Highlights

• This study examined the interaction between high alcohol frequency and a high number of depressive symptoms on the development of neuropathy, retinopathy, nephropathy, and coronary artery disease in individuals with type 2 diabetes mellitus (T2DM).
• Individuals with high depressive symptoms who drank the most frequently had the highest risk of incident neuropathy and coronary artery disease.
• Future prevention efforts should examine both alcohol frequency and depressive symptoms when assessing the risk of neuropathy and coronary artery disease among individuals with T2DM.

Highlights

• Continuous glucose monitoring (CGM) overcomes problems inherent in HbA1c by providing glucose-centric metrics and actionable information to healthcare providers and their patients, leading to improved glycemic control.
• In addition, CGM is the key technology is driving advances to a fully closed-loop artificial pancreas system.

Highlights

• N-Acetylcysteine (NAC) treatment improved gut dysbiosis and glucose metabolic disorder in high-fat diet-fed mice.
• In mice with metabolic syndrome, NAC boosted the growth of Akkermansia, Bifidobacterium, Allobaculum, and Lactobacillus.
• The changes in gut microbiota abundance after NAC treatment were associated with altered metabolic biomarkers.

Highlights

• This study presents details of six peripubertal cases with clinically diagnosed Type A insulin resistance (IR), including four cases with identified insulin receptor (INSR) gene mutations (three previously reported and one novel).
• The study reveals the clinical features of patients with Type A IR due to INSR mutations compared with mutation-negative patients, and indicates that the extent of growth retardation during the fetal period is correlated with the severity of insulin signaling impairment.

Highlights

• Low birth weight was linked with lower body mass index, a smaller waist circumference, and larger waist:  hip and waist:  height ratios in the Chinese population.
• The non-linear pattern of associations between birth weight and body size in adulthood in this population, as well as the higher risks of type 2 diabetes mellitus and hypertension in men and women with low birth weight, suggest that nutrition in early life is of considerable importance to health in later life.

Highlights

• Among all patients with diabetes, 88.6% have certain comorbid conditions. Approximately 40.5% have diabetes-associated conditions (concordant comorbidity) and 48.1% have conditions not related to diabetes (discordant comorbidity).
• Patients with diabetes only spent less money on medical-related expenses, but received worse diabetes care than patients with comorbid conditions.
• Higher disease burden in terms of medical expenditure and health-related quality of life in patients with diabetes was associated more with discordant than concordant comorbidity.

Highlights

• Left atrial appendage occlusion (LAAO) in diabetes mellitus (DM) patients with atrial fibrillation has similar safety endpoints and long-term efficacy as LAAO in the general population.
• In addition, LAAO in DM patients with AF has similar stroke and bleeding prevention rates as in patients without DM.

Highlights

• This study reports a novel frameshift mutation c.212dupG (p.Gly73fs) in the insulin (INS) gene causing maturity onset diabetes of the young (MODY) 10, one of the rare types of MODY, identified in seven family members.
• Screening for mutations in identified MODY genes is warranted in patients who require insulin, are negative for autoantibodies but have a family history of diabetes.

Highlights

• Former smokers exhibited a significantly higher metabolic risk compared with subjects with other smoking habits.
• Current smokers with diabetes exhibited significantly higher fasting blood glucose and triglyceride levels.
• Only former smoking was independently associated with increased dysglycemic risk after adjustment for potential confounders

Highlights

• Concomitant elevated expression of Caspase-1 in respect of reduced eGFR among DN may serve as better explainable marker for the adverse prognosis of the disease
• Study may open new horizon to understand patho-mechanism with the aid of Inflammasome-complex.