Highlights

• There is significant decrease in pain score and symptom score like diabetic neuropathy symptoms, diabetic neuropathy examination, and neuropathic disability score with duloxetine and gabapentin.
• Equivalence of duloxetine with gabapentin was established with regard to Visual Analogue Scale (VAS) scores.
• Meta-analysis of studies showed comparable efficacy of duloxetine vs gabapentin in terms of VAS scores.

Highlights

• Provide key information on the pathogenicity of ABCC8 variants in Chinese early onset diabetes.
• Eight missense ABCC8 variants classified as likely pathogenic were identified, and the phenotypes caused by these variants were variable.

Highlights

• Choline is a major dietary precursor for gut microbiome-derived trimethylamine, but little is known about the relationship between dietary intake of choline and diabetes mellitus.
• There is a linear dose–response relationship between dietary choline intake and the odds of diabetes mellitus.
• Dietary choline should not exceed 331.7 mg/8.37-MJ per day for US adults to achieve potentially lower risks of diabetes mellitus.

Highlights

• Several psychiatric disorders were associated with levothyroxine therapy (LT4).
• Depression, anxiety disorders, and attention-deficit/hyperactivity disorder showed the strongest relation to LT4.
• Thyroid autoimmunity itself (no LT4) was not associated with psychiatric disorders.

Highlights

• The prognostic value of combining tubular basement membrane (TBM) and glomerular basement membrane (GBM) in diabetic nephropathy (DN) was lacking.
• TBM thickness was strongly correlated with GBM thickness, baseline estimated glomerular filtration rate, and proteinuria.
• The degree of TBM thickness provided additional value to GBM thickness for predicting end-stage renal disease progression in patients with type 2 diabetes and biopsy-proven DN.

Highlights

• Coronavirus disease 2019 (COVID-19) takes an unfavorable course in patients with type 2 diabetes mellitus (T2DM), and the risk increases in individuals with certain conditions, some of which are not modifiable.
• This study showed significantly higher mortality due to COVID-19 in hospitalized patients with T2DM than without (13.6% vs 8.7%; hazard ratio 1.75; 95% CI, 1.58-1.93).
• Older age, male gender, obesity, preexisting insulin treatment, low lymphocyte count, and pulmonary involvement on admission were the significant associates of COVID-19 mortality.

Highlights

• The beneficial cardiovascular (CV) effects of SGLT-2 inhibitors (SGLT-2i) in patients with heart failure are already known.
• Whether SGLT-2i exert similar CV effects in heart failure with reduced or preserved ejection fraction is not known.
• This meta-analysis showed SGLT-2i exert similar CV benefits irrespective of the types of heart failure. Future trials will confirm or refute the CV effects of SGLT-2i in patients with heart failure with preserved ejection fraction.