• Issue

    Hepatology: Volume 64, Issue 5

    1395-1827
    November 2016
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Issue Information

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Masthead

  • First Published: 21 October 2016
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Table of contents

  • First Published: 21 October 2016

Hepatology Highlights

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Hepatology Highlights

Jean-François Dufour, 
  • Pages: 1395-1397
  • First Published: 21 October 2016

Comments from the Editors

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Modeling fatty liver disease in animals: Is there an optimal approach, and is the effort worthwhile?

Jacquelyn J. Maher M.D., 
  • Pages: 1398-1400
  • First Published: 17 September 2016

Editorials

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Emerging complexities with hepatitis C virus direct-acting antiviral regimens: Less is still Way more

Lucas A. Hill Pharm.D.,  David L. Wyles M.D., 
  • Pages: 1401-1403
  • First Published: 16 September 2016
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The end of the hepatitis C burden: Really?

Jean-Michel Pawlotsky M.D., Ph.D., 
  • Pages: 1404-1407
  • First Published: 03 August 2016
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Bringing to an end mother-to-child transmission of hepatitis B: A role for quantitative hepatitis B surface antigen?

Geoffrey Dusheiko M.B. B.Ch., F.C.P.(S.A.), F.R.C.P.,  Philippa Easterbrook M.D., 
  • Pages: 1408-1410
  • First Published: 25 July 2016
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The many faces of RIPK3: What about NASH?

Lily Dara M.D.,  Neil Kaplowitz M.D., 
  • Pages: 1411-1413
  • First Published: 24 June 2016
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Regulation of retinol-binding protein 4 and retinol metabolism in fatty liver disease

Stefano Romeo M.D., Ph.D.,  Luca Valenti M.D., 
  • Pages: 1414-1416
  • First Published: 11 July 2016
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Nonalcoholic fatty liver disease and metabolic syndrome: Shared genetic basis of pathogenesis

Silvia Sookoian M.D., Ph.D.,  Carlos J. Pirola Ph.D., F.A.H.A., 
  • Pages: 1417-1420
  • First Published: 02 August 2016
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An infernal cross-talk between oncogenic β-catenin and c-Met in hepatocellular carcinoma: Evidence from mouse modeling

Rosa M. Pascale M.D.,  Francesco Feo M.D.,  Diego F. Calvisi M.D., 
  • Pages: 1421-1423
  • First Published: 06 September 2016
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miRs*: Innocent bystanders only?

Silvia Giordano M.D., Ph.D., 
  • Pages: 1424-1426
  • First Published: 02 August 2016
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MET and epidermal growth factor signaling: The pillars of liver regeneration?

Jeffrey H. Albrecht M.D., 
  • Pages: 1427-1429
  • First Published: 15 September 2016

Rapid Communication

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Assessment of the clinical cardiac drug-drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys

Christopher P. Regan,  Pierre Morissette,  Hillary K. Regan,  Jeffery J. Travis,  Pamela Gerenser,  Jianzhong Wen,  Kevin Fitzgerald,  Shaun Gruver,  Joseph J. DeGeorge,  Frederick J. Sannajust, 
  • Pages: 1430-1441
  • First Published: 30 July 2016

Viral Hepatitis

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Hepatitis C Disease Burden in the United States in the era of oral direct-acting antivirals

Jagpreet Chhatwal,  Xiaojie Wang,  Turgay Ayer,  Mina Kabiri,  Raymond T. Chung,  Chin Hur,  Julie M. Donohue,  Mark S. Roberts,  Fasiha Kanwal, 
  • Pages: 1442-1450
  • First Published: 25 March 2016
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Quantitative maternal hepatitis B surface antigen predicts maternally transmitted hepatitis B virus infection

Wan-Hsin Wen,  Chi-Wen Huang,  Wei-Chu Chie,  Chun-Yan Yeung,  Lu-Lu Zhao,  Wen-Terng Lin,  Jia-Feng Wu,  Yen-Hsuan Ni,  Hong-Yuan Hsu,  Mei-Hwei Chang,  Lung-Huang Lin,  Huey-Ling Chen, 
  • Pages: 1451-1461
  • First Published: 04 April 2016
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A new 3p25 locus is associated with liver fibrosis progression in human immunodeficiency virus/hepatitis C virus-coinfected patients

Damien Ulveling,  Sigrid Le Clerc,  Aurélie Cobat,  Taoufik Labib,  Josselin Noirel,  Vincent Laville,  Cédric Coulonges,  Wassila Carpentier,  Bertrand Nalpas,  Markus H. Heim,  Thierry Poynard,  Andreas Cerny,  Stanislas Pol,  Pierre-Yves Bochud,  François Dabis,  Ioannis Theodorou,  Yves Lévy,  Dominique Salmon,  Laurent Abel,  Stéphanie Dominguez,  Jean-François Zagury,  the HEPAVIH ANRS CO13 Cohort Study Group ,  the Swiss Hepatitis C Cohort Study Group ,  the French ANRS HC EP 26 Genoscan Study Group , 
  • Pages: 1462-1472
  • First Published: 23 June 2016
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Prospective study of guideline-tailored therapy with direct-acting antivirals for hepatitis C virus-associated mixed cryoglobulinemia

Laura Gragnani,  Marcella Visentini,  Elisa Fognani,  Teresa Urraro,  Adriano De Santis,  Luisa Petraccia,  Marie Perez,  Giorgia Ceccotti,  Stefania Colantuono,  Milica Mitrevski,  Cristina Stasi,  Martina Del Padre,  Monica Monti,  Elena Gianni,  Alessandro Pulsoni,  Massimo Fiorilli,  Milvia Casato,  Anna Linda Zignego, 
  • Pages: 1473-1482
  • First Published: 02 August 2016
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First international external quality assessment for hepatitis delta virus RNA quantification in plasma

Frédéric Le Gal,  Ségolène Brichler,  Roland Sahli,  Sylvie Chevret,  Emmanuel Gordien, 
  • Pages: 1483-1494
  • First Published: 17 August 2016
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Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin

Rajiv G. Tawar,  Laura Heydmann,  Charlotte Bach,  Jörg Schüttrumpf,  Shailesh Chavan,  Barnabas J. King,  C. Patrick McClure,  Jonathan K. Ball,  Patrick Pessaux,  François Habersetzer,  Ralf Bartenschlager,  Mirjam B. Zeisel,  Thomas F. Baumert, 
  • Pages: 1495-1506
  • First Published: 17 August 2016
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Metabolic syndrome increases cardiovascular events but not hepatic events and death in patients with chronic hepatitis B

Jenny Yeuk-Ki Cheng,  Vincent Wai-Sun Wong,  Yee-Kit Tse,  Angel Mei-Ling Chim,  Henry Lik-Yuen Chan,  Grace Lai-Hung Wong, 
  • Pages: 1507-1517
  • First Published: 29 September 2016

Steatohepatitis/Metabolic Liver Disease

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Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury

Sanjoy Roychowdhury,  Rebecca L. McCullough,  Carlos Sanz-Garcia,  Paramananda Saikia,  Naim Alkhouri,  Ammar Matloob,  Katherine A. Pollard,  Megan R. McMullen,  Colleen M. Croniger,  Laura E. Nagy, 
  • Pages: 1518-1533
  • First Published: 15 June 2016
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Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice

Seung-Ah Lee,  Jason J. Yuen,  Hongfeng Jiang,  Barbara B. Kahn,  William S. Blaner, 
  • Pages: 1534-1546
  • First Published: 26 May 2016
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Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study

Jeffrey Cui,  Chi-Hua Chen,  Min-Tzu Lo,  Nicholas Schork,  Ricki Bettencourt,  Monica P. Gonzalez,  Archana Bhatt,  Jonathan Hooker,  Katherine Shaffer,  Karen E. Nelson,  Michelle T. Long,  David A. Brenner,  Claude B. Sirlin,  Rohit Loomba,  for the Genetics of NAFLD in Twins Consortium, 
  • Pages: 1547-1558
  • First Published: 17 June 2016
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Nogo-B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate–activated protein kinase alpha–dependent pathway

Wenquan Hu,  Wenwen Zhang,  Yuanli Chen,  Ujala Rana,  Ru-jeng Teng,  Yajun Duan,  Zhong Liu,  Baofeng Zhao,  Jamie Foeckler,  Hartmut Weiler,  Rachel E. Kallinger,  Michael J. Thomas,  Kezhong Zhang,  Jihong Han,  Qing Robert Miao, 
  • Pages: 1559-1576
  • First Published: 02 August 2016
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The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

Zobair M. Younossi,  Deirdre Blissett,  Robert Blissett,  Linda Henry,  Maria Stepanova,  Youssef Younossi,  Andrei Racila,  Sharon Hunt,  Rachel Beckerman, 
  • Pages: 1577-1586
  • First Published: 20 August 2016

Hepatobiliary Malignancies

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Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant β-catenin

Junyan Tao,  Emily Xu,  Yifei Zhao,  Sucha Singh,  Xiaolei Li,  Gabrielle Couchy,  Xin Chen,  Jessica Zucman-Rossi,  Maria Chikina,  Satdarshan P.S. Monga, 
  • Pages: 1587-1605
  • First Published: 20 April 2016
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N-myc downstream-regulated gene 2 inhibits human cholangiocarcinoma progression and is regulated by leukemia inhibitory factor/MicroRNA-181c negative feedback pathway

Jiabei Wang,  Changming Xie,  Shangha Pan,  Yingjian Liang,  Jihua Han,  Yaliang Lan,  Jing Sun,  Keyu Li,  Boshi Sun,  Guangchao Yang,  Huawen Shi,  Yuejin Li,  Ruipeng Song,  Xirui Liu,  Mingxi Zhu,  Dalong Yin,  Huanlai Wang,  Xuan Song,  Zhaoyang Lu,  Hongchi Jiang,  Tongsen Zheng,  Lianxin Liu, 
  • Pages: 1606-1622
  • First Published: 17 August 2016
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The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry

Alina Simerzin,  Elina Zorde-Khvalevsky,  Mila Rivkin,  Revital Adar,  Jessica Zucman-Rossi,  Gabrielle Couchy,  Tania Roskams,  Olivier Govaere,  Moshe Oren,  Hilla Giladi,  Eithan Galun, 
  • Pages: 1623-1636
  • First Published: 15 June 2016
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Angiopoietin-like protein 1 antagonizes MET receptor activity to repress sorafenib resistance and cancer stemness in hepatocellular carcinoma

Hsin-An Chen,  Tsang-Chih Kuo,  Chi-Feng Tseng,  Jui-Ti Ma,  Shu-Ting Yang,  Chia-Jui Yen,  Ching-Yao Yang,  Shian-Ying Sung,  Jen-Liang Su, 
  • Pages: 1637-1651
  • First Published: 17 August 2016

Autoimmune, Cholestatic and Biliary Disease

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Wnt signaling regulates hepatobiliary repair following cholestatic liver injury in mice

Hirohisa Okabe,  Jing Yang,  Kyle Sylakowski,  Mladen Yovchev,  Yoshitaka Miyagawa,  Shanmugam Nagarajan,  Maria Chikina,  Michael Thompson,  Michael Oertel,  Hideo Baba,  Satdarshan P Monga,  Kari Nichole Nejak-Bowen, 
  • Pages: 1652-1666
  • First Published: 17 August 2016

Liver Injury/Regeneration

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Chemokine (C-C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury

Jana C. Mossanen,  Oliver Krenkel,  Can Ergen,  Olivier Govaere,  Anke Liepelt,  Tobias Puengel,  Felix Heymann,  Sandra Kalthoff,  Eric Lefebvre,  Dirk Eulberg,  Tom Luedde,  Gernot Marx,  Christian P. Strassburg,  Tania Roskams,  Christian Trautwein,  Frank Tacke, 
  • Pages: 1667-1682
  • First Published: 15 June 2016
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The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury

Shi Yue,  Jianjun Zhu,  Ming Zhang,  Changyong Li,  Xingliang Zhou,  Min Zhou,  Michael Ke,  Ronald W. Busuttil,  Qi-Long Ying,  Jerzy W. Kupiec-Weglinski,  Qiang Xia,  Bibo Ke, 
  • Pages: 1683-1698
  • First Published: 30 July 2016
Open Access

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice

Peter Lundbäck,  Jonathan D. Lea,  Agnieszka Sowinska,  Lars Ottosson,  Camilla Melin Fürst,  Johanna Steen,  Cecilia Aulin,  Joanna I. Clarke,  Anja Kipar,  Lena Klevenvall,  Huan Yang,  Karin Palmblad,  B. Kevin Park,  Kevin J. Tracey,  Anna M. Blom,  Ulf Andersson,  Daniel J. Antoine,  Helena Erlandsson Harris, 
  • Pages: 1699-1710
  • First Published: 30 July 2016
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Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation

Shirish Paranjpe,  William C. Bowen,  Wendy M. Mars,  Anne Orr,  Meagan M. Haynes,  Marie C. DeFrances,  Silvia Liu,  George C. Tseng,  Anastasia Tsagianni,  George K. Michalopoulos, 
  • Pages: 1711-1724
  • First Published: 11 July 2016

Liver Biology/Pathobiology

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Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling

Bo Ma,  Sarah E. Wheeler,  Amanda M. Clark,  Diana L. Whaley,  Min Yang,  Alan Wells, 
  • Pages: 1725-1742
  • First Published: 02 August 2016
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Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

Volker M. Lauschke,  Sabine U. Vorrink,  Sabrina M.L. Moro,  Fatemah Rezayee,  Åsa Nordling,  Delilah F.G. Hendriks,  Catherine C. Bell,  Rowena Sison-Young,  B. Kevin Park,  Christopher E. Goldring,  Ewa Ellis,  Inger Johansson,  Souren Mkrtchian,  Tommy B. Andersson,  Magnus Ingelman-Sundberg, 
  • Pages: 1743-1756
  • First Published: 17 August 2016
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Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ

Jing Yi,  Li Lu,  Kilangsungla Yanger,  Wenqi Wang,  Bo Hwa Sohn,  Ben Z. Stanger,  Min Zhang,  James F. Martin,  Jaffer A. Ajani,  Junjie Chen,  Ju-Seog Lee,  Shumei Song,  Randy L. Johnson, 
  • Pages: 1757-1772
  • First Published: 17 August 2016

Liver Capsule

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Liver Capsule: FXR agonists against liver disease

Claudia D. Fuchs,  Peter Schwabl,  Thomas Reiberger,  Michael Trauner, 
  • Page: 1773
  • First Published: 16 September 2016

Review

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Platelets: No longer bystanders in liver disease

Abhishek Chauhan,  David H. Adams,  Steve P. Watson,  Patricia F. Lalor, 
  • Pages: 1774-1784
  • First Published: 02 March 2016

Concise Review

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The case for immune-based approaches in biliary tract carcinoma

Austin G. Duffy,  Oxana V. Makarova-Rusher,  Tim F. Greten, 
  • Pages: 1785-1791
  • First Published: 14 May 2016

Hepatology Elsewhere

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Evolving insights in the pathophysiology of complications of cirrhosis: The farnesoid X receptor (FXR) to the rescue?

Wim Laleman M.D., Ph.D,  Jonel Trebicka M.D., Ph.D,  Len Verbeke M.D., Ph.D, 
  • Pages: 1792-1794
  • First Published: 17 August 2016
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Hepatocellular carcinoma in nonalcoholic fatty liver disease: A link between oxidative stress and T-cell suppression

Muhammad Asif Qureshi,  Yong Ook Kim,  Detlef Schuppan M.D., Ph.D., 
  • Pages: 1794-1797
  • First Published: 15 September 2016
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Mitochondrial MIsCUes in liver regeneration

Mateus T. Guerra Ph.D., 
  • Pages: 1797-1799
  • First Published: 15 September 2016

Clinical Observations in Hepatology

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Combined hepatocellular-cholangiocarcinoma in a patient with Abernethy malformation and tetralogy of Fallot: A case report

Sofie Happaerts,  Amélie Foucault,  Jean Sébastien Billiard,  Bich Nguyen,  Franck Vandenbroucke-Menu, 
  • Pages: 1800-1802
  • First Published: 26 May 2016
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Detection of hepatitis b virus DNA in the blood of a stem cell donor after granulocyte colony-stimulating factor treatment

Michael Punzel,  Patrick Medd,  Hannah Hunter,  Richard Cunningham,  Bryson Pottinger,  Bernd Burde,  Marek Widera,  Annegret Quade,  Gerhard Ehninger,  Anna Kozlova,  Helmuth Schmidt,  Karin Buhrmann,  Christian G. Schüttler,  Dieter Glebe,  Annelies Billen,  Alexander H. Schmidt,  Thilo Mengling,  Jens Verheyen, 
  • Pages: 1803-1805
  • First Published: 30 May 2016

Correspondence

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Propranolol use beyond 6 months increases mortality in patients with Child-Pugh C cirrhosis and ascites

Georgios N. Kalambokis M.D.,  Dimitrios Christodoulou M.D.,  Gerasimos Baltayiannis M.D.,  Leonidas Christou M.D., 
  • Pages: 1806-1808
  • First Published: 26 March 2016
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Reply

Lars Bossen B.S.,  Aleksander Krag M.D., Ph.D.,  Hendrik Vilstrup M.D., D.Sc.,  Hugh Watson Ph.D.,  Peter Jepsen M.D., Ph.D., 
  • Page: 1808
  • First Published: 26 March 2016
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Successful antiviral treatment of chronic hepatitis C leads to a rapid decline of liver stiffness without an early effect on spleen stiffness

Wim Verlinden M.D.,  Sven Francque M.D., Ph.D.,  Peter Michielsen M.D., Ph.D.,  Thomas Vanwolleghem M.D., Ph.D., 
  • Pages: 1809-1810
  • First Published: 26 April 2016
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Reply

Guadalupe Garcia-Tsao M.D.,  Jordan Sack M.D., 
  • Pages: 1810-1811
  • First Published: 26 April 2016
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Comment on: Acute and chronic hepatitis E virus infection in human immunodeficiency virus-infected U.S. women

Lisa A Spacek M.D., Ph.D.,  Steven F. Solga M.D., 
  • Pages: 1811-1812
  • First Published: 28 March 2016
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Reply

Mark H. Kuniholm Ph.D.,  Kenrad E. Nelson M.D., 
  • Pages: 1812-1813
  • First Published: 28 March 2016
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Hepatitis C virus and lymphoma

Antonio Ponzetto M.D.,  Guido Carloni M.D., 
  • Page: 1813
  • First Published: 28 March 2016
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Reply

Tung-Hung Su M.D., Ph.D.,  Chi-Ling Chen Ph.D.,  Jia-Horng Kao M.D., Ph.D., F.A.A.S.L.D., 
  • Page: 1814
  • First Published: 28 March 2016
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Addendum: hypercaloric diets with high meal frequency, but not increased meal size, increase intrahepatic triglycerides: A randomized controlled trial

Mireille J. Serlie M.D., Ph.D.,  Kasper W. ter Horst M.D.,  Andrew W. Brown Ph.D., 
  • Pages: 1814-1816
  • First Published: 31 March 2016
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Endoscopic therapy plus beta blocker is still the first choice for prevention of variceal rebleeding?

Gin-Ho Lo M.D., 
  • Pages: 1816-1817
  • First Published: 30 May 2016
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Reply

I. Lisanne Holster M.D., Ph.D.,  Eric T.T.L. Tjwa M.D., Ph.D.,  Adriaan Moelker M.D., Ph.D.,  Ernst J. Kuipers M.D., Ph.D.,  Henk R. van Buuren M.D., Ph.D., 
  • Pages: 1817-1818
  • First Published: 30 May 2016
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Changes in patient backgrounds may increase the incidence of HCC after SVR in the era of IFN-free therapy for HCV

Hidenori Toyoda M.D., Ph.D.,  Takashi Kumada M.D., Ph.D.,  Toshifumi Tada M.D., 
  • Pages: 1818-1819
  • First Published: 02 May 2016
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Clinical outcomes after coronary angiography in nonalcoholic fatty liver disease

Savas Sarikaya M.D.,  Yasar Turan M.D.,  Mehmet Celikbilek M.D., 
  • Pages: 1819-1820
  • First Published: 26 April 2016
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Reply

Vincent Wai-Sun Wong M.D.,  Grace Lai-Hung Wong M.D.,  Henry Lik-Yuen Chan M.D., 
  • Pages: 1820-1821
  • First Published: 08 April 2016
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Hepatitis C management in prisons: An insight into daily clinical practice in three major Italian correctional houses

Antonella Foschi M.D.,  Maddalena Casana M.D.,  Anna Radice M.D.,  Roberto Ranieri M.D.,  Antonella d'Arminio Monforte M.D., Ph.D., 
  • Pages: 1821-1822
  • First Published: 26 April 2016
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Reply

Natasha K. Martin D.Phil.,  Peter Vickerman D.Phil.,  Matthew Hickman Ph.D., 
  • Pages: 1822-1823
  • First Published: 26 April 2016
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Prevention of mother-to-child transmission of hepatitis B virus by treating mothers with high viral loads

Yi-Hua Zhou M.D., Ph.D., 
  • Pages: 1823-1824
  • First Published: 26 April 2016
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Reply

Robert S. Brown Jr. M.D., M.P.H.,  Brian J. McMahon M.D.,  Anna S.F. Lok M.D.,  John B. Wong M.D.,  Ahmed T. Ahmed M.B.B.Ch.,  Mohamad A. Mouchli M.D.,  Zhen Wang Ph.D.,  Larry J. Prokop M.L.S.,  Mohammad Hassan Murad M.D., M.P.H.,  Khaled Mohammed M.B.B.Ch., M.P.H., 
  • Pages: 1824-1825
  • First Published: 26 April 2016
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Treating hepatitis B virus/hepatitis C virus coinfected patients with direct-acting hepatitis C virus antivirals only is not safe

Resat Ozaras M.D.,  Mustafa Sunbul M.D.,  Mehmet Parlak M.D.,  Hurrem Bodur M.D.,  Hakan Leblebicioglu M.D., 
  • Pages: 1825-1827
  • First Published: 04 April 2016

Issue Information

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Notices

  • First Published: 21 October 2016
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Instructions for authors

  • First Published: 21 October 2016
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Information for readers

  • First Published: 21 October 2016