• Issue

    Journal of Biomedical Materials Research Part A: Volume 109, Issue 11

    2083-2406
    November 2021

COVER IMAGE

Free Access

Cover Image

  • First Published: 04 October 2021
Cover Image Volume 109 Issue 11, 2021

The cover image is based on the Research Article Artificially altered gravity elicits cell homeostasis unbalance in planarian worms, and cerium oxide nanoparticles counteract this effect by Gianni Ciofani et al., https://doi.org/10.1002/jbm.a.37215.

Free Access

Cover Image

  • First Published: 04 October 2021
Cover Image Volume 109 Issue 11, 2021

The cover image is based on the Research Article Injectable Open-porous PLGA Microspheres as Cell Carriers for Cartilage Regeneration by Songsong Zhu et al., https://doi.org/10.1002/jbm.a.37196.

ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 2083-2090
  • First Published: 13 September 2021

RESEARCH ARTICLES

Dendritic cells support a proliferative antigen-specific T-cell response in the presence of poly(lactic-co-glycolic acid)

  • Pages: 2269-2279
  • First Published: 07 May 2021
Dendritic cells support a proliferative antigen-specific T-cell response in the presence of poly(lactic-co-glycolic acid)

PLGA facilitates DCs to induce a proliferative antigen-specific T-cell response to co-delivered antigen in vivo. This is an early precursor to the previously seen PLGA adjuvant effect. This effect is, at least in part, due to the influence of PLGA on DC phenotype and the subsequent antigen presentation ability. In the absence of  CD11c+ DCs, PLGA failed to induce strong antigen-specific T-cell responses indicating that DCs play a crucial role in PLGA's immunostimulatory effect.