Highlights

• Digital therapy is gaining a pivotal role in the care of patients with diabetes at all levels of disease.
• Thousands of mobile apps are available for enhancing patient motivation, disease management and data provision, presentation, and analysis.
• Data management systems will handle the multitude of data generated daily by patients’ insulin and glucose monitors and other wearables, and decision support systems may, in future, incorporate all data to provide timely and relevant clinical recommendations.
• Future challenges include aspects of data filtering, access, privacy, and regulation.

Highlights

• The aqueous leaf extract of P. sapota and biologically synthesized silver nanoparticles play an important role in regulating glucose metabolism.
• Determining the role of P. sapota leaf extract in regulating glucose metabolism will provide new insights into the treatment of diabetes, as well as the role of silver nanoparticles in curbing the disease.

Highlights

• The PRKAA2 single nucleotide polymorphisms (SNPs) rs10789038 and rs2796498 were found to be associated with susceptibility to type 2 diabetes mellitus (T2DM).
• These two SNPs seem to interact with the rs2746342 SNP of PRKAA2 to affect the development of T2DM.
• The present study is the first to find a significant association between rs2796498 and the incidence of diabetic nephropathy in the Chinese Han population.

Highlights

• A novel SLC19A2 mutation (c.848G>A; p.W283X), inherited as segmental uniparental isodisomy, was identified in a patient with permanent neonatal diabetes mellitus (PNDM).
• The insulin insufficiency in this patient with SLC19A2 deficiency was corrected by thiamine supplementation.
• A differential diagnosis of SLC19A2 deficiency should be considered for children with PNDM accompanied by anemia or hearing defects to allow for early treatment.

Highlights

• In a cohort of 17 803 Chinese pregnant women from Tianjin, China, body mass index (BMI) between ≥22.5 and <24.0 kg/m² and waist circumference between ≥78.5 and <85.0 cm measured up to 12 weeks gestation were independently associated with increased risks of gestational diabetes mellitus (GDM).
• The presence of BMI ≥22.5 kg/m² and waist circumference ≥78.5 cm interacted to further increase the risk of GDM.

Highlights

• Add-on therapy with vildagliptin to a metformin monotherapy regimen in uncontrolled type 2 diabetes mellitus (T2DM) patients is associated with a significant improvement in glycemic control, with no apparent increase in body weight.
• The real-world efficacy of vildagliptin as an add-on therapy to metformin is similar to that calculated in randomized controlled trials.

Highlights

• The findings of the present study suggest that different aerobic exercise frequencies improve diabetes markers and skeletal muscle damage in streptozotocin–nicotinamide-induced type 2 diabetes mellitus rats.
• The outcomes of different exercise modalities did not differ significantly from each other, provided that the total duration of the exercise remained constant.