Highlights

• Even without progressing to type 2 diabetes, gestational hyperglycemia is associated with an increased risk of cardiovascular disease (CVD).
• The association between gestational hyperglycemia and CVD risk could be modified by lifestyle factors and hypertension.
• Subsequent blood pressure management and lifestyle intervention for women with gestational hyperglycemia are important approaches to prevent CVD.

Highlights

• Among patients with clinically diagnosed type 2 diabetes, the proportion of postpancreatitis diabetes mellitus (PPDM) is ~1.5% in an everyday clinical care setting.
• Glucose metabolism of PPDM folowing acute pancreatitis is largely indistinguishable from T2D, whereas PPDM associated with chronic pancreatitis differs in relation to insulin secretion, insulin sensitivity, and glycemic control.

Highlights

• Type 2 diabetes mellitus (T2DM) probability was decreased with rs2283228 of KCNQ1.
• A combination of rs2237895 with body mass index, hypertension, and hypertriglyceridemia existed.
• T2DM probability was associated with methylation of two CpG sites of KCNQ1.

Highlights

• A younger age at diagnosis of type 2 diabetes is associated with a more significantly elevated risk of albuminuria than an older age at diagnosis in Chinese adults, after fully excluding the confounding effect of actual age or diabetes duration.
• Young adults diagnosed with diabetes were more likely to have an unfavorable metabolic profile compared with normal controls.
• The age at diabetes diagnosis should be considered when evaluating the risk of developing albuminuria in diabetes patients.

Highlights

• Boys with type 1 diabetes diagnosed before puberty achieved a final height that was similar to that of their target height and the general population.
• The association of good glycemic control with higher total pubertal growth and final height highlights the importance of maintaining tight glycemic control, especially during the stages of maximal growth when boys may be particularly vulnerable.

Highlights

• This prospective study compares 15 patients with immune-checkpoint induced diabetes mellitus (CPI-DM) with a propensity score matched cohort of patients with other diabetes types. Diabetic ketoacidosis at onset and autoimmune comorbidity is more frequent in CPI-DM patients. This can be avoided by regular glucose measurements and education on hyperglycemia.

Highlights

• The combination of low appendicular skeletal muscle mass (ASM) adjusted with body mass index (ASM/BMI; short: SM) and low grip strength (GS) was more strongly related to cardiovascular disease (CVD), coronary heart disease (CHD), and peripheral arterial disease compared with either low SM or low GS in type 2 diabetic patients.
• The combined associations of SM and GS with CVD and CHD were more prominent in individuals with glycosylated hemoglobin (HbA1c) ≥ 7.1% than those with HbA1c < 7.1%, indicating that glucose control is critical for ASM and GS.

Highlights

• Increases in creatinine-to-cystatin C ratio over 4-year were associated with lower risk of diabetes in middle-aged and older adults.
• Increases in creatinine-to-cystatin C ratio were associated with a favorable cardiometabolic profile at the 4-year follow-up.
• Increases in creatinine-to-cystatin C ratio may benefit cardiometabolic control by improving glycemic control and lowering the degree of inflammation.

Highlights

• The impact of stress-induced hyperglycemia on outcome is poorly reflected by absolute glucose levels.
• The stress hyperglycemia ratio (SHR) biomarker discriminates between interpatient variation in normal premorbid background glycemia related to glycosylated hemoglobin and the acute relative increase in glucose related to physiological stress that truly represents stress-induced hyperglycemia.
• SHR at admission was superior to glucose in predicting ischemic stroke outcome.
• There is a need for interventional studies based on SHR rather than glucose to best assess management of stress-induced hyperglycemia.

Highlights

• Prior studies have reported an association between cardiovascular disease and risk of incident diabetes mellitus. However, factors that may explain the association remain unclear.
• Using propensity score matching, we reinforced the concern that cardiovascular disease may increase the risk of developing diabetes mellitus.
• We further showed that the association between cardiovascular disease and incident diabetes mellitus was partially explained by cardiovascular medications such as beta-blockers, statins, and diuretics.

Highlights

• At the time of gestational diabetes mellitus (GDM) diagnosis, gut dysbiosis was severer in mothers who ended up with diet control failure than those who ended up with successful diet control.
• This finding was noticed even when the glycemic profile at the time of GDM diagnosis was similar between these two groups.
• Interestingly, gut dysbiosis in GDM mothers with diet control failure was shown associated with gut dysbiosis in their newborns.