Highlights

• This long-term longitudinal study demonstrates the association between alcohol consumption and health outcomes in patients with abnormal glucose metabolism including type 2 diabetes mellitus and prediabetes.
• Occasional drinking (less than once a week) reduces the risk of all-cause mortality, while heavy alcohol consumption (≥30 g/day for men and ≥15 g/day for women) significantly increases the risk of new-onset stroke.
• Patients with abnormal glucose metabolism should avoid heavy alcohol intake, but light alcohol consumption or occasional drinking is acceptable.
• This study provided evidence of lifestyle instructions for patients with abnormal glucose metabolism.

Highlights

• With the increase in the elderly population, diabetic foot ulcers (DFUs) severely affect human health and societies worldwide. They will pose significant medical, social, and socioeconomic challenges.
• Reviewing the existing studies on the pathogenesis of DFUs, most of them focus on clinical nursing and treatment. However, the molecular mechanisms of DFUs are poorly studied.
• The mechanisms of inflammatory response, signal pathway, and epigenetics in DFUs are highlighted.
• The authors suggest reasonable choices of finding out important targets for treatment of disorders of DFUs and developing the effective products underlying the molecular pathogenesis of DFUs.
• Future insights into the use of motor molecules to carry drug molecules in combination with existing materials are briefly discussed.

Highlights

• Different microvascular phenotypes were detected by noninvasive optical coherence tomography angiography (OCTA) in metabolically healthy obesity and metabolic syndrome patients.
• Baseline blood pressure and insulin status may be key determinants for vascular benefit from bariatric surgery.
• OCTA may be a reliable method to study the onset and progression of microvascular complications associated with obesity before and after bariatric surgery.

Highlights

• Leukocyte telomere length was independently associated with the risk of cardiovascular mortality.
• Leukocyte telomere length was not associated with the risk of all-cause mortality in patients with diabetes.
• Telomere length may be a predictor of cardiovascular mortality in diabetes.

Highlights

• The logistic regression model consisted of seven commonly used clinical indicators (including lipid profile) and gestational diabetes mellitus subtypes, with an area under the curve (AUC) of 0.760 for the training set and 0.748 for the internal validation set.
• The two machine learning algorithms large for gestational age prediction models included all the variables, the decision tree prediction model had AUCs of 0.813 and 0.779 for the training set and the internal validation set. The random forest prediction model showed AUCs of 0.854 and 0.808 for the training set and the internal validation set.

Highlights

• This is the first cross-sectional study of the association between serum IGF2BP3 levels and odds of T2DM in high-risk Chinese population.
• Two upregulated (IGF2BP2 and IGF2BP3) and 5 downregulated (METTL3, ALKBH1, YTHDF2, YTHDF3, and HNRNPC) m⁶A-related genes could contribute to the occurrence of T2DM.
• A U-shaped association existed between serum IGF2BP3 levels and odds of T2DM, which highlights diagnostic and prognostic values of serum IGF2BP3 in T2DM risk assessment.