Chest ultrasound represents an important supplementary technique in the preoperative evaluation of the expansion of malignant pleural diseases. It allows to localize pleural tumors or pleural thickening and guide safe entry site for biopsy of the pleura, to assess the invasion of tumors to the pleura and chest wall, and guide biopsy of the tumors.

• Anti-SARS-CoV-2 messenger RNA vaccination is safe in patients with lung cancer receiving chemotherapy.
• Fever is more common in patients with lung cancer receiving chemotherapy.
• Vaccine-related side effects in these patients are comparable to those observed in healthy individuals.

To explore the efficacy and prognostic factors of different treatment modalities on ALK+ NSCLC patients with brain metastases (BMs), 86 patients were retrospectively divided into two cohorts based on their history of treatment with ALK-TKIs prior to the incidence of BMs. Based on our results, the second-generation ALK- TKIs improved the duration of intracranial response and survival in ALK+ NSCLC patients with BMs in real world. Lower KPS (<80) had a negative impact on clinical outcomes (p < 0.0001) as an independent predictor.

Oncolytic VSV^ΔM51 was recognized by RIG-I and remarkably initiated innate immune responses in several tumor cell lines. RIG-I-mediated innate immune signaling in tumor cells inhibited the replication of VSV^ΔM51 and played a negative role in regulating antitumor therapy with VSV^ΔM51 virus.

METTL14 was significantly highly expressed in lung cancer. By increasing colony stimulating factor 1 receptor (CSF1R) mRNA N6-methyladenosine, METTL14 elevated CSF1R mRNA expression and contributed to lung cancer progression.

The robot-assisted thymectomy (RAT) can be performed using various approaches. The sub-xiphoid approach is routinely selected for centered and advanced large AMTs in our center; it can provide excellent visualization for exposing the proximal and distal ends of the innominate vein, which is convenient for resection of the invaded innominate vein, even for partial resection of the superior vena cava (SVC).

In clinical practice, when two or more distant lung segments or subsegments of the same lobe present with a ground glass opacity, lobectomy is performed in most of these patients. For these particular types of nodules, we perform “separated” precise subsegmentectomy to preserve more lung tissue. “Separated” precise subsegmentectomy is a novel and safe surgical method that could provide a more optimized way for patients with specific multiple nodules to preserve lung function.

What is the best strategy to obtain one-lung ventilation (OLV) in obese patients scheduled for thoracoscopic lung resections? Double lumen tubes (DLTs), (i.e., Carlens tube, Robertshaw tube etc…) or single-lumen tube (SLT) with bronchial blockers (i.e., Univent, EZ blockers etc…)?Obese group compared to the control group was associated with: (i) higher use of a SLT with bronchial blockers than DLT; (ii) longer intubation time; and (iii) higher failure rate of intubation at the first attempt. No significant intergroup difference was found regarding intra-, peri- and postoperative complications and/or mortality.OLV was also safely performed in obese patients, and obesity did not negatively affect surgical outcomes. The preoperative evaluation of patients remains crucial when choosing the best strategy for obtaining OLV.

The consolidation to tumor ratio of volume was the best preoperative pathologically noninvasive predictive factor. Sublobar resection should be performed with caution in cases with significant solid components on three-dimensional images.

The increased survival of patients after a first operation has caused increases in the incidence of locoregional recurrence or second primary lung cancer and a concomitant increase in the number of patients who require secondary surgery. Ipsilateral secondary operation is also commonly practiced, albeit with enhanced difficulty. Therefore, it is necessary to evaluate the feasibility and safety of VATS for ipsilateral lung cancer after pulmonary resection.

Complete hilar lymph node dissection or qualitative diagnosis be performed with curative segmentectomy. In particular, part of the NSCLC in segment 6 patients may be a candidate for lobectomy because of the difficulty of complete dissection of station 11 lymph node.

Our study observed a plausible association between CRF and gut microbiota composition, with increasing proinflammation taxa in severe CRF patients and anti-inflammation taxa growing in mild CRF patients.

Lung adenocarcinoma (LUAD) is the most prevalent histotype of non-small cell lung cancer.

Primary sebaceous carcinoma of the lung is very rare, and no effective treatment has been yet established. We successfully treated lung sebaceous carcinoma with sequential treatment with radiotherapy and anti-PD-1 antibody therapy. The tumor had AKT1 mutation and was positive for PD-L1 expression, suggesting AKT-PD-L1 pathway may be implicated in the response to therapy.