coli (Pages: 165-171)
Margaret S. Vanloock,  Arun Malhotra,  David A. Case,  Rajendra K. Agrawal,  Pawel Penczek,  Thomas R. Easterwood,  Joachim Frank,  Stephen C. Harvey, 
V : rRNA Modification and Protein Signals
CHAPTER 16
Bacterial, Archaeal, and Organellar rRNA Pseudouridines and Methylated Nucleosides and Their Enzymes (Pages: 173-189)
James Ofengand,  Kenneth E. Rudd, 
CHAPTER 17
Nucleotide Modifications of Eukaryotic rRNAs: the World of Small Nucleolar RNA Guides Revisited (Pages: 191-203)
Jean-Pierre Bachellerie,  Jérôme Cavaillé,  Liang-Hu Qu, 
CHAPTER 18
Nuclear Import of Ribosomal Proteins: Evidence for a Novel Type of Nuclear Localization Signal (Pages: 205-214)
Rogier Stuger,  Antonius C. J. Timmers,  Hendrik A. Raué,  Jan Van't Riet, 
VI : Probing of Functional Sites
CHAPTER 19
Probing Ribosomal Structure and Function: Analyses with rRNA and Protein Mutants (Pages: 215-227)
Michael O'Connor,  Mark Bayfield,  Steven T. Gregory,  Wyan-Ching Mimi Lee,  J. Stephen Lodmell,  Anuj Mankad,  Jill R. Thompson,  Anton Vila-Sanjurjo,  Catherine L. Squires,  Albert E. Dahlberg, 
CHAPTER 20
Reconstitution of the 50S Subunit with In Vitro-Transcribed 23S rRNA: a New Tool for Studying Peptidyltransferase (Pages: 229-243)
Philipp Khaitovich,  Alexander S. Mankin, 
CHAPTER 21
Modern Site-Directed Cross-Linking Approaches: Implication for Ribosome Structure and Functions (Pages: 245-255)
Alexey A. Bogdanov,  Petr V. Sergiev,  Inna N. Lavrik,  Olga V. Spanchenko,  Andrey A. Leonov,  Olga A. Dontsova, 
CHAPTER 22
Chemical Cleavage as a Probe of Ribosomal Structure (Pages: 257-269)
Walter E. Hill,  Gregory W. Muth,  James M. Bullard,  Scott P. Hennelly,  Jing Yuan,  Wendy T. Grace,  Douglas J. Bucklin,  Michael A. Van Waes,  Charles M. Thompson, 
CHAPTER 23
Applying Photolabile Derivatives of Oligonucleotides To Probe the Peptidyltransferase Center (Pages: 271-285)
Barry S. Cooperman,  Serguei N. Vladimirov,  Yuri Bukhtiyarov,  Zhanna Druzina,  Ruo Wang,  Hyuk-Soo Seo, 
CHAPTER 24
Folding of Nascent Peptides on Ribosomes (Pages: 287-297)
Boyd Hardesty,  Gisela Kramer,  Tamara Tsalkova,  Vasanthi Ramachandiran,  Bryan McIntosh,  Delbert Brod, 
VII : Factor-Mediated Steps in the Elongation Cycle
CHAPTER 25
Mechanisms of Partial Reactions of the Elongation Cycle Catalyzed by Elongation Factors Tu and G (Pages: 299-317)
Marina V. Rodnina,  Tillmann Pape,  Andreas Savelsbergh,  Dagmar Mohr,  Natalia B. Matassova,  Wolfgang Wintermeyer, 
CHAPTER 26
Ribosomal Elongation Cycle (Pages: 319-335)
Knud H. Nierhaus,  Christian Spahn,  Nils Burkhardt,  Marylena Dabrowski,  Gundo Diedrich,  Edda Einfeldt,  Detlev Kamp,  Viter Marquez,  Sebastian Patzke,  Markus A. Schäfer,  Ulrich Stelzl,  Gregor Blaha,  Regine Willumeit,  Heinrich B. Stuhrmann, 
CHAPTER 27
Ternary Complex of EF-Tu and Its Action on the Ribosome (Pages: 337-345)
Gregers R. Andersen,  Victor G. Stepanov,  Morten Kjeldgaard,  Søren S. Thirup,  Jens Nyborg, 
CHAPTER 28
Insights into the GTPase Mechanism of EF-Tu from Structural Studies (Pages: 347-357)
Rolf Hilgenfeld,  Jeroen Mesters,  Tanis Hogg, 
CHAPTER 29
The States, Conformational Dynamics, and Fusidic Acid-Resistant Mutants of Elongation Factor G (Pages: 359-365)
Anders Liljas,  Ole Kristensen,  Martin Laurberg,  Salam Al-Karadaghi,  Anatoly Gudkov,  Kirill Martemyanov,  Diarmaid Hughes,  Ivan Nagaev, 
VIII : mRNA Decoding
CHAPTER 30
Poking a Hole in the Sanctity of the Triplet Code: Inferences for Framing (Pages: 367-383)
John F. Atkins,  Alan J. Herr,  Christian Massire,  Michael OʼConnor,  Ivaylo Ivanov,  Raymond F. Gesteland, 
CHAPTER 31
The Unbearable Lightness of Peptidyl-tRNA (Pages: 385-396)
Jonathan Gallant,  Dale Lindsley,  Judy Masucci, 
CHAPTER 32
tmRNA: a Case of Structural and Functional Mimicry on and off the Ribosome? (Pages: 397-405)
Jacek Wower,  Christian Zwieb,  Iwona K. Wower, 
IX : Functional Target Sites for Antibiotics and Ribotoxins
CHAPTER 33
Antibiotic Biosynthesis: Some Thoughts on “Why?” and “How?” (Pages: 407-417)
Eric Cundliffe, 
CHAPTER 34
Aminoglycoside Antibiotics and Decoding (Pages: 419-429)
Joseph D. Puglisi,  Scott C. Blanchard,  Kam D. Dahlquist,  Robert G. Eason,  Dominique Fourmy,  Stephen R. Lynch,  Michael I. Recht,  Satoko Yoshizawa, 
CHAPTER 35
Macrolide Resistance Conferred by Alterations in the Ribosome Target Site (Pages: 431-439)
Stephen Douthwaite,  Birte Vester, 
CHAPTER 36
Antibiotics and the Peptidyltransferase Center (Pages: 441-449)
Bo T. Porse,  Stanislav V. Kirillov,  Roger A. Garrett, 
CHAPTER 37
Structures and Properties of Ribotoxins (Pages: 451-460)
Richard Kao,  Julian Davies, 
CHAPTER 38
Structure and Function of the Sarcin-Ricin Domain (Pages: 461-473)
Ira G. Wool,  Carl C. Correll,  Yuen-Ling Chan, 
X : Initiation, Termination, and Recycling
CHAPTER 39
Translation Initiation in Bacteria (Pages: 475-494)
Claudio O. Gualerzi,  Letizia Brandi,  Enrico Caserta,  Anna La Teana,  Roberto Spurio,  Jerneja Tomšic,  Cynthia L. Pon, 
CHAPTER 40
Factor-Mediated Termination of Protein Synthesis: a Welcome Return to the Mainstream of Translation (Pages: 495-508)
Daniel N. Wilson,  Mark E. Dalphin,  Herman J. Pel,  Lousie L. Major,  John B. Mansell,  Warren P. Tate, 
CHAPTER 41
rRNA Functional Sites and Structures for Peptide Chain Termination (Pages: 509-518)
Emanuel J. Murgola,  Alexey L. Arkov,  Natalya S. Chernyaeva,  Klas O. F. Hedenstierna,  Frances T. Pagel, 
CHAPTER 42
Genetic Probes to Bacterial Release Factors: tRNA Mimicry Hypothesis and Beyond (Pages: 519-526)
Yoshikazu Nakamura,  Yoichi Kawazu,  Makiko Uno,  Kuniyasu Yoshimura,  Koichi Ito, 
CHAPTER 43
Ribosome-Recycling Factor: an Essential Factor for Protein Synthesis (Pages: 527-539)
Akira Kaji,  Go Hirokawa, 
CHAPTER 44
Mechanism of Bacterial Translation Termination and Ribosome Recycling (Pages: 541-551)
Måns Ehrenberg,  Vildan Dincbas,  David Freistroffer,  Valerie Heurgué-Hamard,  Reza Karimi,  Michael Pavlov,  Richard H. Buckingham, 
XI : In Conclusion
CHAPTER 45
Concluding Remarks for the Helsingør Ribosome Conference, 13 to 17 June 1999 (Pages: 553-556)
Peter B. Moore, 
Free Access
Index (Pages: 557-565)