There is a dynamic, bi-directional relationship between aging and cancer.

This is a review on the effects of aging on biliary tract cancer (BTC). We discuss the potential link between aging and BTC from the aspects of molecular mechanisms (including the DNA damage repair (DDR), cell senescence and the tumour microenvironment (TME)) and clinical challenges.

This analysis of a population dataset, the SEER Medicare database, evaluates the use of standard chemotherapy, modified chemotherapy and no chemotherapy for older adults with advanced bladder cancer. Most patients do not receive any chemotherapy. We performed a latent class analysis of events of functional importance to further explore this yet this is an area that warrants further research into how patients and care providers decide on treatment plans.

Age is a significant risk factor for ovarian cancer (OC), and preclinical models show enhanced metastatic success in aged (A) mice relative to young (Y). Intratumoral collagen remodeling was enhanced in A mice, while peritumoral collagen was remodeled more extensively in Y mice. Age-associated changes in omental ultrastructure and collagen organization were observed in tumor naïve mice, suggesting the development of a permissive premetastatic niche contributing to enhanced metastatic success in the aged host.