Structural and functional alterations of the hippocampal subfields in T2DM with mild cognitive impairment and insulin resistance: A prospective study
Chen Yang
The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Gansu University of Chinese Medicine, Lanzhou, China
Search for more papers by this authorHuiyan Zhang
School of Clinical Medicine, Ningxia Medical University, Yinchuan, China
Search for more papers by this authorZihan Ma
The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Gansu University of Chinese Medicine, Lanzhou, China
Search for more papers by this authorYanjun Fan
The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Gansu University of Chinese Medicine, Lanzhou, China
Search for more papers by this authorYanan Xu
The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Gansu University of Chinese Medicine, Lanzhou, China
Search for more papers by this authorJian Tan
The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Gansu University of Chinese Medicine, Lanzhou, China
Search for more papers by this authorJing Tian
Department of Radiology, Gansu Provincial Hospital, Lanzhou, China
Search for more papers by this authorJiancang Cao
Department of Radiology, Gansu Provincial Hospital, Lanzhou, China
Search for more papers by this authorWenwen Zhang
Department of Radiology, Gansu Provincial Hospital, Lanzhou, China
Search for more papers by this authorGang Huang
Department of Radiology, Gansu Provincial Hospital, Lanzhou, China
Search for more papers by this authorCorresponding Author
Lianping Zhao
Department of Radiology, Gansu Provincial Hospital, Lanzhou, China
Correspondence
Lianping Zhao, Department of Radiology, Gansu Provincial Hospital, No. 204#, Donggang West Road, Lanzhou 730000, China.
Email: [email protected]
Search for more papers by this authorChen Yang
The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Gansu University of Chinese Medicine, Lanzhou, China
Search for more papers by this authorHuiyan Zhang
School of Clinical Medicine, Ningxia Medical University, Yinchuan, China
Search for more papers by this authorZihan Ma
The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Gansu University of Chinese Medicine, Lanzhou, China
Search for more papers by this authorYanjun Fan
The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Gansu University of Chinese Medicine, Lanzhou, China
Search for more papers by this authorYanan Xu
The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Gansu University of Chinese Medicine, Lanzhou, China
Search for more papers by this authorJian Tan
The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Gansu University of Chinese Medicine, Lanzhou, China
Search for more papers by this authorJing Tian
Department of Radiology, Gansu Provincial Hospital, Lanzhou, China
Search for more papers by this authorJiancang Cao
Department of Radiology, Gansu Provincial Hospital, Lanzhou, China
Search for more papers by this authorWenwen Zhang
Department of Radiology, Gansu Provincial Hospital, Lanzhou, China
Search for more papers by this authorGang Huang
Department of Radiology, Gansu Provincial Hospital, Lanzhou, China
Search for more papers by this authorCorresponding Author
Lianping Zhao
Department of Radiology, Gansu Provincial Hospital, Lanzhou, China
Correspondence
Lianping Zhao, Department of Radiology, Gansu Provincial Hospital, No. 204#, Donggang West Road, Lanzhou 730000, China.
Email: [email protected]
Search for more papers by this authorAbstract
Background
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR) and is often accompanied by mild cognitive impairment (MCI). The detrimental effects of T2DM and IR on the hippocampus have been extensively demonstrated. Few studies have examined the effects of IR on structure and function of hippocampal subfields in T2DM-MCI patients.
Method
A total of 104 T2DM patients were recruited in this prospective study and divided into four groups (T2DM-MCI-higherIR, n = 17; T2DM-MCI-lowerIR, n = 32; T2DM-nonMCI-higherIR, n = 19; T2DM-nonMCI-lowerIR, n = 36). Structure and function MRI data were captured. Clinical variables and neuropsychological scores were determined for all participants. Hippocampal subfield volume and functional connectivity were compared among four groups. Partial correlation analysis was performed between imaging indicators, clinical variables, and neuropsychological scores in all patients.
Results
T2DM-MCI-higher IR group had the smallest volumes of bilateral hippocampal tail, right subiculum-body, right GC-ML-DG-body, and right CA4-body. IR in right hippocampal tail, right subiculum-body, and right GC-ML-DG-body exerted main effect. Furthermore, elevated functional connectivity was found between right subiculum-body and bilateral dorsolateral prefrontal cortex and right anterior cingulate–medial prefrontal cortex. Hippocampal subfield volume positively correlates with total cholesterol and triglycerides and negatively correlates with fasting insulin.
Conclusion
The present study found that T2DM-MCI patients have structural and functional alterations in hippocampal subfields, and IR is a negative factor influencing the alteration of hippocampal subfields volume. These findings support the importance of IR in T2DM-MCI patients and might be potential neuroimaging biomarkers of cerebral impairment in T2DM-MCI patients.
CONFLICT OF INTEREST STATEMENT
The authors declare no conflicts of interest.
Supporting Information
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| jdb70029-sup-0002-Supinfo2.docxWord 2007 document , 14.6 KB | Data S2. Supporting Information. |
| jdb70029-sup-0003-Supinfo3.docxWord 2007 document , 17.3 KB | Data S3. Supporting Information. |
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