European Journal of Immunology: Vol 41, No 5

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European Journal of Immunology: Volume 41, Issue 5

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Cover Picture

Cover Picture: Eur. J. Immunol. 5/11

Editorial Board

Editorial Board: Eur. J. Immunol. 5/11

Contents

Contents – Eur. J. Immunol. 5/11

In this issue

In this issue

News and EFIS

Medical societies unite to support research in Europe

Meet EFIS at EULAR 2011!

Obituary

Professor Jürg Tschopp (1951–2011)

Novartis Immunology Prizes

2010 Novartis Immunology Prizes

Highlights

Reviews

Memory T cells as an occupying force

Mitochondria: Sovereign of inflammation?†

A clinical perspective of IL-1β as the gatekeeper of inflammation

Commentary

Setting the threshold for extra-thymic differentiation of Foxp3+ Tregs: TGF-β-dependent and T-cell autonomous

Frontline

Role of CLIC4 in the host innate responses to bacterial lipopolysaccharide

Correction(s) for this article

Correction: Role of CLIC4 in the host innate responses to bacterial lipopolysaccharide

Altered purinergic signaling in CD73-deficient mice inhibits tumor progression

Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells

Sub-optimal CD4+ T-cell activation triggers autonomous TGF-β-dependent conversion to Foxp3+ regulatory T cells

Cellular immune response

Research Article

Chemokine receptor CX3CR1 promotes dendritic cell development under steady-state conditions

IKK-β-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury

Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t

T-cell synapse formation depends on antigen recognition but not CD3 interaction: Studies with TCR:ζ, a candidate transgene for TCR gene therapy

CD38 identifies a hypo-proliferative IL-13-secreting CD4+ T-cell subset that does not fit into existing naive and memory phenotype paradigms

Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus

Secondary CD8+ T-cell responses are controlled by systemic inflammation

Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs

In vivo diabetogenic action of CD4+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18

Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice

Immunity to infection

Research Article

A critical role for phagocytosis in resistance to malaria in iron-deficient mice

Correction(s) for this article

Correction: A critical role for phagocytosis in resistance to malaria in iron-deficient mice

Leishmania donovani glycosphingolipid facilitates antigen presentation by inducing relocation of CD1d into lipid rafts in infected macrophages

c-Rel promotes type 1 and type 17 immune responses during Leishmania major infection

Immunomodulation

Research Article

TLR2 signaling improves immunoregulation to prevent type 1 diabetes

Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development

Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells

Innate immunity

Research Article

C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin-1

Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands

Molecular immunology

Research Article

Translocation of an antibody transgene requires AID and occurs by interchromosomal switching to all switch regions except the mu switch region

TCR-like antibodies distinguish conformational and functional differences in two- versus four-domain auto reactive MHC class II–peptide complexes

Clinical immunology

Research Article

Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62LloFoxP3+CD4+ T cells with limited suppressor activity

Short Communication

Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg

Technical comment

The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responses

Corrections

Correction: Intrathecal immune responses to EBV in early MS

This article corrects the following:

Intrathecal immune responses to EBV in early MS

Correction: Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells

This article corrects the following:

Mitochondria: Sovereign of inflammation?^†

Setting the threshold for extra-thymic differentiation of Foxp3⁺ Tregs: TGF-β-dependent and T-cell autonomous

Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3⁺ regulatory T cells

Sub-optimal CD4⁺ T-cell activation triggers autonomous TGF-β-dependent conversion to Foxp3⁺ regulatory T cells

CD38 identifies a hypo-proliferative IL-13-secreting CD4⁺ T-cell subset that does not fit into existing naive and memory phenotype paradigms

Secondary CD8⁺ T-cell responses are controlled by systemic inflammation

In vivo diabetogenic action of CD4⁺ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18

Increased apoptosis, curtailed expansion and incomplete differentiation of CD8⁺ T cells combine to decrease clearance of L. monocytogenes in old mice

Steady state migratory RelB⁺ langerin⁺ dermal dendritic cells mediate peripheral induction of antigen-specific CD4⁺CD25⁺Foxp3⁺ regulatory T cells

Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62L^loFoxP3⁺CD4⁺ T cells with limited suppressor activity

Correction: Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4⁺ T cells

Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4⁺ T cells

Correction: Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4⁺ memory T lymphocyte populations

Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4⁺ memory T lymphocyte populations