Highlights

• Hyperglycemia results in aberrant expression of several LncRNAs (RNAs with >200 nucleotides), leading to altered expression of many genes and metabolic abnormalities implicated in the development of diabetic retinopathy.
• However, reversal of hyperglycemia by normoglycemia does not provide any benefit to these aberrantly expressed LncRNAs, and the retinopathy continues to progress.

Highlights

• Our study suggests sex differences for visceral fat obesity and cardiac hemodynamic parameters.
• VFA is significantly associated with the development of artery stiffness, left ventricular function and deformation in female patients with T2DM.

Highlights

• T2DM-MCI with higher insulin resistance has more severe hippocampal volume atrophy.
• Hippocampal-prefrontal circuitry dysfunction is observed in T2DM patients.
• Insulin resistance plays a crucial role in T2DM patients with cognitive impairment.

Highlights

• A total of 1640 individuals representing all of the 14 identified MODY subtypes were included.
• MODY accounted for 0.2% of children, adolescents, and adults with diabetes in DPV.
• As of today, not all physicians and individuals with MODY are familiar with current treatment recommendations so far.
• Registries are an important source for representing rare diabetes types and provide a basis for discussing treatment guidelines for individuals with MODY.

Highlights

• This study was the first to explore the association between the longitudinal changes in maternal serum ferritin with GDM.
• We found pregnant women that initially elevated ferritin levels can reduce their risk of GDM by lowering their ferritin levels in later stages of pregnancy.
• Routine iron supplementation may not be suitable for women with sufficient iron levels.

Highlights

• Our results suggested that mass spectrometry was qualitatively, but not quantitatively, reflect the fold changes of proteins in diabetes.
• We revealed that glucose control was unable to rescue hyperglycemia-induced alterations of subcellular proteins in the diabetic heart.
• A potential vicious cycle between dysregulated miRNAs and disordered oxidative phosphorylation provides novel insights into hyperglycemic memory in diabetic cardiomyopathy.

Highlights

• The role of phages in preserving human health and their involvement in the pathogenesis of metabolic diseases.
• The recent advancements in phage-based therapies, and current challenges and potential future directions.