The cover image is based on the Case Report Utility of coronary orbital atherectomy with guide-extension system for distally located undilatable in-stent restenosis: A case report by Hiroyuki Yamamoto et al., https://doi.org/10.1002/ccr3.5798.

The cover image is based on the Case Report Fine-needle aspiration cytology diagnosis of aspergilloma - A case report by Dilasma Ghartimagar et al., https://doi.org/10.1002/ccr3.5826.

Although cabergoline is reported to be rarely teratogenic, we reported a case of syndactyly in a toddler with maternal exposure to cabergoline. This underscores the necessity of restricting cabergoline prescription only for urgent cases in pregnancy.

It is important to focus on the diagnosis of splenosis or postsplenectomy thrombosis of the portal vein complicated by cavernous transformation of the portal vein and prehepatic, in which the systemic examination reveals normal findings.

An endotracheal tube can be used to remove the impacted subglottic foreign bodies to minimize damage to the surrounding airway tissue and avoid tracheostomy.

OFDI-guided OA, with a guide-extension system, could be useful for the treatment of distally located, undilatable ISR with hard neointima and calcified neoatherosclerosis, while preventing potential OA-related complications, such as crown entrapment.

The COVID-19 pandemic has urged the scientific community to focus on developing of vaccines, and the potential side effects on the cardiovascular system are unknown. Here, we reported a second-degree AV block in a man receiving a COVID-19 vaccine.

Abusing methamphetamine can be considered as an agent that can cause or affect the course of atypicalparkinsonian syndromes (APS), which may raise attention regarding preventing abusing these drugs.

Chronic pulmonary aspergillosis is a potentially serious disease that may threaten the post-COVID-19 patient's vital and functional prognosis. Yet, both the diagnosis and the treatment are challenging. Therefore, early clinical suspicion, chest CT scan, and screening for aspergillosis are important. Next, timely antifungal treatment based on international guidelines is recommended.

Concrescence is a rare developmental anomaly of dental tissues. This manuscript reported a case and analyzed the histological etiology and clinical diagnosis and treatment of concrescence from the sight of periodontal functional stimulation.

We reported a patient presented with 4-day acute painless bilateral visual loss, who was diagnosed to have idiopathic hypertrophic cranial pachymeningitis based on laboratory tests and MRI data, the visual acuity obviously improved after timely treatment. Therefore, Intracranial changes should be considered in patients with a sharp decline in visual acuity but with no obviously positive signs of the eye fundus.

Patients with Charcot–Marie–Tooth disease or HSMN1 and advanced Hodgkin lymphoma can be successfully treated with modified BEACOPP achieving complete remission without major aggravation of neurological symptoms.

Spontaneous renal tract rupture is a rare presentation and commonly results from ureteric obstruction. It should be considered in suspected renal colic and management will, however, depend on the cause and level at which rupture occurs.

Sjogren syndrome rarely can present with acute-onset, motor predominant peripheral neuropathy. In addition, neurological signs and symptoms are unusual to be presented as the first manifestation of this disease.

Despite the rarity of condition, any new-onset bone pain in patients with endometrial cancer should be assessed for bone metastasis.

Tension pneumothorax can present such as COVID-19 infection, leading to a delayed diagnosis, and may increase mortality. In the absence of risk factors, COVID-19 can be an independent risk factor for STP development with significant mortality rates.

Considering that COVID-19 patients are more prone to develop thromboembolism, appropriate workups must be done in case of relevant presentations. Given that immunomodulatory and immunosuppressant drugs are used to treat the inflammatory phase of COVID-19 patients may develop rare infections such as endogenous endophthalmitis.

In this new pandemic era, spinal cord injury can be a complication of SARS-CoV-2 infection. Because of its significant burden, physical medicine rehabilitation remains a pivotal specialty in managing COVID-19 disabilities.

Fibrate therapy is recommended for high-risk women undergoing in vitro fertilization due to hormonal changes that can raise triglyceride levels and increase the risk of fetal harm from hypertriglyceridemia.

Key messages of this case remains that musculoskeletal manifestations of the Hansen's disease should not be missed by clinicians.

This is the first report of large presacral Tarlov cysts (cerebrospinal fluid-filled perineural cysts) diagnosed during pregnancy in which a cesarean delivery mode was selected to avoid the risk associated with vaginal delivery.

Pneumoparotid refers to retrograde insufflation of air inside the parotid gland. In a patient with pneumoparotid accompanying sleep apnea syndrome, an oral appliance with an anterior opening to reduce intraoral pressure can be effective.

Usual medication plus psychological treatment can be helpful in treating unexplained regression in Down syndrome. However, when a patient has a history of aggression toward others, clinicians should carefully monitor the risk of acute aggression.

Isthmocele's diagnosis had been neglected in the initial evaluation of the presented case. Physicians should pay more attention to isthmocele's impact mechanisms on secondary infertility, implantation failure, and associated attributes.

In the clinical laboratory, irrational results can signal the presence of analytical interferences, such as hemolysis, icterus, lipemia, and paraproteinemia. Although specimen dilution or the use of various measurement methods may not totally resolve the interference, they can assist in diminishing it and obtaining a reproducible result.

Perampanel markedly improved clinical seizures in a patient showing a Rett-like phenotype with a de novo 960-kb deletion at 9q34.11 encompassing the STXBP1 gene. Perampanel may be useful for treating drug-resistant epilepsy.

Choroidal neovascularization (CNV) is a rare complication of the multiple evanescent white dot syndrome (MEWDS). It can develop even when there is no evident inflammatory activity. Therefore, a long-term follow-up of such patients is important.

Small bowel obstruction is one of the most common causes of emergency admission with abdominal pain often requiring surgical intervention. Small bowel obstruction (SBO) is a common cause of emergency admission to surgical ward. The etiologies for the majority of these cases include postoperative adhesions and hernia. However, acute appendicitis presenting with SBO due to appendico-ileal knotting is a very rare and unsuspected condition in an emergency scenarios.

Pancreatic pseudocysts commonly occur in patients with a history of pancreatitis or trauma. Giant pancreatic pseudocysts, which are measured 10 cm or more in primary diameter, are rare and can be a surgical challenge.

Thoracic outlet syndrome is an uncommon phenomenon, particularly the vascular subtype. Our purpose is to remind its natural history and to highlight the role of timely diagnosis and the challenging management of this disorder.

We present a patient with the first known presentation of 15q11-q13 compound interstitial triplication and duplication spanning the largest region of the Prader–Willi Angelman Critical Region known till date.

If an abdominal extension is observed as in this case, it is necessary to consider ascites retention in the management of aggravated PE.

Cavernous hemangioma (CH) accounts for 0.6% of all urinary bladder tumors. CH should be considered in the differential diagnosis of childhood urogenital mass. CH are rare benign tumors, with life-threatening complications when diagnosis is delayed. CH is insensitive to chemotherapy, thus surgery is effective in low-resource setting.

Implant-supported prostheses can be an effective and reliable solution for patients suffering from chronic dermatological oral manifestations of bullous disorders.

Follicular mucinosis may show a combination of brownish yellow dots and red dots in a dermoscopic examination. Dermatologists need to consider follicular mucinosis when these dermoscopic findings are obtained.

Cutis verticis gyrata is a rare neurocutaneous syndrome with mainly anesthetic impact. A rigorous clinical examination with a minimal workup is required to eliminate a secondary or a primary non-essential form and to assess interdisciplinary management.

PTA was performed successfully using a balloon to expand and restrictively tear the longitudinal axis of the RA. The method may be a useful measure of promoting maturation of AVF in diabetic nephropathy.

Concurrent pulmonary and hepatic hydatid cysts can be managed with a single-stage surgical procedure. Following such a procedure, the patient in this case experienced a complete recovery.

A combination of cardiac tamponade and myocardial infarction with effusion around the ascending aorta tends to be diagnosed as an acute aortic dissection complicated with coronary malperfusion, but free-wall rupture should be ruled out.

Congenital heart defects are common among Ellis–Van Creveld syndrome patients, and need to be managed to enhance the quality of life and improve prognosis. Partial atrioventricular septal defect is among the most common congenital heart defects in these patients, and double orifice mitral valve is encountered frequently.

Systemic infectious diseases can be confused with malignant hematological diseases, because they tend to invade the bloodstream and even bone marrow. Bone marrow aspiration can help full out the differential diagnoses.

We presented a case of COVID-19 pneumonia by the Omicron variant in a 19-year-old woman. This case suggests that the Omicron variant can cause pneumonia even in young patients without risk factors.

We want to transmit to doctors who could one day face a swelling on a Charcot foot that the hypothesis of false arterial aneurysm must be part of the diagnoses to be evoked among infectious and tumoral etiologies. Ignoring this diagnosis can lead to serious consequences.

General and pediatric dentists should be familiar with the clinical and the imaging features of regional odontodysplasia so that an appropriate diagnosis and adequate therapeutic strategy are performed.

The diagnosis of Listeria endocarditis and spondylodiscitis is challenging, especially in the absence of fever. In our case, the patient had no fever and had high CRP level and prosthetic valve. Blood cultures taken for polyarthritis were positive.

Nipple adenoma is a rare, benign pathology that requires adequate excision and satisfactory surgical reconstruction. Our excision and double purse-string suture method covered both requirements, forgoing necessitation of special training of the surgeon or expensive equipment, thus rendering it a simple, safe, and effective treatment option.

AT is a rare neurodegenerative genetic disorder caused by biallelic mutations in the AT-mutated gene. Glucocorticoid analogs can improve neurological symptoms in AT patients. Taking oral dexamethasone at a dose of 0.075 mg/kg/day for 28 days can improve ataxia symptoms in AT patients.

We describe the first case of intra-articular osteoid osteoma of the capitulum presented as elbow pain, extension lack, and sensation of click in joint flexion. Surgical treatment either arthroscopic or open is more in use in tumor location than cortical osteoid osteoma. Radiofrequency ablation should be used with extreme caution.

When acute cholecystitis is encountered in a patient with a left ventricular assist device, performing laparoscopic cholecystectomy (LC) after reducing inflammation with PTGBD, instead of performing an emergency LC may be useful.

Merkel cell carcinoma is a rare cutaneous malignancy that should not be overlooked when evaluating an individual with a new skin lesion and possible metastasis, especially in those with history of other cutaneous malignancies such as melanoma.

A variant in a form of IDUA multiple exons deletion (deletion of exon 9′–3′) may indicate early severe MPS I phenotype. Moreover, this variant might be associated with cardiac involvement as its first manifestation. Establishment of the genetic diagnosis permits genetic counseling, prevents patients from undergoing unhelpful diagnostic procedures and allows for accurate prognosis.

Chondrosarcomas of the paranasal sinuses are rare and pose diagnostic and treatment challenge. Rarely will they initially present with ocular symptoms. A comprehensive range of medical investigation enables timely recognition and treatment.

Endomyocardial fibrosis is a rare cause of restrictive cardiomyopathy. Its etiology is poorly understood with a challenging diagnosis and treatment. It should be considered as a cause of unexplained chest pain and heart failure.

Recognize abdominal crepitus and air in the subcutaneous tissue as an entity that requires prompt and aggressive management; and identify key elements from the medical history and risk factors that could lead to its development.

Labyrinthitis is the inflammation of the inner ear and can result in labyrinthitis ossificans. The T2-weighted magnetic resonance imaging can play a crucial role in the diagnosis of labyrinthitis ossificans.

Orthopedic surgeons should be aware of the seriousness of vascular complications in the event of intrapelvic migration of the lag screw from locking trochanteric nail. Thus, they had to be more careful and not trivialize this daily surgery.

When a late pseudoaneurysm of ascending aorta after cardiac operation is diagnosed, the surgical correction should not be delayed for the prevention of life-threatening complications.

There is likely an association of Bell's palsy with preeclampsia during pregnancy. It is imperative to initiate screening for preeclampsia in pregnant women with Bell's palsy to detect and treat it early to improve the maternal and perinatal outcomes.

Horizontal stenting via retrograde route for recurrent ruptured posterior communicating artery aneurysm after clipping.

Thoracolumbosacral MRI revealing no evidence of spondylodiscitis adjacent to psoas collection.

For patients with COVID-19 disease progressing toward cytokine storm syndrome (CSS) in the presence of significant neutropenia, combined tocilizumab and G-CSF therapy circumvent potential therapeutic limitations leading to safe outcomes.

Gastrointestinal hemangiomas are uncommon and the presentation of the patient depends on the location of the tumor. Diagnosis is usually established following surgery and histopathology. Surgical resection is usually curative.

Pure Sertoli cell tumors are rare variant of ovarian Sertoli-Leydig cell tumors. The prognosis is excellent if detected early and resected timely.