The aim of this review article is to discuss esophageal anastomotic leak, and describe modern treatment approaches. Endoluminal vacuum therapy (EVT, E-VAT)may be the most promising therapeutic strategy for the most dreaded complication. EVT (E-VAT) also has good commercial prospects.

Advanced non–small cell lung cancer patients experiencing intolerable adverse events (AEs) from tyrosine kinase inhibitors (TKIs) who received subsequent epidermal growth factor receptor (EGFR)-TKIs treatment, had better overall survival (OS) compared to patients receiving chemotherapy (C/T) or no treatment. Patients undergoing subsequent EGFR-TKIs had better OS than patients who did not discontinue because of AEs.

Left: Micronodular thymic epithelial cell nests, which exhibited pan-cytokeratin immunoreactivity by immunohistochemical staining (indicated by arrows) and lymphoid cell stroma (indicated by arrowheads). Right: Micronodular thymic epithelial cell nests and stromal lymphoid cells, indicated by arrows and arrowheads, respectively, was also found in three-dimensional culture.

Study flowchart of endobronchial ultrasound-guided re-biopsy after epidermal growth factor receptor-tyrosine kinase inhibitor failure.

The working model describes the mechanism of FBP1. The expression of FBP1 was increased in gefitinib-resistant lung cancer cells when stimulated by β-elemene. The upregulation of FBP1 bound to STAT3 and inhibited the phosphorylation of STAT3, resulting in the altered expression of apoptosis-related genes and leading to gefitinib sensitivity

We investigated the significance of serum S100A4 and FDG accumulation in predicting prognosis after lung resection for lung cancer with interstitial pneumonia. S100A4 and FDG accumulation were significant predictors of cumulative incidence of death from other than lung cancer (CIDOL) in multivariable analysis. CIDOL was significantly higher in patients with high S100A4/FDG (+).

circRARS (circular RARS) is upregulated in non-small-cell lung cancer (NSCLC) tissues and positively correlated with smoking state, lymph node metastasis, and higher tumor stages. NSCLC patients with high expression of circRARS have poor overall survival. Moreover, circRARS accelerates the proliferation, invasion, and migration of NSCLC cells in vitro. Furthermore, circRARS positively regulates lactate dehydrogenase LDHA activity and its expression in transcription level. Downregulated circRARS decreases glucose consumption and lactate production, and compromises aerobic glycolysis in NSCLC cells. In short, circRARS can promote glycolysis and tumor progression in NSCLC by regulating LDHA.

The new strategy with one chest tube plus pleural catheter is noninferior to double-chest-tube drainage after upper pulmonary lobectomy of uniportal VATS, offers superior pain control, and is recommended.

LINC02323 sponges miR-1343-3p and miR-6783-3p and upregulates L1CAM for promoting LUSC progression. An RNA-binding protein DDX3X is proposed to modulate LINC02323 expression.

Solitary extramedullary plasmacytoma of the left main bronchus

We report an extremely rare case involving mixed BA/CMPT and AIS in the same tumor. In our case, the AIS component had an EGFR driver mutation in exon 19. No driver mutations were detected in the BA/CMPT component. The tumor boundaries between BA/CMPT and AIS were relatively clear. Driver mutations or malignant transformation in BA/CMPT have been reported in several cases, but the present case, it is thought that the two tumors were incidentally mixed. The malignant potential of BA/CMPT should also be considered.