THIS ARTICLE HAS BEEN RETRACTED
Retracted: Evaluation of antidiabetic activity of biologically synthesized silver nanoparticles using Pouteria sapota in streptozotocin-induced diabetic rats
在链脲霉素-诱导的糖尿病大鼠中评估使用山榄果生物合成的银纳米粒子的降糖活性
Correction(s) for this article
-
Erratum
- Volume 12Issue 1Journal of Diabetes
- pages: 95-95
- First Published online: December 19, 2019
Retraction(s) for this article
-
RETRACTION
- Volume 13Issue 5Journal of Diabetes
- pages: 442-442
- First Published online: March 24, 2021
Sathya Prabhu,
Shanmugam Vinodhini,
Chakravarthy Elanchezhiyan,
Devi Rajeswari,
Sathya Prabhu
Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, Vellore, India
Search for more papers by this authorShanmugam Vinodhini
Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, Vellore, India
Search for more papers by this authorChakravarthy Elanchezhiyan
Department of Zoology, Annamalai University, Chidambaram, India
Search for more papers by this authorCorresponding Author
Devi Rajeswari
Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, Vellore, India
Correspondence
Devi Rajeswari, Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, Vellore 14, Tamil Nadu, India.
Tel: +91 9500328996
Fax: +91 416 2243092
Email: [email protected]
Search for more papers by this authorSathya Prabhu,
Shanmugam Vinodhini,
Chakravarthy Elanchezhiyan,
Devi Rajeswari,
Sathya Prabhu
Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, Vellore, India
Search for more papers by this authorShanmugam Vinodhini
Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, Vellore, India
Search for more papers by this authorChakravarthy Elanchezhiyan
Department of Zoology, Annamalai University, Chidambaram, India
Search for more papers by this authorCorresponding Author
Devi Rajeswari
Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, Vellore, India
Correspondence
Devi Rajeswari, Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, Vellore 14, Tamil Nadu, India.
Tel: +91 9500328996
Fax: +91 416 2243092
Email: [email protected]
Search for more papers by this authorAbstract
enBackground
Medicinal plants and green synthesis of silver nanoparticles (AgNPs) have proven to be good sources of agents effective in the treatment of diabetes mellitus. The present study focused on the green synthesis of AgNPs from the aqueous leaf extract of Pouteria sapota in order to evaluate the in vitro and in vivo antidiabetic properties of this extract and the synthesized AgNPs.
Methods
The AgNPs were biologically synthesized under ambient conditions from an aqueous leaf extract of P. sapota using the hot percolation method and were characterized using spectroscopic methods, X-ray diffraction, and scanning electron microscopy. The in vitro antidiabetic activity of the aqueous leaf extract and AgNPs was confirmed by non-enzymatic glycosylation of hemoglobin, glucose uptake by yeast cells following exposure of cells to 5 or 10 mmol/L glucose solution, and inhibition of α-amylase. Further, in vivo antidiabetic activity was assessed in streptozotocin-induced rats. Rats were treated with aqueous leaf extract (100 mg/kg) or AgNPs (10 mg/kg) for 28 days. Following treatment, rats were killed for biochemical and histopathological analysis of kidney and liver samples.
Results
A significant reduction in blood sugar levels was noted in rats treated with leaf extract or AgNPs. Results of in vitro and in vivo analyses in rats treated with leaf extract or AgNPs show that both the extract and the biologically synthesized AgNPs have antidiabetic activity.
Conclusion
The aqueous leaf extract of P. sapota and AgNPs exhibited efficient antidiabetic activity in the rat model of diabetes and therefore could have potential for development for medical applications in the future.
摘要
zh背景
药用植物以及绿色合成的银纳米颗粒(silver nanoparticles, AgNPs)目前都已被证实是有效治疗糖尿病的药物来源。当前这项研究聚焦于来源于山榄果水叶提取物的绿色合成(生物合成)的AgNPs, 评估提取物与合成的AgNPs在体外以及体内的降糖活性。
方法
使用热渗透法在生物环境条件下从山榄果水叶提取物中合成AgNPs, 以光谱法、X射线衍射以及扫描电子显微镜描述其特征。以非酶糖化血红蛋白的变化确认水叶提取物与AgNPs的体外降糖活性, 将酵母细胞暴露在5或者10 mmol/L的葡萄糖溶液中并加入α-淀粉酶抑制剂, 测定细胞所摄取的葡萄糖。进一步在链脲霉素-诱导的糖尿病大鼠中评估体内降糖活性。大鼠使用水叶提取物(100 mg/kg)或AgNPs(10 mg/kg)共治疗28天。治疗结束后, 处死大鼠进行肾脏与肝脏样本的生化以及组织病理学分析。
结果
大鼠使用水叶提取物或者AgNPs治疗后血糖水平均显著下降。接受叶提取物或者AgNPs治疗大鼠的体外以及体内分析结果表明, 提取物与生物合成的AgNPs都具有降糖活性。
结论
在糖尿病大鼠模型中山榄果水叶提取物与AgNPs都表现出了有效的降糖活性, 将来可能具有药用的发展潜力。
Supporting Information
| Filename | Description |
|---|---|
| jdb12554-sup-0001-FileS1.docxWord 2007 document , 19 KB | File S1. Synthesis and characterization of AgNPs from P. sapota. |
| jdb12554-sup-0002-FigureS1.jpgJPEG image, 32.1 KB | Figure S1. UV - Visible spectroscopy of biologically synthesized AgNPs from P. sapota. |
| jdb12554-sup-0003-FigureS2.jpgJPEG image, 101 KB | Figure S2. FTIR analysis of biologically synthesized AgNPs from P. sapota. |
| jdb12554-sup-0004-FigureS3.jpgJPEG image, 54.4 KB | Figure S3. The EDX results of biologically synthesized AgNPs from P. sapota. |
| jdb12554-sup-0005-FigureS4.jpgJPEG image, 69.4 KB | Figure S4. Scanning electron microscope (SEM) images of biologically synthesized AgNPs from P. sapota. |
| jdb12554-sup-0006-FigureS5.jpgJPEG image, 119.9 KB | Figure S5. The X-ray diffraction (XRD) of biologically synthesized AgNPs. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- 1 Patel D, Kumar R, Prasad SK, Sairam K, Hemalatha S. Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus (Linn) F. Muell in streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed. 2011; 1: 316–322.
- 2 World Health Organization (WHO). WHO Traditional Medicine Strategy 2002–2005. WHO, Geneva; 2002.
- 3 Dobs AS, Goldstein BJ, Aschner P et al. Efficacy and safety of sitagliptin added to ongoing metformin and rosiglitazone combination therapy in a randomized placebo-controlled 54-week trial in patients with type 2 diabetes. J Diabetes. 2013; 5: 68–79.
- 4 Patel D, Prasad S, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed. 2012; 2: 320–330.
- 5 Nabeel MA, Kathiresan K, Manivannan S. Antidiabetic activity of the mangrove species Ceriops decandra in alloxan-induced diabetic rats. J Diabetes. 2010; 2: 97–103.
- 6 Gajalakshmi S, Vijayalakshmi S, Rajeswari VD. Phytochemical and pharmacological properties of Annona muricata: A review. Int J Pharm Pharm Sci. 2012; 4: 3–6.
- 7 Rajeswari VD, Lavinya BU, Akalya J, Srujana KSL, Sabina EP, Rajeswari VD. Appraisal of the in vitro antibacterial and antioxidant potential of the leaf extracts of Cadaba fruticosa . Asian J Pharm Clin Res. 2014; 7: 118–120.
- 8 Gholami-Ahangaran M, Bahmani M, Zia-Jahromi N. Comparative and evaluation of anti-leech (Limnatis nilotica) effect of olive (Olea europaea L. ) with levamisol and tiabendazole. Asian Pac J Trop Dis. 2012; 2 (Suppl): S101–S103.
- 9 Singh LW. Traditional medicinal plants of Manipur as anti-diabetics. J Med Plants Res. 2011; 5: 677–687.
- 10 Malviya N, Jain S, Malviya S. Antidiabetic potential of medicinal plants. Acta Pol Pharm. 2010; 67: 113–118.
- 11 Chauhan A, Sharma PK, Srivastava P, Kumar N, Dudhe R. Plants having potential antidiabetic activity: A review. Pharm Lett. 2010; 2: 369–387.
- 12 Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TPA. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007; 40: 163–173.
- 13 Hannan JM, Marenah L, Ali L, Rokeya B, Flatt PR, Abdel WYH. Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic β-cells. J Endocrinol. 2007; 192: 159–168.
- 14 Alia-Tejacal I, Villanueva-Arce R, Pelayo-Zaldívar C, Colinas-Leon MT, Martinez-Damian MT. Postharvest physiology and technology of sapote mamey fruit (Pouteria sapota (Jacq.) HE Moore & Stearn). Postharvest Biol Technol. 2007; 45: 285–297.
- 15 Ma J, Yang H, Basile MJ, Kennelly EJ. Analysis of polyphenolic antioxidants from the fruits of three Pouteria species by selected ion monitoring liquid chromatography–mass spectrometry. J Agric Food Chem. 2004; 52: 5873–5878.
- 16 Mahattanatawee K, Manthey JA, Luzio G, Talcott ST, Goodner K, Baldwin EA. Total antioxidant activity and fiber content of select Florida-grown tropical fruits. J Agric Food Chem. 2006; 54: 7355–7363.
- 17 Otari SV, Patil RM, Ghosh SJ, Pawar SH. Green phytosynthesis of silver nanoparticles using aqueous extract of Manilkara zapota (L.) seeds and its inhibitory action against Candida species. Mater Lett. 2014; 116: 367–369.
- 18 van der Zande M, Vandebriel RJ, Van Doren E et al. Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure. ACS Nano. 2012; 6: 7427–7442.
- 19 Lankveld D, Oomen A, Krystek P et al. The kinetics of the tissue distribution of silver nanoparticles of different sizes. Biomaterials. 2010; 31: 8350–8361.
- 20 Williams K, Milner J, Boudrau MD, Gokulan K, Cerniglia CE, Khare S. Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats. Nanotoxicology. 2015; 9: 279–289.
- 21 Sung JH, Ji JH, Park JD et al. Subchronic inhalation toxicity of silver nanoparticles. Toxicology. 2009; 108: 452–461.
- 22 Lee JH, Kim YS, Song KS et al. Biopersistence of silver nanoparticles in tissues from Sprague-Dawley rats. Part Fibre Toxicol. 2013; 10: 1–14.
- 23 Zhang XF, Liu ZG, Shen W et al. Silver nanoparticles: Synthesis, characterization, properties, applications, and therapeutic approaches. Int J Mol Sci. 2016; 17: 1501–1534.
- 24 Srikar SK, Giri DD, Pal DB, Mishra PK, Upadhyay SN. Green synthesis of silver nanoparticles: A review. Green Sustainable Chem. 2016; 6: 34–56.
- 25 Dziendzikowska K, Gromadzka OJ, Lankoff A et al. Time dependent biodistribution and excretion of silver nanoparticles in male Wistar rats. J Appl Toxicol. 2012; 32: 920–928.
- 26 Mittal AK, Bhaumik J, Kumar S, Banerjee UC. Biosynthesis of silver nanoparticles: Elucidation of prospective mechanism and therapeutic potential. J Colloid Interface Sci. 2014; 1: 39–47.
- 27 Afifi M, Abdelazim AM. Ameliorative effect of zinc oxide and silver nanoparticles on antioxidant system in the brain of diabetic rats. Asian Pac J Trop Biomed. 2015; 5: 874–877.
- 28 Müller J, Heindl A. Drying of medicinal plants. In: Bogers RJ, L.E. Craker LE, Lange D (eds). Medicinal and Aromatic Plants. Springer, Netherland, 2006: 237–252.
- 29 World Health Organization (WHO). WHO Guidelines on Good Agricultural and Collection Practices (GACP) for Medicinal Plants. WHO, Geneva, 2003.
- 30 Wang L, Weller CL. Recent advances in extraction of nutraceuticals from plants. Trends Food Sci Technol. 2006; 17: 300–312.
- 31 Benthin B, Danz H, Hamburger M. Pressurized liquid extraction of medicinal plants. J Chromatogr A. 1999; 837: 211–219.
- 32 Yadav R, Agarwala M. Phytochemical analysis of some medicinal plants. J Phytology. 2011; 3: 10–14.
- 33 Shalini S, Sampathkumar P. Phytochemical screening and antimicrobial activity of plant extracts for disease management. Int J Curr Sci. 2012; 2: 209–218.
- 34 Harborne A. Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis. Springer Science & Business Media, Dordrecht, 1998.
- 35 Pourmorad F, Hosseinimehr S, Shahabimajd N. Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants. Afr J Biotechnol. 2006; 5: 1142–1145.
- 36 Chinnapongse SL, MacCuspie RI, Hackley VA. Persistence of singly dispersed silver nanoparticles in natural freshwaters, synthetic seawater, and simulated estuarine waters. Sci Total Environ. 2011; 409: 2443–2450.
- 37 Song JY, Kim BS. Rapid biological synthesis of silver nanoparticles using plant leaf extracts. Bioprocess Biosyst Eng. 2009; 32: 79–84.
- 38
Pal D, Dutta S. Evaluation of the antioxidant activity of the roots and rhizomes of Cyperus rotundus L. Indian J Pharm Sci. 2006; 2: 256–258.
10.4103/0250-474X.25731 Google Scholar
- 39 Pal D, Mitra S. A preliminary study on the in vitro antioxidant activity of the stems of Opuntia vulgaris . J Adv Pharm Technol Res. 2010; 2: 268–272.
- 40 Mohammad AG, Samad M. In vitro effect of α-tocopherol, ascorbic acid and lycopene on low density lipoprotein glycation. Iran J Pharm Res. 2007; 4: 265–271.
- 41 Lee A. Evaluation of saccharifying methods for alcoholic fermentation of starchy substrates. PhD thesis, Iowa State University, Ames, 1955.
- 42 Cirillo VP. Mechanism of glucose transport across the yeast cell membrane. J Bacteriol. 1962; 84: 485–491.
- 43 Marklund SL. Human copper-containing superoxide dismutase of high molecular weight. Proc Natl Acad Sci U S A. 1982; 79: 7634–7638.
- 44 Aebi H. Catalase in vitro. Methods Enzymol. 1984; 105: 121–126.
- 45 Caliborne A. Assay of catalase. In: RA Greenward (ed.). Handbook of Oxygen Radical Research. CRC Press, Boca Raton, 1985; 283–284.
- 46 Hodges DM, DeLong JM, Forney CF, Prange RK. Improving the thiobarbituric acid-reactive-substances assay for estimating lipid peroxidation in plant tissues containing anthocyanin and other interfering compounds. Planta. 1999; 207: 604–611.
- 47
Bailes BK. Diabetes mellitus and its chronic complications. AORN J. 2002; 76: 265–282.
10.1016/S0001-2092(06)61065-X Google Scholar
- 48
Alberti KG, Zimmet PF. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet Med. 1998; 15: 539–553.
10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S CAS PubMed Web of Science® Google Scholar
- 49 Amos AF, McCarty DJ, Zimmet P. The rising global burden of diabetes and its complications: Estimates and projections to the year 2010. Diabet Med. 1997; 14 (Suppl): S7–S85.
- 50 Chitturi S, George J. Hepatotoxicity of commonly used drugs: Nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs. Semin Liver Dis. 2002; 22: 169–184.
- 51 Hoofnagle JH, Serrano J, Knoben JE, Navarro VJ. LiverTox: A website on drug-induced liver injury. Hepatology. 2013; 57: 873–874.
- 52 Dehghan-Shahreza F, Beladi-Mousavi SS, Rafieian-Kopaei M. Medicinal plants and diabetic kidney disease: An updated review on the recent findings. Immunopathol Persa. 2016; 2: 1–6.
- 53 Elekofehinti OO. Saponins: Anti-diabetic principles from medicinal plants. A review. Pathophysiology. 2015; 22: 95–103.
- 54 Bnouham M, Benalla W, Bellahcen S et al. Antidiabetic and antihypertensive effect of a polyphenol-rich fraction of Thymelaea hirsuta L. in a model of neonatal streptozotocin-diabetic and N G-nitro-l-arginine methyl ester-hypertensive rats. J Diabetes. 2012; 4: 307–313.
- 55 Ramachandran S, Rajasekaran A. Blood glucose-lowering effect of Tectona grandis flowers in type 2 diabetic rats: A study on identification of active constituents and mechanisms for antidiabetic action. J Diabetes. 2014; 6: 427–437.
- 56 Dikshit P, Shukla K, Tyagi MK, Garg P, Gambir JK, Shukla R. Antidiabetic and antihyperlipidemic effects of the stem of Musa sapientum Linn. in streptozotocin-induced diabetic rats. J Diabetes. 2012; 4: 378–385.
- 57
Bnouham M, Ziyyat A, Mekhfi H, Thari A, Legssyer A. Medicinal plants with potential antidiabetic activity: A review of ten years of herbal medicine research (1990–2000). Int J Diabetes Metab. 2006; 14: 1–25.
10.1159/000497588 Google Scholar
- 58 Xia X, Weng J. Targeting metabolic syndrome: Candidate natural agents. J Diabetes. 2010; 2: 243–249.
- 59 Rai M, Yadav A, Gade A. Silver nanoparticles as a new generation of antimicrobials. Biotechnol Adv. 2009; 27: 76–83.
- 60 Moldovan B, David L, Achim M, Clichici S, Filip GA. A green approach to phytomediated synthesis of silver nanoparticles using Sambucus nigra L. fruits extract and their antioxidant activity. J Mol Liq. 2016; 221: 271–278.
- 61 Firdhouse MJ, Lalitha P. Biogenic silver nanoparticles: Synthesis, characterization and its potential against cancer inducing bacteria. J Mol Liq. 2016; 222: 1041–1050.
- 62 Labulo AH, Adesuji ET, Dedeke OA et al. A dual-purpose silver nanoparticles biosynthesized using aqueous leaf extract of Detarium microcarpum: An under-utilized species. Talanta. 2016; 160: 735–744.
- 63 Kalishwaralal K, Barathmanikanth S, Pandian SRK, Deepak V, Gurunathan S. Silver nano: A trove for retinal therapies. J Control Release. 2010; 145: 76–90.
- 64 Naraginti S, Kumari PL, Das RK, Sivakumar A, Patil SH, Andhalkar VV. Amelioration of excision wounds by topical application of green synthesized, formulated silver and gold nanoparticles in Albino Wistar rats. Mater Sci Eng C. 2016; 62: 293–300.
- 65 Lateef A, Ojo SA, Oladejo SM. Anti-candida, anti-coagulant and thrombolytic activities of biosynthesized silver nanoparticles using cell-free extract of Bacillus safensis LAU 13. Process Biochem. 2016; 51: 1406–1412.
- 66 Mani A, Vasanthi C, Gopal V, Chellathai D. Role of phyto-stabilised silver nanoparticles in suppressing adjuvant induced arthritis in rats. Int Immunopharmacol. 2016; 41: 17–23.
- 67
Sondi I, Salopek SB. Silver nanoparticles as antimicrobial agent: A case study on E. coli as a model for Gram-negative bacteria. J Colloid Interface Sci. 2004; 1: 177–182.
10.1016/j.jcis.2004.02.012 Google Scholar
- 68 Panácek A, Kvítek L, Prucek R et al. Silver colloid nanoparticles: Synthesis, characterization, and their antibacterial activity. J Phys Chem B. 2006; 33: 16248–16253.
- 69 Sathishkumar P, Preethi J, Vijayan R et al. Anti-acne, anti-dandruff and anti-breast cancer efficacy of green synthesised silver nanoparticles using Coriandrum sativum leaf extract. J Photochem Photobiol B Biol. 2016; 163: 69–76.
- 70 Choo WH, Park CH, Jung SE et al. Long-term exposures to low doses of silver nanoparticles enhanced in vitro malignant cell transformation in non-tumorigenic BEAS-2B cells. Toxicol In Vitro. 2016; 37: 41–49.
- 71 Jang SJ, Jun YI, Tettey CO, Kim KM, Shin HM. In-vitro anticancer activity of green synthesized silver nanoparticles on MCF-7 human breast cancer cells. Mater Sci Eng C. 2016; 68: 430–435.
- 72 Kumar B, Smita K, Seqqat R, Benalcazar K, Grijalva M, Cumbal L. In vitro evaluation of silver nanoparticles cytotoxicity on Hepatic cancer (Hep-G2) cell line and their antioxidant activity: Green approach for fabrication and application. J Photochem Photobiol B Biol. 2016; 159: 8–13.
- 73 Prabhu D, Arulvasu C, Babu G, Manikandan R, Srinivasan P. Biologically synthesized green silver nanoparticles from leaf extract of Vitex negundo L. induce growth-inhibitory effect on human colon cancer cell line HCT15. Process Biochem. 2013; 48: 317–324.
- 74
Abd-Elnaby HM, Abo-Elala GM, Abdel-Raouf UM, Hamed MM. Antibacterial and anticancer activity of extracellular synthesized silver nanoparticles from marine Streptomyces rochei MHM13. Egypt J Aquat Res. 2016; 42: 301–312.
10.1016/j.ejar.2016.05.004 Google Scholar
- 75 Ahmed S, Ahmad M, Swami BL, Ikram S. A review on plants extract mediated synthesis of silver nanoparticles for antimicrobial applications: A green expertise. J Adv Res. 2016; 7: 17–28.
- 76 Hotamisligil GS, Spiegelman BM. Tumor necrosis factor α: A key component of the obesity–diabetes link. Diabetes. 1994; 43: 1271–1278.
- 77 American Diabetes Association. Consensus development conference on antipsychotic drugs and obesity and diabetes. Diabetes Care. 2004; 27: 596–601.
- 78 Francis GA, Fayard E, Picard F, Auwerx J. Nuclear receptors and the control of metabolism. Annu Rev Physiol. 2003; 65: 261–311.
- 79 Ramaiah SK. A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters. Food Chem Toxicol. 2007; 45: 1551–1557.
- 80 Johnston DE. Special considerations in interpreting liver function tests. Am Fam Physician. 1999; 59: 2223–2232.
- 81 Adisa R, Fakeye T. Assessment of the knowledge of community pharmacists regarding common phytopharmaceuticals sold in South Western Nigeria. Trop J Pharm Res. 2006; 5: 619–625.
- 82
Oyewo EB, Adetutu A, Adebisi JA, Olorunnisola OS, Adesokan AA. Sub-chronic administration of Febi super bitters triggered inflammatory responses in male Wistar rats. J Med Sci. 2013; 13: 692–699.
10.3923/jms.2013.692.699 Google Scholar
- 83 Pandey M, Rastogi S, Rawat A. Indian traditional Ayurvedic system of medicine and nutritional supplementation. Evid Based Complement Alternat Med. 2013; 2013: 1–12.
- 84 Bessesen A, Smith-Kielland A, Gadeholt G. Morland reduced synthesis of hepatic and plasma proteins in rats during diethyl ether anaesthesia. Acta Pharmacol Toxicol. 1984; 54: 241–246.
- 85 Kakkar R, Kalra J, Mantha SV, Prasad K. Lipid peroxidation and activity of antioxidant enzymes in diabetic rats. Mol Cell Biochem. 1995; 151: 113–119.
- 86 Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes. 1991; 40: 405–412.
- 87 Bagul P, Banerjee S. Application of resveratrol in diabetes: Rationale, strategies and challenges. Curr Mol Med. 2015; 15: 312–330.
- 88 Sivitz WI, Yorek MA. Mitochondrial dysfunction in diabetes: From molecular mechanisms to functional significance and therapeutic opportunities. Antioxid Redox Signal. 2010; 12: 537–577.
- 89 Rahman K. Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging. 2007; 2: 219–236.
- 90 Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010; 4: 118–126.
- 91 Gupta R, Mathur M, Bajaj VK et al. Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. J Diabetes. 2012; 4: 164–171.
- 92 Kaneto H, Kajimoto Y, Miyagawa JI et al. Beneficial effects of antioxidants in diabetes. Diabetes. 1999; 48: 2398–2406.
- 93 Bloomgarden ZT. Antioxidants and diabetes. Diabetes Care. 1997; 20: 670–673.
- 94 Ong JM, Garvey TW, Henry RR, Kern PAS. The expression of TNF by human muscle: Relationship to insulin resistance. J Clin Invest. 1996; 4: 1111–1116.
- 95 Sengottaiyan A, Aravinthan A, Sudhakar C et al. Synthesis and characterization of Solanum nigrum-mediated silver nanoparticles and its protective effect on alloxan-induced diabetic rats. J Nanostructure Chem. 2016; 6: 41–48.
- 96 Alkaladi A, Abdelazim AM, Afifi M. Antidiabetic activity of zinc oxide and silver nanoparticles on streptozotocin-induced diabetic rats. Int J Mol Sci. 2014; 15: 2015–2023.
- 97 Virgen-Ortiz A, Limon-Miranda S, Soto-Covarrubias M, Apolinar-Iribe A, Rodriguez-Leon E, Iniguez-Palomares R. Biocompatible silver nanoparticles synthesized using Rumex hymenosepalus extract decreases fasting glucose levels in diabetic rats. Dig J Nanomater Biostruct. 2015; 10: 927–933.
- 98 Aruna A, Nandhini S, Karthikeyan V, Bose P, Vijayalakshmi K. Comparative anti-diabetic effect of methanolic extract of insulin plant (Costus pictus) leaves and its silver nanoparticle. IAJPR. 2014; 4: 3217–3230.
- 99 Shaheen TI, El-Naggar ME, Hussein JS et al. Antidiabetic assessment: in vivo study of gold and core-shell silver-gold nanoparticles on streptozotocin-induced diabetic rats. Biomed Pharmacother. 2016; 83: 865–875.
- 100
Subramani K, Ahmed W. Nanotechnology and the future of dentistry. In: Emerging Nanotechnologies in Dentistry. William Andrew Publishing, Boston, 2012; 1–14.
10.1016/B978-1-4557-7862-1.00001-8 Google Scholar
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