This special issue showcases recent progress, roadblocks and knowledge gaps in research and management of childhood cancers including the challenges faced in developing countries. It has been compiled by Guest Editor Cancer Reports editorial board member, Dr. Siddharth Agrawal (King George's Medical University, India). The cover image is based on the Original Article “Tell it as it is”: How Sisom prompts children and parents to discuss their cancer experience by Argerie Tsimicalis et al., https://doi.org/10.1002/cnr2.1173. Image courtesy of and funded by the Center for Shared Decision Making and Collaborative Research.