We established a robust and sensitive androgen response element luciferase reporter assay to monitor androgen receptor (AR) activity using KUCaP13 cells, a novel human-derived treatment-related neuroendocrine prostate cancer (t-NEPC) cell line. A high-throughput screening using a chemical library to identify potential compounds that induce AR re-expression in KUCaP13 cells revealed 30 candidate molecules potentially enhancing luciferase luminescence; however, subsequent validation steps demonstrated these signals to be false-positives. Despite not achieving the goal of AR re-expression, this study stands as a significant proof-of-concept for the application of high-throughput screening approaches in t-NEPC research.

Chlorophyllin is an orally administered phytopharmaceutical that has anti-inflammatory effects. In the current phase 2 study, the efficacy of CHL will be investigated in both symptomatic and asymptomatic radionecrosis, with clinico-radiological response at 1 month as the primary endpoint.

Isoliquiritigenin (ISL) increased cytosol calcium and induced apoptosis in colon cancer cells via transient receptor potential vanilloid-1 (TRPV1). CapZ, capsazepine; ISL, isoliquiritigenin; TRPV1, transient receptor potential vanilloid-1. Created in BioRender.com.

Within the European PanCareFollowUp project, an eHealth lifestyle intervention was developed to guide survivors of childhood, adolescent and young adult cancer in adopting healthier behaviours. Results from this efficacy analysis are positive and can be used for further study and implementation.

RNA sequencing in a large series of B-cell precursor acute lymphoblastic leukemia cell lines was performed. Using the data, a close association between types of fusion genes and patterns of gene expression was demonstrated. Furthermore, several cell cycle-related genes that were correlated with cell cycle progression and relapsed-related genes that were associated with disease relapse in the clinical samples were identified.

A minority of oncologic studies utilizing AI analyzed in this review reported the racial and ethnic demographic data of participants included in their training and validation sets. In studies that did report racial demographic data, few non-white patients were included in the datasets.

This study highlights the significant impact of bone metastasis on the prognosis of early-onset gastric cancer (EOGC). Patients with bone metastasis exhibit a unique pathological profile characterized by immune suppression, inflammatory activation, and coagulation imbalances, creating an environment that promotes tumor progression. Key findings include elevated pro-inflammatory cytokines and coagulation markers, emphasizing the need for targeted therapeutic strategies to improve outcomes in bone metastatic early-onset gastric cancer patients.

The combination of TKI and ICI for uHCC after LEN failure demonstrated great survival benefits and was well tolerated, irrespective of the second-line TKI administered.

Because Trop-2 ADC targeting is highly promising in TNBC, we aimed at clarifying Trop-2 expression clinicopathological correlations. Trop-2 protein expression appeared nearly constant in TNBC, independent of classical risk variables and outcome. This is favorable to multiple therapeutic associations of anti-Trop-2 ADC with other drugs and avoids splintering the patient population in subclasses.

This study presents a novel and interpretable approach to accurately predicting the neoplastic nature of gallbladder polyps (GBPs). We developed and validated interpretable machine learning (ML) models using data from 924 patients with GBPs who underwent cholecystectomy. Nine ML algorithms were employed, with the K-nearest neighbors, C5.0 decision tree algorithm and gradient boosting machine models demonstrating the highest predictive efficacy for neoplastic polyps.

Individual- and neighborhood-level factors mediate the observed racial inequities in the quality of non-small cell lung cancer (NSCLC) care, and their effects vary based on the phase of cancer care. The design of interventions addressing these structural drivers of inequitable care should be tailored based on the phase of NSCLC care.

Cholesterol manipulation has recently been associated with enhanced responses to immunotherapy. Review of clinical outcomes among patients treated with immune checkpoint blockade for head and neck cancer at our institution shows that statin use was independently associated with an objective response, but no significant increase in survival.

Short-term radiation therapy induces oncogenic AF1q expression in rectal cancer that correlates with negative lymph node stage AF1q expression associates with high STAT1 and low IDO1 expression in irradiated tumor samples The favorable effects of short-term radiation therapy on tumor biology might be enhanced by an AF1q-driven pro-apoptotic signaling axis AF1q may be a promising therapeutic target responsive to radiation therapy.

Here, we identified the low expression pattern of RNA-binding protein Arid4a in human breast cancers and its potential role in modulating tumor metastasis-related gene expression and tumor progression. Mechanistically, Arid4a could upregulate the expression of metastasis-suppressing genes by stabilizing their mRNAs via binding to the stem–loop structure localized in 3′ UTR.

Activity and mood-related interference is common in primary brain tumor patients. Severity is associated with both clinical factors (diagnosis, number of surgeries) and social determinants of health (rural disparities).