Sonazoid-enhanced ultrasound assistant laparoscopic radiofrequency ablation is safe and effective to treat liver malignancy.

Early relapse post-ASCT in MM makes patients suffer adverse outcomes, which is so far unpredictable. This study retrospectively enrolled data of transplant-eligible MM patients from multicenters in China and established a predictive nomogram for ER. The C-index demonstrates good predictive accuracy for survival and the calibration curve for the probability of survival showed good agreement between the prediction by the nomogram and actual observations, which could be used to modify the post-ASCT strategy for those patients.

We retrospectively analyzed the prognosis and predictors of survival in patients with advanced non-small cell lung cancer who developed symptomatic thromboembolism. In this study, the prognosis of patients with cerebral infarction tended to be poorer than that of patients with pulmonary embolism. In addition, we showed that D-dimer levels were a promising prognostic predictor in patients who developed cerebral infarction.

Preoperative diagnosis of urachal carcinoma: Imaging (A) , cystoscopy (B), tumor markers (C) and urine FISH (D).

Enrichment and characterization of circulating tumor cells (CTC) can aid more effective prostate cancer detection. CTC based prostate cancer detection can reduce false negatives as well as false positives.

Metformin users showed lower rates of Accident & Emergency and Inpatient attendances, shorter inpatient length-of-stay and lower attendance-related costs compared to metformin non-users.

In this phase 2 randomized clinical trial to examine activity and safety, and to determine optimum dose of nab-PTX in patients with previously treated stage IIIB/IV or postoperative relapsed NSCLC, both 100 and 70 mg/m2 of nab-PTX monotherapy were active in patients with previously treated advanced NSCLC. Since the 70 mg/m2 dose has a better safety profile and numerically favored median overall survival, 70 mg/m2 on days 1, 8, and 15 every 4 weeks would be the optimal dose and schedule for nab-PTX during treatment of NSCLC.

All-rans retinoic acid combined with low-dose apatinib might be a potential efficacy therapeutic option for patients with recurrent/metastatic adenoid cystic carcinoma of the head and neck

We analyzed the clinical and genetic features of 61 MS cases. We performed genetic abnormalities based risk stratification based on gene mutations and fusion genes identified by RNA-seq on FFPE. Our study suggested that RNA-seq on FFPE could be as markers for MS risk stratification since fresh samples are usually unavailable.

This study aimed to explore the association between ICIs and hepatic failure. Data from the FAERS database were analyzed for Reporting odds ratios (ROR) and information component (IC).

Response to induction chemotherapy is an important predictor of prognosis in HPV-positive and -negative oropharyngeal squamous cell carcinoma.

The prognosis of lung cancer is still poor despite several treatment strategies. A retrospective cohort studywas employed among 151 adult lung cancer patients to assess survival outcomes. The study revealed 75.5% one-year and 66.7% two-year survival rates, with most patients having distant metastasis in the follow-up period.

The present study evaluated a real-life cohort of 210 patients with unresectable or advanced hepatocellular carcinoma who received treatment with lenvatinib plus anti-programmed death-1 antibodies between October 2018 and March 2022. The results are encouraging, with median overall survival of 17.2 months and objective response rate of 28.1%.

This figure represents our research of comparing the survival outcomes for multifocal recurrent hepatocellular carcinoma patients meeting the Barcelona Clinic Liver Cancer stage A who underwent repeat hepatectomy alone or repeat hepatectomy combined with intraoperative radiofrequency. The results may propose some new valuable suggestions and treatment decision-making.

A serum procalcitonin concentration >0.4 ng/mL was significantly associated with confirmed bacterial infection in patients after receiving chimeric antigen T-cell therapy. Procalcitonin may be a useful marker for differentiating bacterial infection from cytokine release syndrome in chimeric antigen T-cell therapy recipients.

Risk factors for second malignancies among patients with myeloproliferative neoplasms.

The adrenal gland's response to stress is impaired in most pediatric cancer patients receiving chemotherapy, whether or not they are taking steroids. Intake of dexamethasone and posaconazole and a time period of ≤7 days from the last glucocorticoid intake were additional risk factors for an impaired adrenal response.

In the present study, age, grade, tumor size, positive lymph node, N stage, M stage, and chemotherapy were identified as prognostic parameters for survival in patients with malignant myofibroblastic tumors. These factors were included in the construction of the nomogram. Evaluation of its predictive performance implied the superior sensitivity and specificity of the model and the higher accuracy of the outcomes than the AJCC system. The established nomogram may assist patients in consultation and help physicians make appropriate clinical decisions.

This is the first study to evaluate the association between 28 indirect markers of frailty and clinical outcomes in advanced lung cancer patients treated with PD-1 inhibitors.

Not all patients with advanced HCC can benefit from anti-PD-1/PD-L1 therapy, biomarkers for selecting patients for treatment are urgently needed. Tumor PD-L1 expression was significantly associated with improved ORR in HCC patients. The ORR and DCR in patients with positive PD-L1 expression were 26% and 66%, versus 18% and 69% in patients with negative PD-L1 expression.

The curative approach for gallbladder cancer (GBC) is radical cholecystectomy with adjuvant chemotherapy. GBC has non-specific symptoms, so screening/early detection is not possible. We report that 90% of GBC patients presented with late-stage inoperable disease. Patients with late-stage disease who received chemotherapy had significantly better survival over those who did not (p < 0.0001). Our real-world data suggests that GBC is a chemosensitive disease. Clinical trials in low-middle income countries to reposition available therapies are urgently required.

Stage III-N2 lung pure mucinous adenocarcinoma (PMA) tended to appear more in lower lobes, with higher differentiation degree, earlier T stage, and more positive lymph nodes(LNs) than other adenocarcinoma. The prognosis of resectable III-N2 PMAs was worse than other adenocarcinoma. Patients with ≤7 positive LNs benefited from PORT and those with >7 positive LNs benefited from chemotherapy.

Systematical screening including NGS immunosequencing of B-cell non-Hodkin lymphomas at two German University Meidcal Ceners diagnosed before and after introduction of SARS-CoV-2 vaccines. There was no evidence that the current SARS-CoV-2 vaccines could serve as a trigger for lymphomagenesis.

In advanced gastric cancer treated with nivolumab, patients with mixed progression had a longer progression-free survival than those with systemic progression. Lung and liver metastases had a poorer response to nivolumab than lymph node metastases.

A multi-center retrospective study, investigated patients of MN based on next-generation sequencing (NGS).

In the near to intermediate term, partial gland ablation with focal cryotherapy was found to be a moderately effective and relatively safe treatment for men with intermediate risk prostate cancer. We also found that treatment success, that is, eradication of the cancer, is best determined by MRI-guided biopsy, rather than by PSA levels or MRI findings.

Patients who do not achieve a pathological complete response (pCR) after neoadjuvant systemic treatment (NST) have a significantly worse prognosis. This study aimed to explore the most useful form or combination of Ki-67 including the baseline Ki-67 at biopsy before NST (Ki-67_B), the percentage change in Ki-67 before and after NST (Ki-67_C), and the terminal index of Ki-67 after surgery (Ki-67_T), that can provide prognostic information to non-pCR patients. We retrospectively reviewed 499 patients, and 388 patients did not achieve pCR. The forecasting model combining Ki-67_B and Ki-67_C showed a significantly higher area under the curve (AUC) at years 3 and 5 than Ki-67_T (p = 0.029 and p = 0.022, respectively). The combination of Ki-67_B and Ki-67_C is superior to Ki-67_T for predicting DFS, especially at longer follow-ups.

Oncological patients can benefit substantially from treatment with immune checkpoint inhibitors. However, there is a growing awareness of immune-related adverse events, especially neurological adverse events (nAE). MCP-1 and BDNF are potentially the first clinical-class nAE predictors for patients under immune checkpoint inhibitor therapy.

Liquid biopsy guides anti-EGFR rechallenge therapy in CRICKET and CAVE trails.

Gastric cancer has a high incidence of LVI/PNI, which was closely associated with disease progression. LVI/PNI could serve as an independent risk factor for lymph node metastasis and the prognosis of patients with curative resected gastric cancer. These findings will be helpful in predicting survival outcomes more accurately and establishing individualized treatment plans.

This article revealed that localized Ewing sarcoma patiebts were stratified into two groups and received different intensities of chemotherapy, which achieving good efficacy.

NPM1mut/FLT3-ITD(−)/TET2(+) is identified as an unfavorable prognostic subset in NPM1mut/FLT3-ITD(−) patients. Induction containing intermediate-dose cytosine arabinoside improves outcome in NPM1mut/FLT3-ITD(+) patients. Clinicopathologic parameters, including age and white blood cell count, convey an outcome risk modulation for NPM1mut/FLT3-ITD(−), as does CD34 for NPM1mut/FLT3-ITD(+).

In this retrospective review, 20 patients were treated with gemcitabine plus nab-paclitaxel and the median PFS was 9 months (95% CI, 5.7–20.7). Overall, 17 of the 20 patients (85%) achieved a clinical benefit (complete response 5%, partial response 55%, or stable disease at 3 months 25%). For platinum-sensitive disease and platinum-resistant disease, the median OS were 38.7 months (95% CI, 5.8–63.1) and 31.2 months (95% CI, 12.8–51.8), respectively (p = 0.4306). This regimen is a viable and well tolerated option for patients who are intolerant to paclitaxel or carboplatin because of allergic reactions.

The controlling nutritional status (CONUT) score is a prognostic marker for survival in patients with nasal-type extranodal NK/T-cell lymphoma. Patients with CONUT scores <2 had higher complete response and overall response rates, as well as better overall and progression-free survival rates. A CONUT score ≥2 was identified as an independent poor prognostic factor for both overall survival and progression-free survival and could be used to stratify risk in low-risk patients.

Two cycles of IC is recommended before radiotherapy for patients with LANPC if the initial metastatic cervical lymph node volume is not dominating. Otherwise, three cycles of IC is recommended to further reduce the cervical node volume.

In this retrospective analysis of 267 newly diagnosed nasal-type extranodal NK/T-cell lymphoma patients, LVDP (L-asparaginase, etoposide, dexamethasone and cisplatin) and GLIDE (gemcitabine, L-asparaginase, ifosfamide, dexamethasone and etoposide) chemotherapy regimens showed similar short-term and long-term efficacies, with 85.5% ORR and 62.2% CR rates, and 64.3% PFS and 68.5% OS rates at a median 71-month follow-up. However, LVDP was associated with milder treatment-related toxicities compared to GLIDE, even after adjusting for confounders via PSM. These findings suggest that LVDP could be a preferable option for patients with nasal-type extranodal NK/T-cell lymphoma.

We retrieved Japanese sarcoma patients with brain metastasis (BM) in a single institution and analyzed the prognostic factors for BM. We have identified several prognostic factors for brain metastases. We believed that our data is useful for understanding the prognosis and treatment strategy for BM of sarcoma.

1.By retrospectively analyzing the clinical data of 145 CCA patients with hepatic resection, we determined the optimal LMR cutoff value according to the receiver operating characteristic (ROC).

2.We found there was a longer OS in CCA patients of the high LMR group than the low LMR group.

3.Preoperative LMR was a vital prognostic factor to predict the prognosis of CCA patients with hepatic resection and provided additional prognostic value beyond standard clinicopathological parameters.

Using prospectively collected population-based data, this self-controlled case series investigated the link between immune checkpoint inhibitors (ICIs) use and myocardial infarction (MI) in Chinese patients. Compared to the year prior to ICI use, MI incidence increased significantly in the first 90 days of exposure, but not in later exposure periods nor post-exposure.

Presence of TLS was associated with favorable survival in stage ILUAD, which was featured by special immune and clinicopathological profiles.

With the advances in treatment for colorectal liver metastases (CRLM), accurately predicting recurrence-free survival post hepatectomy has become increasingly important. This study retrospectively analyzed patients with CRLM who underwent surgery with actual follow-up over 5 years; we found that approximately one quarter of patients got a potential cure chance without recurrence. Patients with RAS wild-type, preoperative CEA <10 ng/mL, and liver metastases ≤3 were shown to have a higher chance of cure rate after hepatic resection for CRLM.

SIRI, a reproducible and easily accessible hallmark, is considered a potent and independent prognostic indicator in our study. Compared to the NCCN-IPI, the SIRI-PI presents good performance, which could aid in appropriate decision-making and provide added value for categorizing high-risk patients and those with severe complications.

In this study, we used osteosarcoma patients over 60 years of age from the SEER database as the modeling population, identified statistically significant variables by means of multiple regression analyses, and used these variables to build nomograms that can accurately predict the risk of OS & CSS in osteosarcoma patients over 60 years of age. In addition, this study collected data from multiple medical centers as an external validation population to assess the accuracy and precision of the prediction models we have constructed.

This is the first report illustrating the evolving patterns of multiple myeloma (MM) diagnosis and treatment and a reflection of the dynamic landscape of China's myeloma management. Chinese MM patients evidently benefited from comprehensive baseline evaluation and novel-drug-based (proteasome inhibitors [PIs] and immunomodulatory drugs [IMiDs]) standardized initial treatment.

Overall, our study found that mucinous adenocarcinomas (MCAs) were more commonly located in the right colon, high grade, and prevalent in younger patients (<40 years). They exhibited strong expression of MUC2 and Bcl-2 and showed less aberrant p53 nuclear staining. In adjusted multivariate survival models split by tumor location, MCAs of the rectum were associated with poorer outcomes relative to NMCAs (HR 1.85, CI 95% 1.15-2.97). Our results support the concept that patients with MCAs located in the rectum should be considered for rigorous treatment regimens.

Neuroendocrine carcinoma (NEC) of the breast is a very rare pathological type with few studies illustrating the prognosis compared with invasive ductal carcinoma (IDC). Our team used propensity score matching to make a 1:3 match between NEC and IDC. Thus, 153 patients with IDC and 51 patients with NEC were analysed. Compared to patients with IDC, patients with NEC had a worse disease-free survival (HR = 2.94, 95% CI: 1.69–5.12, p < 0.001).

Nasal vestibulitis symptoms are common in patients receiving chemotherapy, especially thosereceiving paclitaxel, docetaxel, and bevacizumab. Further investigations into treatments of thissymptom complex are warranted.

This preliminary report demonstrates that CD28/CD27- and 4-1-BB-equipped CAR T-cells have comparable effectiveness and safety indices in treating children with relapsed/refractoryacute myeloid leukemia.

We collected data from 325 consecutive CML patients followed at our institution, of whom 67 tested positive for SARS-CoV-2. We found out that the death rate observed in our serie was not different from that observed in national data. Moreover, the risk of hospitalization was significantly reduced in vaccinated patients or in those taking bosutinib.

In this study, we investigated the antitumor effect of Blue light (BL) on Synovial sarcoma (SS). Here, we found that BL induced apoptosis via the ROS-mitochondrial signaling pathway, and autophagy was activated in response to the production of ROS, which protected SS cells from apoptosis. Therefore, BL is a promising candidate for the development of an antitumor therapeutic strategy targeting SS.

The present study demonstrated that HER3 and MET were not directly associated with each other in CRC but cooperated for the cellular and tumor growth of CRC. In this context, the combination of anti-HER3 (patritumab) and anti-MET (PHA665752) drugs was definitely effective against HER3/MET-high SW1116 CRC cells, indicating the potential of the dual inhibition of HER3 and MET as targeting therapy in human CRC.

Combination with bevacizumab and CCR2 inhibitor demonstrated a sustained synergistic effect. The effect mechanisms included inhibitions of both angiogenesis and the CCR2B-MAPK pathway. The effect mechanisms were independent of antitumor immunity.

By examining in detail the function of genes that are highly expressed in side population (SP) cells exposed to hypoxia, we clarified the contribution of the hypoxia-ROS-HMOX1 axis to proteasome inhibitor resistance in hypoxic environments. This axis might also be involved in hypoxia-induced MafB expression.

Identifying YAP as a key mediator of hypoxia-induced mesenchymal TNBC cell migration based on the following evidence. (1) Hypoxia triggers YAP nuclear translocation at high cell density in mesenchymal TNBC; (2) Hypoxia only promotes mesenchymal TNBC cell migration, and YAP plays a crucial role in cell migration under hypoxia; and (3) Hypoxia promotes focal adhesions activation to support mesenchymal TNBC cell migration and YAP is also required for focal adhesions activation.

TPX2 can interact with Lamin A/C and modulate its stability by regulating the level of p-Lamin A/C (Ser22) and degradation of Lamin A/C in OC cells, targeting cell apoptosis.

GTN057, a komaroviquinone derivative, induced myeloma cell death in vivo. No significant hematological or systemic toxicity was observed in vivo. The pharmacokinetic and pharmacological actions of GTN057 are also studied.

A pre-angiogenesis inhibitor strategy improves immune checkpoint inhibitor effects by improving CD8 infiltration and drug delivery.The current clinical protocol of administering AI and ICI on the same day results in ICI acting when vascular normalization is insufficient to mobilize CTL in the tumor tissue. In contrast, the anti-tumor effect is enhanced when AI is administered several days before ICI, as ICI is given after vascular normalization and the number of immune cells infiltrating into the tissue has increased.

G4-CSSD restorestumor suppressor genes expression to inhibit tumor progression. CSSD with G quadruplex (G4) adsorbs microRNA like a magnet, thus releasing tumor suppressor genes and restoring their expression. So as to inhibit the progression of malignant tumor.

Hypoxia upregulated lncRNA RP11-367G18.1 variant 2 which was associated with p300-mediated chromatin modifying complex to activate H4K16Ac marks. RP11-367G18.1 variant 2 increased the levels of H4K16Ac on the promoter of hypoxia-regulated genes leading to EMT and tumor metastasis.

Dihydroorotate dehydrogenase exerts an anti-tumor effect in mice bearing Ewing's sarcoma, and be identified as a therapeutic target for Ewing's sarcoma.

The screening process of small molecular chemical drugs regulating transcriptional PD-L1 via cell-based high-throughput screening system.

FOXL2 promotes cell proliferation and metastasis in NSCLCmiR-133b downregulates FOXL2 by targeting the 3’-UTR of FOXL2.

Thymic epithelial tumors originating from thymic epithelial cells (TECs) are classified into six types of thymomas (Type A, AB, B1-B3 thymomas, and micronodular thymoma with lymphoid stroma [MNT]) and thymic carcinoma (TC). Despite the clear distinction between cortical (cTECs) and medullary TECs (mTECs) in physiology, the cell of origin of each TET has remained enigmatic. In the current study, we confirmed the expression of AIRE, an mTEC-specific transcriptional regulator, in most TCs at both protein and mRNA levels. Furthermore, our bioinformatics approach has revealed that TCs hold molecular characteristics of multiple mTEC subpopulations, suggesting their cell of origin as mTECs.

Developement and validation of a COVID-19 comordity score for cancer patients. The total cancer patient cohort was split into training (70%) and validation (30%) sets. In the training set, comorbidities associated with the risk of developing a severe/fatal form of COVID-19 were identified and the score weights were estimated. The score performances were then assesed in the validation set, by areas under the receiver operating characteristic curve (AUC) and calibration plots.

This study used a multilevel approach to examine the effects of role, race, and ADI on health outcomes and psychosocial factors among patients with PCa and their partners, controlling for various demographic and cancer-related covariates. Our work contributes to a more comprehensive understanding of PCa disparities than previous research focusing on individual- and/or family-level factors (e.g., race and role). In addition to personal- and family-focused strategies, supportive care programs should be tailored at multiple levels and provide adequate support to address neighborhood resource disparities, and ultimately, to reduce PCa disparities for patients and their partners and improve their health outcomes.

In this population-based, cross-sectional study, the utilization rates of conservative management were significantly higher in low socioeconomic status (SES), unmarried and urban patients diagnosed with low-risk prostate cancer. Unmarried status and low SES were associated with worse overall survival among patients undertaking active surveillance/watchful waiting. The utilization of conservative management was affected by socioeconomic factors, which might serve as a barrier of treatment decision-making and targeted a population in need of social support.

Young women with cancer report having received information about potential treatment-related impact on sex life to a lesser extent than men, and there is also a variation across cancer types. The majority of recipents recalled being informed that there was "some risk" of sex life being affected, see figure below. Routines clarifying when to discuss these issues are recommended to improve sexual health communication with young patients in cancer care.

The pandemic continues to impact cancer care. We observe significant declines in cancer screening CTs through the end of 2021. Concurrently, we observe a 2x increase in initial cancer workup CTs and a 2.4x increase in active cancer CTs in the ED during a time period following the introduction of vaccinations (20th December 2020-30th October 2021), suggesting a boom of new cancers and more cancer exams associated with emergency level acute care.

Age-standardized mortality rates from gastric cancer per 100,000, 2015-2019, in men and women in selected countries

The incidence and IB mortality of PASC have been steadily increasing in recent years, manifesting that the preventive and treatment measures of PASC are not ideal. Therefore, we must identify the significance of this condition as soon as possible and commit greater attention and resources to it. This can help us further understand PASC and develop more targeted and standardized preventive and therapeutic measures.

elomere length and hepatocellular carcinoma in Asian and European populations using mendelian randomization.

This study describes four actions clinicians can use to support hope across culture and resource setting, which ultimately improve parental outcomes and facilitate clinical relationships.

The epidemic of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) has remarkably changed the landscape of head and neck squamous cell carcinoma with the potential to improve outcomes and decrease treatment morbidity uniformly across demographic groups. This study evaluated the combined influence of race and socioeconomic status (SES) on OPSCC survival stratified by HPV status. Survival disparities between patients of high and low SES census tracts and Black and White race remained despite the increase in HPV-related disease. Black patients with OPSCC had lower survival than patients of other races regardless of HPV status. High SES was protective of the adverse effects of race, although there remains a disparity in outcomes among Black and non-Black patients, even in high SES populations.

Compared with the unscreened group, initiation of screening after 50 years was associated with a greater reduction in cumulative incidence and mortality in 10 years follow-up compared with initiation before 50 years.

This study aimed to assess the association between kidney function decline and cancer-related mortality among community-dwelling elderly individuals. In Cox proportional hazard models, participants with rapid eGFR decline had an increased risk of cancer mortality compared to those without rapid eGFR decline. In the analysis of site-specific cancer mortality risk, rapid eGFR decline was associated with six site-specific cancer mortality, namely gastrointestinal tract, hepatobiliary, lung, prostate, urinary tract, and hematological malignancies.

Burden of chemotherapy-induced myelosuppression among patients with extensive-stage small cell lung cancer in community oncology practices.

Age-standardized death rate (per 100,000) in 2019 (A) and the percentage change in the age-standardized death rate from 1990 to 2019 (B) rates of cancer deaths attributable to high fasting plasma glucose in the Middle East and North Africa (MENA) region, by sex and country.

This study combines several machine-learning and bioinformatic analysis methods to explore the correlation of peripheral and tumor-infiltrating immune cells with patient outcomes in ovarian cancer. The results suggest that both peripheral blood markers and TICs can be used as prognostic predictors in patients with ovarian cancer, and CXCL9, CD79A, MS4A1, and MZB1 may be potential therapeutic targets for ovarian cancer immunotherapy.

This article revealed that FBXO43 is overexpressed in HCC liver tissues at the RNA and protein levels and served as an independent prognostic factor for patients with HCC.

DNA damage repair (DDR) deficiency leads to genomic instability and oncogenesis and is prevalent in esophageal squamous cell carcinoma (ESCC). Using whole-exome and transcriptome sequencing data from Taizhou and TCGA, we demonstrated that DDR alterations could impact mutational processes and immune cell infiltration in ESCC. The suppression of HFM1 and NEIL1 could play a crucial role in ESCC progression and may also serve as prognostic markers.

Visualization of differentially expressed genes (DEGs) identified between early-onset colorectal cancer (EOCRC) and late-onset colorectal cancer (LOCRC). (A) DEG heatmap. Genes were sorted in accordance with their fold-change values. The top and bottom rows represent upregulated and downregulated genes in the EOCRC patients, respectively. (B) Pathway terms associated with the DEGs. (C) Gene ontology terms associated with the DEGs.

Lactate-related gene signature (LRGS) based on 4 lactate-related genes were developed and validated in CRC patients to predict clinical outcomes and provide individualized treatment recommendations. Patients with higher LRGS showed worse outcomes in different cohorts. Higher LRGS indicate better immunotherapy response, while lower LRGS indicate better sensitivity to targeted drugs.

A copper metabolism-related gene signature was identified as a prognostic model for glioma, and the prognostic model has good accuracy in predicting patient outcomes in both TCGA and CGGA cohorts. Besides, the high-risk group had higher levels of immune cell infiltration, immune checkpoint genes expression, and higher tumor mutational burden, suggesting that they might be more likely to benefit from immunotherapy. Our study can provide a reference for the diagnosis and treatment of patients with glioma.

Functions of CDCA8 in hepatocellular carcinoma. The expression of CDCA8 regulated the expression of tumor related proteins such as P53, PPAR, MYC etc. High level of CDCA8 activating the Notch pathway. Moreover, CDCA8 take part in the cell cycle and related to immune invasion. High level of CDCA8 means bad tumor status and poor survival in patients.