IFN-I signaling exacerbate liver pathology and contribute to sepsis following fatal Ehrlichia infection by promoting Ehrlichia replication and mediating detrimental inflammasome activation.

The American Heart Association (AHA) introduced Life's Simple 7 as a metric to define ideal cardiovascular health. We examined the association between cardiovascular health score (CHS) and prevalent nonalcoholic fatty liver disease (NAFLD) among Framingham Heart Study participants with varying genetic risk of NAFLD. Adhering to the AHA Life's Simple 7 metrics was associated with reduced odds of prevalent NAFLD, particularly for those at high genetic risk.

Soluble immune markers (SIMs) are associated with the risk of virological relapse in HBeAg-negative patients with chronic hepatitis B after discontinuation of nucleos(t)ide analogue therapy. Machine learning identified a combination of five SIMs (IL-2, MIG, RANTES, SCF, and TRAIL), which are highly predictive for virological relapse (AUC 0.89; CI: 0.5-1.1) and can be validated in an independent cohort (AUC 0.63; CI: 0.1-0.99).

Chronic viral hepatitis is associated with substantial morbidity and mortality worldwide. Our study shows good comparability of point shear wave elastography (pSWE) and transient elastography. pSWE is a promising tool for the prediction of liver-related events in patients with viral hepatitis, particularly in patients with cHCV.

We conducted a multicenter retrospective cohort study of metabolic dysfunction-associated hepatocellular carcinoma. In this cohort, cirrhosis was not associated with poorer survival, while history of liver imaging was.