Journal of Biomedical Materials Research Part A

Volume 109, Issue 11 pp. 2199-2211

RESEARCH ARTICLE

Effect of a plasma synthesized polypyrrole coverage on polylactic acid/hydroxyapatite scaffolds for bone tissue engineering

María G. Flores-Sánchez,

Corresponding Author

María G. Flores-Sánchez

[email protected]

orcid.org/0000-0003-3424-4428

Faculty of Engineering, Department of Investigation, La Salle University México, México City, Mexico

Correspondence

María G. Flores-Sánchez, Faculty of Engineering, Department of Investigation, La Salle University México, Av. Benjamín Franklin 45, Cuauhtémoc, CP 06140, México City, México.

Email: [email protected]

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Nancy C. Islas-Arteaga,

Nancy C. Islas-Arteaga

Department of Electric Engineering, Universidad Autónoma Metropolitana, México City, Mexico

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Atlántida M. Raya-Rivera,

Atlántida M. Raya-Rivera

Department of Tissue Engineering, Child Hospital of México Federico Gómez, México City, Mexico

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Diego R. Esquiliano-Rendon,

Diego R. Esquiliano-Rendon

Department of Tissue Engineering, Child Hospital of México Federico Gómez, México City, Mexico

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Juan Morales-Corona,

Juan Morales-Corona

Department of Physics, Universidad Autónoma Metropolitana, México City, Mexico

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Omar E. Uribe-Juarez,

Omar E. Uribe-Juarez

Department of Electric Engineering, Universidad Autónoma Metropolitana, México City, Mexico

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Flor I. Vivar-Velázquez,

Flor I. Vivar-Velázquez

Department of Physics, Universidad Autónoma Metropolitana, México City, Mexico

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Greta P. Ortiz-Vázquez,

Greta P. Ortiz-Vázquez

Department of Biomedical Engineering, New Sanatorium Durango, México City, Mexico

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Roberto Olayo,

Roberto Olayo

Department of Physics, Universidad Autónoma Metropolitana, México City, Mexico

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María G. Flores-Sánchez,

Corresponding Author

María G. Flores-Sánchez

[email protected]

orcid.org/0000-0003-3424-4428

Faculty of Engineering, Department of Investigation, La Salle University México, México City, Mexico

Correspondence

María G. Flores-Sánchez, Faculty of Engineering, Department of Investigation, La Salle University México, Av. Benjamín Franklin 45, Cuauhtémoc, CP 06140, México City, México.

Email: [email protected]

Search for more papers by this author

Nancy C. Islas-Arteaga,

Nancy C. Islas-Arteaga

Department of Electric Engineering, Universidad Autónoma Metropolitana, México City, Mexico

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Atlántida M. Raya-Rivera,

Atlántida M. Raya-Rivera

Department of Tissue Engineering, Child Hospital of México Federico Gómez, México City, Mexico

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Diego R. Esquiliano-Rendon,

Diego R. Esquiliano-Rendon

Department of Tissue Engineering, Child Hospital of México Federico Gómez, México City, Mexico

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Juan Morales-Corona,

Juan Morales-Corona

Department of Physics, Universidad Autónoma Metropolitana, México City, Mexico

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Omar E. Uribe-Juarez,

Omar E. Uribe-Juarez

Department of Electric Engineering, Universidad Autónoma Metropolitana, México City, Mexico

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Flor I. Vivar-Velázquez,

Flor I. Vivar-Velázquez

Department of Physics, Universidad Autónoma Metropolitana, México City, Mexico

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Greta P. Ortiz-Vázquez,

Greta P. Ortiz-Vázquez

Department of Biomedical Engineering, New Sanatorium Durango, México City, Mexico

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Roberto Olayo,

Roberto Olayo

Department of Physics, Universidad Autónoma Metropolitana, México City, Mexico

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First published: 26 April 2021

https://doi.org/10.1002/jbm.a.37205

Citations: 5

Funding information: Consejo Nacional de Ciencia y Tecnología, Grant/Award Number: CB16RF_287927; Universidad La Salle México, Grant/Award Number: EC388-IMC 13/18

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Abstract

Composite biomaterials are solids that contain two or more different materials, combining the properties of their components to restore or improve the function of tissues. In this study, we report the generation of electrospun matrices with osteoconductive properties and porosity using the combination of a biodegradable polyester, polylactic acid (PLA), and hydroxyapatite (HA). Additionally, we report the effects of modifying these matrices through plasma polymerization of pyrrole on the growth and osteogenic differentiation of rabbit bone marrow stem cells. Cells were isolated, seeded and cultured on biomaterials for periods between 7 and 28 days. The matrices we obtained were formed by nano and microfibers containing up to 35.7 wt% HA, presenting a variety of apparent pore sizes to allow for the passage of nutrients to bone cells. Scanning electron microscopy showed that the fibers were coated with polypyrrole doped with iodine, and MTT assay demonstrated this increased cell proliferation and significantly improved cell viability due to the adhesive properties of the polymer. Our results show that PLA/HA/Pyrrole/Iodine matrices are favorable for bone tissue engineering.

CONFLICT OF INTEREST

We have no competing interest.

Open Research

DATA AVAILABILITY STATEMENT

All data generated or analysed during this study are included in this published article or are available from the corresponding author on reasonable request.

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Volume109, Issue11

November 2021

Pages 2199-2211

Effect of a plasma synthesized polypyrrole coverage on polylactic acid/hydroxyapatite scaffolds for bone tissue engineering

Abstract

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

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Effect of a plasma synthesized polypyrrole coverage on polylactic acid/hydroxyapatite scaffolds for bone tissue engineering

Abstract

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

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