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ARTICLE
Open Access

oa

PRC2-mediated apoptosis evasion is a therapeutic target of MDS/AML harboring inv(3)/t(3;3) and monosomy 7
Hiroyoshi Kunimoto, Ayaka Miura, Maiko Sagisaka, Mieko Ito, Ryoichi Maenosono, Hirofumi Yamauchi, Kazuki Nishimura, Daisuke Honma, Shinji Tsutsumi, Akiko Adachi, Takayuki Sakuma, Takuma Ohashi, Hiroshi Teranaka, Junji Ikeda, Sei Samukawa, Takashi Toya, Yuka Harada, Noriko Doki, Sheng F. Cai, Hiroaki Maki, Hiroaki Goto, Akihide Yoshimi, Hideaki Nakajima,

First published: 13 July 2025

Graphical Abstract
ARTICLE
Open Access

oa

Expanding the phenotypic and genetic landscape of congenital neutropenia through whole-exome and genome sequencing
Séverine Marti, Philippe Pellet, Blandine Beaupain, Léa Durix, Julien Buratti, Yves Réguerre, Nathalie Aladjidi, Saba Azarnoush, Severine Clauin, Wahid Abou Chahla, Gilles Blaison, Jeremy Bertand, Damien Bodet, Benoit Brethon, Jessica Chane-Teng, Manon Delafoy, Chrystelle Dupraz, Virginie Gandemer, Philippe Denizeau, Alice Goldenberg, Pierre Hirsch, Anaïs l'Haridon, Aude Marie-Cardine, Gabriella Vera, Brigitte Nelken, Laure Nizery, Marie Nolla, Marlène Pasquet, Jérémie Rosain, Louis Terriou, Isabelle Plo, Jean Donadieu, Christine Bellanné-Chantelot,

First published: 11 June 2025

Graphical Abstract
LETTER
Open Access

oa

Development of myeloid neoplasia associated with prolonged immune cell-associated hematotoxicity after CAR T-cell treatment of B-cell lymphoma: Should we surveille for pre-existing myeloid mutations?
Mattias Carlsten, Elisa Linnea Lindfors Rossi, Martin Jädersten, Bianca Tesi, Sulaf Abd Own, Brigitta Sander, Stefan Deneberg, Anne Ivinskiy, Kristina Sonnevi, Hanna Sjölund, Gunilla Enblad, Björn Wahlin, Stephan Mielke,

First published: 05 June 2025
REVIEW ARTICLE
Open Access

oa

Applications of machine learning for immunophenotypic measurable residual disease assessment in acute myeloid leukemia
Tim R. Mocking, Arjan A. van de Loosdrecht, Jacqueline Cloos, Costa Bachas,

First published: 21 May 2025

Collections: Reviews
REVIEW ARTICLE
Open Access

oa

Metabolism in hematology: Technological advances open new perspectives on disease biology and treatment
Eileen Haring, Joerg M. Buescher, Petya Apostolova,

First published: 19 May 2025

Collections: Reviews
LETTER
Open Access

oa

Event-free survival in early polycythemia vera patients correlates with molecular response to ropeginterferon alfa-2b or hydroxyurea/best available therapy (PROUD-PV/CONTINUATION-PV)
Jean-Jacques Kiladjian, Christoph Klade, Pencho Georgiev, Dorota Krochmalczyk, Liana Gercheva-Kyuchukova, Miklos Egyed, Petr Dulicek, Arpad Illes, Halyna Pylypenko, Lylia Sivcheva, Jiří Mayer, Vera Yablokova, Kurt Krejcy, Victoria Empson, Hans C. Hasselbalch, Robert Kralovics, Heinz Gisslinger, for the PROUD-PV Study Group,

First published: 03 May 2025
ARTICLE
Open Access

oa

Comparing functional and genomic-based precision medicine in blood cancer patients
Lukas Kazianka, Alexander Pichler, Christiane Agreiter, Johannes Rohrbeck, Christoph Kornauth, Edit Porpaczy, Christian Sillaber, Wolfgang R. Sperr, Karoline V. Gleixner, Alexander Hauswirth, Ulrich Jäger, Peter Valent, Constanze Jonak, Stefanie Porkert, Ruth Exner, Wolfgang Willenbacher, Dominik Wolf, Peter Neumeister, Katharina Prochazka, Alexander Deutsch, Richard Greil, Clemens Schmitt, Robin Ristl, Marius Mayerhoefer, Ingrid Simonitsch-Klupp, Tea Pemovska, Philipp B. Staber,

First published: 24 April 2025

Graphical Abstract
PERSPECTIVE
Open Access

oa

Implementation science in hemato-oncology molecular diagnostics in France via the Groupe des Biologistes Moléculaire des Hémopathies Malignes (GBMHM)
Jean-Michel Cayuela, Pierre Sujobert, Pascale Flandrin-Gresta, Anne-Sophie Alary, Carole Maute, Damien Luque-Paz, Cédric Pastoret, Stéphanie Dulucq, Audrey Gauthier, Meryl Darlington, Isabelle Durand-Zaleski, Olivier Kosmider, Elizabeth Macintyre,

First published: 08 April 2025
ARTICLE
Open Access

oa

Two distinct fetal-type signatures characterize juvenile myelomonocytic leukemia
Marion Strullu, Chloé Arfeuille, Aurélie Caye-Eude, Loïc Maillard, Elodie Lainey, Florian Piques, Bruno Cassinat, Fabien Guimiot, Jean-Hugues Dalle, André Baruchel, Christine Chomienne, Dominique Bonnet, Michèle Souyri, Hélène Cavé,

First published: 25 March 2025

Collections: Pediatric Hematology

Graphical Abstract
REVIEW ARTICLE
Open Access

oa

Low-risk MDS—A spotlight on precision medicine for SF3B1-mutated patients
Shoshana Burke, Onima Chowdhury, Kevin Rouault-Pierre,

First published: 21 March 2025

Collections: Reviews
ARTICLE
Open Access

oa

Cell-free DNA for detection and monitoring of extramedullary AML relapse
Henri C. Hupe, Clara P. Wienecke, Stephan Bartels, Elisa Schipper, Jannika Leßmann, Alina Lasch, Maximilian Bader, Razif Gabdoulline, Martin Neugebohren, Elke Dammann, Hans H. Kreipe, Ulrich Lehmann, Anke K. Bergmann, Nataliya Di Donato, Michael Stadler, Matthias Eder, Arnold Ganser, Florian H. Heidel, Felicitas Thol, Michael Heuser,

First published: 10 March 2025

Graphical Abstract
LETTER
Open Access

oa

Validation of the diagnostic potential of 17 immunophenotypic core markers defined by the ELN-iMDS-Flow Working Group in an independent cohort of patients with MDS
Coen R. Veenstra, Canan Alhan, Theresia M. Westers, Arjan A. van de Loosdrecht,

First published: 07 March 2025
ARTICLE
Open Access

oa

HLA evolutionary divergence score after donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation
Sophie Le Grand, Juliette Villemonteix, Etienne Daguindau, Marylise Fort, Sophie Caillat-Zucman, Vincent Allain, Anne Dormoy, Veronique De Mas, Eric Delabesse, Christian Recher, Regis Peffault de Latour, Nicolas Vallet, David Michonneau, Sarah Guenounou, Anne Huynh,

First published: 13 February 2025

Graphical Abstract
LETTER
Open Access

oa

Cytopenic overt primary myelofibrosis at presentation: Analysis of outcomes in the prospective, real-world ERNEST-2 registry
Paola Guglielmelli, Arianna Ghirardi, Alessandra Carobbio, Arianna Masciulli, Lucrezia Morrone, Barbara Mora, Elisa Rumi, Ana Triguero, Maria C. Finazzi, Helna Pettersson, Valentina Boldrini, Daniele Vanni, Alessandro Rambaldi, Francesco Passamonti, Alberto Alvarez-Larràn, Bjorn Andreasson, Alessandro M. Vannucchi, Tiziano Barbui,

First published: 31 January 2025
REVIEW ARTICLE
Open Access

oa

Diagnosis and treatment of AML in the context of WHO and ICC 2022 classifications: Divergent nomenclature converges on common therapies
Uwe Platzbecker, Richard A. Larson, Sandeep Gurbuxani,

First published: 31 January 2025

Collections: Reviews
ARTICLE
Open Access

oa

Disease characteristics and outcomes of acute myeloid leukemia in germline RUNX1 deficiency (Familial Platelet Disorder with associated Myeloid Malignancy)
Martijn P. T. Ernst, Jurjen Versluis, Peter J. M. Valk, Marc Bierings, Rienk Y. J. Tamminga, Louise H. Hooimeijer, Konstanze Döhner, Paolo Gresele, Kiran Tawana, Saskia M. C. Langemeijer, Bert A. Van der Reijden, Helena Podgornik, Matjaz Sever, Tor H. A. Tvedt, Tom Vulliamy, Jude Fitzgibbon, Inderjeet Dokal, Panagiotis Baliakas, José M. Bastida, Christian Pohlkamp, Torsten Haferlach, Lise Larcher, Jean Soulier, Roger E. G. Schutgens, Kathleen Freson, Nicolas Duployez, Bob Löwenberg, Katrin Ericson, Jörg Cammenga, Tim Ripperger, Marc H. G. P. Raaijmakers,

First published: 16 January 2025

Graphical Abstract
ARTICLE
Open Access

oa

Impact of myelodysplasia-related and additional gene mutations in intensively treated patients with NPM1-mutated AML
Sibylle Cocciardi, Maral Saadati, Nina Weiß, Daniela Späth, Silke Kapp-Schwoerer, Isabelle Schneider, Annika Meid, Verena I. Gaidzik, Sabrina Skambraks, Walter Fiedler, Michael W. M. Kühn, Ulrich Germing, Karin T. Mayer, Michael Lübbert, Elli Papaemmanuil, Felicitas Thol, Michael Heuser, Arnold Ganser, Lars Bullinger, Axel Benner, Hartmut Döhner, Konstanze Döhner,

First published: 15 January 2025

Graphical Abstract
LETTER
Open Access

oa

High levels of global hydroxymethylation predict worse overall survival in MDS patients treated with azacitidine
Francesca Tiso, Florentien E. M. in 't Hout, Ruth Knops, Leonie I. Kroeze, Arno van Rooij, Arjan A. van de Loosdrecht, Theresia M. Westers, Saskia M. C. Langemeijer, Claude Preudhomme, Nicolas Duployez, Pierre Fenaux, Olivier Kosmider, Didier Bouscary, Aniek O. de Graaf, Joost H. A. Martens, Bert A. van der Reijden, Lionel Adès, Michaela Fontenay, Joop H. Jansen,

First published: 03 January 2025
REVIEW ARTICLE
Open Access

oa

Novel approaches in myelofibrosis
Steffen Koschmieder,

First published: 12 December 2024

Collections: Reviews
ARTICLE
Open Access

oa

A single-chain variable fragment-based bispecific T-cell activating antibody against CD117 enables T-cell mediated lysis of acute myeloid leukemia and hematopoietic stem and progenitor cells
Laura Volta, Renier Myburgh, Mara Hofstetter, Christian Koch, Jonathan D. Kiefer, Celeste Gobbi, Francesco Manfredi, Kathrin Zimmermann, Philipp Kaufmann, Serena Fazio, Christian Pellegrino, Norman F. Russkamp, Danielle Villars, Mattia Matasci, Monique Maurer, Jan Mueller, Florin Schneiter, Paul Büschl, Niclas Harrer, Jacqueline Mock, Stefan Balabanov, César Nombela-Arrieta, Timm Schroeder, Dario Neri, Markus G. Manz,

First published: 19 November 2024

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oa

PRC2-mediated apoptosis evasion is a therapeutic target of MDS/AML harboring inv(3)/t(3;3) and monosomy 7

Graphical Abstract

oa

Expanding the phenotypic and genetic landscape of congenital neutropenia through whole-exome and genome sequencing

Graphical Abstract

oa

Development of myeloid neoplasia associated with prolonged immune cell-associated hematotoxicity after CAR T-cell treatment of B-cell lymphoma: Should we surveille for pre-existing myeloid mutations?

oa

Applications of machine learning for immunophenotypic measurable residual disease assessment in acute myeloid leukemia

oa

Metabolism in hematology: Technological advances open new perspectives on disease biology and treatment

oa

Event-free survival in early polycythemia vera patients correlates with molecular response to ropeginterferon alfa-2b or hydroxyurea/best available therapy (PROUD-PV/CONTINUATION-PV)

oa

Comparing functional and genomic-based precision medicine in blood cancer patients

Graphical Abstract

oa

Implementation science in hemato-oncology molecular diagnostics in France via the Groupe des Biologistes Moléculaire des Hémopathies Malignes (GBMHM)

oa

Two distinct fetal-type signatures characterize juvenile myelomonocytic leukemia

Graphical Abstract

oa

Low-risk MDS—A spotlight on precision medicine for SF3B1-mutated patients

oa

Cell-free DNA for detection and monitoring of extramedullary AML relapse

Graphical Abstract

oa

Validation of the diagnostic potential of 17 immunophenotypic core markers defined by the ELN-iMDS-Flow Working Group in an independent cohort of patients with MDS

oa

HLA evolutionary divergence score after donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation

Graphical Abstract

oa

Cytopenic overt primary myelofibrosis at presentation: Analysis of outcomes in the prospective, real-world ERNEST-2 registry

oa

Diagnosis and treatment of AML in the context of WHO and ICC 2022 classifications: Divergent nomenclature converges on common therapies

oa

Disease characteristics and outcomes of acute myeloid leukemia in germline RUNX1 deficiency (Familial Platelet Disorder with associated Myeloid Malignancy)

Graphical Abstract

oa

Impact of myelodysplasia-related and additional gene mutations in intensively treated patients with NPM1-mutated AML

Graphical Abstract

oa

High levels of global hydroxymethylation predict worse overall survival in MDS patients treated with azacitidine

oa

Novel approaches in myelofibrosis

oa

A single-chain variable fragment-based bispecific T-cell activating antibody against CD117 enables T-cell mediated lysis of acute myeloid leukemia and hematopoietic stem and progenitor cells

Graphical Abstract

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oa PRC2-mediated apoptosis evasion is a therapeutic target of MDS/AML harboring inv(3)/t(3;3) and monosomy 7

Graphical Abstract

oa Expanding the phenotypic and genetic landscape of congenital neutropenia through whole-exome and genome sequencing

Graphical Abstract

oa Development of myeloid neoplasia associated with prolonged immune cell-associated hematotoxicity after CAR T-cell treatment of B-cell lymphoma: Should we surveille for pre-existing myeloid mutations?

oa Applications of machine learning for immunophenotypic measurable residual disease assessment in acute myeloid leukemia

oa Metabolism in hematology: Technological advances open new perspectives on disease biology and treatment

oa Event-free survival in early polycythemia vera patients correlates with molecular response to ropeginterferon alfa-2b or hydroxyurea/best available therapy (PROUD-PV/CONTINUATION-PV)

oa Comparing functional and genomic-based precision medicine in blood cancer patients

Graphical Abstract

oa Implementation science in hemato-oncology molecular diagnostics in France via the Groupe des Biologistes Moléculaire des Hémopathies Malignes (GBMHM)

oa Two distinct fetal-type signatures characterize juvenile myelomonocytic leukemia

Graphical Abstract

oa Low-risk MDS—A spotlight on precision medicine for SF3B1-mutated patients

oa Cell-free DNA for detection and monitoring of extramedullary AML relapse

Graphical Abstract

oa Validation of the diagnostic potential of 17 immunophenotypic core markers defined by the ELN-iMDS-Flow Working Group in an independent cohort of patients with MDS

oa HLA evolutionary divergence score after donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation

Graphical Abstract

oa Cytopenic overt primary myelofibrosis at presentation: Analysis of outcomes in the prospective, real-world ERNEST-2 registry

oa Diagnosis and treatment of AML in the context of WHO and ICC 2022 classifications: Divergent nomenclature converges on common therapies

oa Disease characteristics and outcomes of acute myeloid leukemia in germline RUNX1 deficiency (Familial Platelet Disorder with associated Myeloid Malignancy)

Graphical Abstract

oa Impact of myelodysplasia-related and additional gene mutations in intensively treated patients with NPM1-mutated AML

Graphical Abstract

oa High levels of global hydroxymethylation predict worse overall survival in MDS patients treated with azacitidine

oa Novel approaches in myelofibrosis

oa A single-chain variable fragment-based bispecific T-cell activating antibody against CD117 enables T-cell mediated lysis of acute myeloid leukemia and hematopoietic stem and progenitor cells

Graphical Abstract

oa

PRC2-mediated apoptosis evasion is a therapeutic target of MDS/AML harboring inv(3)/t(3;3) and monosomy 7

oa

Expanding the phenotypic and genetic landscape of congenital neutropenia through whole-exome and genome sequencing

oa

Development of myeloid neoplasia associated with prolonged immune cell-associated hematotoxicity after CAR T-cell treatment of B-cell lymphoma: Should we surveille for pre-existing myeloid mutations?

oa

Applications of machine learning for immunophenotypic measurable residual disease assessment in acute myeloid leukemia

oa

Metabolism in hematology: Technological advances open new perspectives on disease biology and treatment

oa

Event-free survival in early polycythemia vera patients correlates with molecular response to ropeginterferon alfa-2b or hydroxyurea/best available therapy (PROUD-PV/CONTINUATION-PV)

oa

Comparing functional and genomic-based precision medicine in blood cancer patients

oa

Implementation science in hemato-oncology molecular diagnostics in France via the Groupe des Biologistes Moléculaire des Hémopathies Malignes (GBMHM)

oa

Two distinct fetal-type signatures characterize juvenile myelomonocytic leukemia

oa

Low-risk MDS—A spotlight on precision medicine for SF3B1-mutated patients

oa

Cell-free DNA for detection and monitoring of extramedullary AML relapse

oa

Validation of the diagnostic potential of 17 immunophenotypic core markers defined by the ELN-iMDS-Flow Working Group in an independent cohort of patients with MDS

oa

HLA evolutionary divergence score after donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation

oa

Cytopenic overt primary myelofibrosis at presentation: Analysis of outcomes in the prospective, real-world ERNEST-2 registry

oa

Diagnosis and treatment of AML in the context of WHO and ICC 2022 classifications: Divergent nomenclature converges on common therapies

oa

Disease characteristics and outcomes of acute myeloid leukemia in germline RUNX1 deficiency (Familial Platelet Disorder with associated Myeloid Malignancy)

oa

Impact of myelodysplasia-related and additional gene mutations in intensively treated patients with NPM1-mutated AML

oa

High levels of global hydroxymethylation predict worse overall survival in MDS patients treated with azacitidine

oa

Novel approaches in myelofibrosis

oa

A single-chain variable fragment-based bispecific T-cell activating antibody against CD117 enables T-cell mediated lysis of acute myeloid leukemia and hematopoietic stem and progenitor cells