• Issue

    Hepatology: Volume 71, Issue 4

    1143-1526
    April 2020
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Cover Image

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Cover Image

  • First Published: 10 April 2020

Issue Information

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Masthead

  • First Published: 10 April 2020
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Table of contents

  • First Published: 10 April 2020

Hepatology Highlights

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Hepatology Highlights

Kamolyut Lapumnuaypol,  Christopher J. Danford,  Daryl T.Y. Lau,  Joseph F. Pisa,  Robert S. Brown Jr.,  Angel Morales Santiago,  Giorgio Roccaro,  Amaia Navarro-Corcuera,  Robert E. Schwartz,  Enis Kostallari,  Nicholas W. Russo,  Petra Hirsova,  Jessica L. Maiers,  Nidhi Jalan-Sakrikar, 
  • Pages: 1143-1145
  • First Published: 10 April 2020

Editorials

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Timing Is Everything: Improving NASH Histology in Clinical Trials Should Not Be Rushed

Vlad Ratziu M.D., Ph.D., 
  • Pages: 1146-1149
  • First Published: 02 March 2020
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Taming the Savage Breast From Within: Transcription Factor 21, a Regulator of Stellate Cell Deactivation

Shuang Wang Ph.D.,  Scott L. Friedman M.D., 
  • Pages: 1150-1153
  • First Published: 31 January 2020

Original Articles

VIRAL HEPATITIS

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Nuclear Sensor Interferon-Inducible Protein 16 Inhibits the Function of Hepatitis B Virus Covalently Closed Circular DNA by Integrating Innate Immune Activation and Epigenetic Suppression

Yuanyuan Yang,  Xinzhuan Zhao,  Ziyu Wang,  Wangqin Shu,  Lijie Li,  Yuqi Li,  Zhiwei Guo,  Bo Gao,  Sidong Xiong, 
  • Pages: 1154-1169
  • First Published: 12 August 2019
Open Access

Modeling Progress Toward Elimination of Hepatitis B in Australia

Karen McCulloch,  Nicole Romero,  Jennifer MacLachlan,  Nicole Allard,  Benjamin Cowie, 
  • Pages: 1170-1181
  • First Published: 16 August 2019
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Elevated Fatty Liver Index as a Risk Factor for All-Cause Mortality in Human Immunodeficiency Virus–Hepatitis C Virus–Coinfected Patients (ANRS CO13 HEPAVIH Cohort Study)

Tangui Barré,  Camelia Protopopescu,  Firouzé Bani-Sadr,  Lionel Piroth,  Teresa Rojas Rojas,  Dominique Salmon-Ceron,  Linda Wittkop,  Laure Esterle,  Philippe Sogni,  Karine Lacombe,  Julie Chas,  Olivia Zaegel,  Marie-Laure Chaix,  Patrick Miailhes,  Lawrence Serfaty,  Fabienne Marcellin,  Maria Patrizia Carrieri,  ANRS CO13 HEPAVIH Study Group , 
  • Pages: 1182-1197
  • First Published: 29 August 2019

STEATOHEPATITIS/METABOLIC LIVER DISEASE

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NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients With Nonalcoholic Steatohepatitis

Stephen A. Harrison,  Stephen J. Rossi,  Angelo H. Paredes,  James F. Trotter,  Mustafa R. Bashir,  Cynthia D. Guy,  Rajarshi Banerjee,  Mark J. Jaros,  Sandra Owers,  Bryan A. Baxter,  Lei Ling,  Alex M. DePaoli, 
  • Pages: 1198-1212
  • First Published: 25 February 2019
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Lean NAFLD: A Distinct Entity Shaped by Differential Metabolic Adaptation

Fei Chen,  Saeed Esmaili,  Geraint B. Rogers,  Elisabetta Bugianesi,  Salvatore Petta,  Giulio Marchesini,  Ali Bayoumi,  Mayada Metwally,  Mahmoud Karimi Azardaryany,  Sally Coulter,  Jocelyn M. Choo,  Ramy Younes,  Chiara Rosso,  Christopher Liddle,  Leon A. Adams,  Antonio Craxì,  Jacob George,  Mohammed Eslam, 
  • Pages: 1213-1227
  • First Published: 23 August 2019
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hnRNPU/TrkB Defines a Chromatin Accessibility Checkpoint for Liver Injury and Nonalcoholic Steatohepatitis Pathogenesis

Jing Xiong,  Tongyu Liu,  Lin Mi,  Henry Kuang,  Xuelian Xiong,  Zhimin Chen,  Siming Li,  Jiandie D. Lin, 
  • Pages: 1228-1246
  • First Published: 30 August 2019

HEPATOBILIARY MALIGNANCIES

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Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma

Kohei Shigeta,  Meenal Datta,  Tai Hato,  Shuji Kitahara,  Ivy X. Chen,  Aya Matsui,  Hiroto Kikuchi,  Emilie Mamessier,  Shuichi Aoki,  Rakesh R. Ramjiawan,  Hiroki Ochiai,  Nabeel Bardeesy,  Peigen Huang,  Mark Cobbold,  Andrew X. Zhu,  Rakesh K. Jain,  Dan G. Duda, 
  • Pages: 1247-1261
  • First Published: 05 August 2019
Open Access

Mesencephalic Astrocyte-Derived Neurotrophic Factor Inhibits Liver Cancer Through Small Ubiquitin-Related Modifier (SUMO)ylation-Related Suppression of NF-κB/Snail Signaling Pathway and Epithelial-Mesenchymal Transition

Jun Liu,  Zhengsheng Wu,  Dan Han,  Chuansheng Wei,  Yanyan Liang,  Tongcui Jiang,  Lu Chen,  Manqi Sha,  Yajie Cao,  Fan Huang,  Xiaoping Geng,  Jishuang Yu,  Yujun Shen,  Hua Wang,  Lijie Feng,  Dong Wang,  Shengyun Fang,  Siying Wang,  Yuxian Shen, 
  • Pages: 1262-1278
  • First Published: 30 August 2019
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CRAF Methylation by PRMT6 Regulates Aerobic Glycolysis–Driven Hepatocarcinogenesis via ERK-Dependent PKM2 Nuclear Relocalization and Activation

Tin-Lok Wong,  Kai-Yu Ng,  Kel Vin Tan,  Lok-Hei Chan,  Lei Zhou,  Noélia Che,  Ruby L.C. Hoo,  Terence K. Lee,  Stéphane Richard,  Chung-Mau Lo,  Kwan Man,  Pek-Lan Khong,  Stephanie Ma, 
  • Pages: 1279-1296
  • First Published: 30 August 2019

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE

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Immune Exhaustion of T Cells in Alveolar Echinococcosis Patients and Its Reversal by Blocking Checkpoint Receptor TIGIT in a Murine Model

Chuanshan Zhang,  Renyong Lin,  Zhide Li,  Shuting Yang,  Xiaojuan Bi,  Hui Wang,  Abudusalamu Aini,  Ning Zhang,  Abuduaini Abulizi,  Cheng Sun,  Liang Li,  Zhibin Zhao,  Rongde Qin,  Xiaohong Li,  Liang Li,  Tuerganaili Aji,  Yingmei Shao,  Dominique A. Vuitton,  Zhigang Tian,  Hao Wen, 
  • Pages: 1297-1315
  • First Published: 14 August 2019
Open Access

Rotavirus Reassortant–Induced Murine Model of Liver Fibrosis Parallels Human Biliary Atresia

Sujit K. Mohanty,  Inna Lobeck,  Bryan Donnelly,  Phylicia Dupree,  Ashley Walther,  Sarah Mowery,  Abigail Coots,  Alexander Bondoc,  Rachel M. Sheridan,  Holly M. Poling,  Haley Temple,  Monica McNeal,  Karol Sestak,  Ruchi Bansal,  Greg Tiao, 
  • Pages: 1316-1330
  • First Published: 23 August 2019
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Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome

Joshua M. Adams,  Kari A. Huppert,  Eumenia C. Castro,  Mario F. Lopez,  Nima Niknejad,  Sanjay Subramanian,  Neda Zarrin-Khameh,  Milton J. Finegold,  Stacey S. Huppert,  Hamed Jafar-Nejad, 
  • Pages: 1331-1349
  • First Published: 30 August 2019
Open Access

A Bile Duct-on-a-Chip With Organ-Level Functions

Yu Du,  Gauri Khandekar,  Jessica Llewellyn,  William Polacheck,  Christopher S. Chen,  Rebecca G. Wells, 
  • Pages: 1350-1363
  • First Published: 29 August 2019

LIVER FAILURE/CIRRHOSIS/PORTAL HYPERTENSION

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Appraisal of Cardiac Ejection Fraction With Liver Disease Severity: Implication in Post–Liver Transplantation Mortality

Hye-Mee Kwon,  Young-Jin Moon,  Kyeo-Woon Jung,  Yong-Seok Park,  Kyoung-Sun Kim,  In-Gu Jun,  Jun-Gol Song,  Gyu-Sam Hwang, 
  • Pages: 1364-1380
  • First Published: 28 August 2019
Open Access

Mixed Fibrinolytic Phenotypes in Decompensated Cirrhosis and Acute-on-Chronic Liver Failure with Hypofibrinolysis in Those With Complications and Poor Survival

Annabel Blasi,  Vishal C. Patel,  Jelle Adelmeijer,  Sarah Azarian,  Maria Hernandez Tejero,  Andrea Calvo,  Javier Fernández,  William Bernal,  Ton Lisman, 
  • Pages: 1381-1390
  • First Published: 29 August 2019
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Interplay of Liver–Heart Inflammatory Axis and Cannabinoid 2 Receptor Signaling in an Experimental Model of Hepatic Cardiomyopathy

Csaba Matyas,  Katalin Erdelyi,  Eszter Trojnar,  Suxian Zhao,  Zoltan V. Varga,  Janos Paloczi,  Partha Mukhopadhyay,  Balazs T. Nemeth,  György Haskó,  Resat Cinar,  Robim M. Rodrigues,  Yeni Ait Ahmed,  Bin Gao,  Pal Pacher, 
  • Pages: 1391-1407
  • First Published: 30 August 2019
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Near-Infrared Spectroscopy Reveals Brain Hypoxia and Cerebrovascular Dysregulation in Primary Biliary Cholangitis

Chris C. Duszynski,  V. Avati,  A.P. Lapointe,  F. Scholkmann,  J.F. Dunn,  M.G. Swain, 
  • Pages: 1408-1420
  • First Published: 19 September 2019

LIVER INJURY/REGENERATION

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CREBZF as a Key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice

Zhimin Hu,  Yamei Han,  Yuxiao Liu,  Zehua Zhao,  Fengguang Ma,  Aoyuan Cui,  Feifei Zhang,  Zhengshuai Liu,  Yaqian Xue,  Jinyun Bai,  Haifu Wu,  Hua Bian,  Y. Eugene Chin,  Ying Yu,  Zhuoxian Meng,  Hua Wang,  Yong Liu,  Jiangao Fan,  Xin Gao,  Yan Chen,  Yu Li, 
  • Pages: 1421-1436
  • First Published: 30 August 2019

LIVER BIOLOGY/PATHOBIOLOGY

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A Deactivation Factor of Fibrogenic Hepatic Stellate Cells Induces Regression of Liver Fibrosis in Mice

Yasuhiro Nakano,  Akihide Kamiya,  Hideaki Sumiyoshi,  Kota Tsuruya,  Tatehiro Kagawa,  Yutaka Inagaki, 
  • Pages: 1437-1452
  • First Published: 24 September 2019
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Vitamin D Receptor Activation in Liver Macrophages Protects Against Hepatic Endoplasmic Reticulum Stress in Mice

Ying Zhou,  Bingning Dong,  Kang Ho Kim,  Sungwoo Choi,  Zhen Sun,  Nan Wu,  Yifan Wu,  Jessica Scott,  David D. Moore, 
  • Pages: 1453-1466
  • First Published: 05 August 2019

Concise Review

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A Single-Cell Perspective of the Mammalian Liver in Health and Disease

Xuelian Xiong,  Henry Kuang,  Tongyu Liu,  Jiandie D. Lin, 
  • Pages: 1467-1473
  • First Published: 30 January 2020

Reviews

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Liver Diseases in the Perinatal Period: Interactions Between Mother and Infant

Samar H. Ibrahim,  Maureen M. Jonas,  Sarah A. Taylor,  Luz Helena Gutierrez Sanchez,  Jaqueline L. Wolf,  Shikha S. Sundaram, 
  • Pages: 1474-1485
  • First Published: 10 January 2020
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New Insights Into Intestinal Failure–Associated Liver Disease in Children

Racha T. Khalaf,  Ronald J. Sokol, 
  • Pages: 1486-1498
  • First Published: 31 January 2020

Hepatology Elsewhere

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Ceramides: A Cause of Insulin Resistance in Nonalcoholic Fatty Liver Disease in Both Murine Models and Humans

Hannele Yki-Järvinen M.D., F.R.C.P., 
  • Pages: 1499-1501
  • First Published: 03 January 2020
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Small but Mighty: Platelets in NASH and Other Chronic Liver Diseases

Moira B. Hilscher M.D.,  Vijay H. Shah M.D., 
  • Pages: 1501-1504
  • First Published: 05 January 2020
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Transcriptomic Traces of Adult Human Liver Progenitor Cells

Simone N.T. Kurial B.Sc.,  Holger Willenbring M.D., Ph.D., 
  • Pages: 1504-1507
  • First Published: 28 January 2020

Clinical Observations In Hepatology

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Post–Liver Transplantation Sinusoidal Obstruction Syndrome With Refractory Ascites Induced by Mycophenolate Mofetil

Edoardo Poli,  Ilias Kounis,  Catherine Guettier,  Céline Verstuyft,  Audrey Coilly,  Rodolphe Sobesky,  Cyrille Feray,  Eric Vibert,  Oriana Ciacio,  Didier Samuel,  Henri Bismuth,  Jean-Charles Duclos-Vallée, 
  • Pages: 1508-1510
  • First Published: 09 October 2019
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Liver Injury in Patients With Cholestatic Liver Disease Treated With Obeticholic Acid

John E. Eaton,  Raj Vuppalanchi,  Rajender Reddy,  Sanjaya K. Satapathy,  Bilal Ali,  Patrick S. Kamath, 
  • Pages: 1511-1514
  • First Published: 04 November 2019

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A Cautionary Report of Doxycycline-Induced Autoimmune Hepatitis

Ali Fakhreddine,  Catherine Frenette, 
  • Pages: 1515-1517
  • First Published: 07 November 2019

Correspondence

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Letter to the Editor: Hip Fracture Risk in Patients With Cirrhosis: Does Diabetes Mellitus Matter?

Shih-Wei Lai,  Cheng-Li Lin, 
  • Pages: 1518-1519
  • First Published: 14 February 2019
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Reply

Mindie H. Nguyen M.D., M.A.S., 
  • Page: 1519
  • First Published: 14 February 2019
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Letter to the Editor: Abdominal Surgery in Idiopathic Noncirrhotic Portal Hypertension: Is Preemptive TIPS Reducing Postoperative Complications?

Emanuele Felli,  Antonio Saviano,  Simona Tripon,  Thomas F. Baumert,  Patrick Pessaux, 
  • Pages: 1520-1522
  • First Published: 09 October 2019
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Letter to the Editor: Glomerular Filtration Rate Assessment in Liver Disease (GRAIL): Are We There Yet?

Joana Carvão M.D.,  Luís Jasmins M.D., 
  • Pages: 1522-1523
  • First Published: 26 October 2019
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Reply:

Sumeet K. Asrani M.D., M.Sc., 
  • Page: 1523
  • First Published: 25 October 2019
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Letter to the Editor: Glucocorticosteroids for Alcohol-Associated Hepatitis

Daria L. Varganova M.D., Ph.D. Student,  Chavdar S. Pavlov M.D., Ph.D.,  Giovanni Casazza Ph.D.,  Dimitrinka Nikolova M.A.,  Christian Gluud M.D., Ph.D., Dr.Med.Sci., 
  • Page: 1524
  • First Published: 29 October 2019
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Letter to the Editor: Modest Alcohol Consumption and Nonalcoholic Fatty Liver Disease: An Oxymoron?

Alain Braillon M.D., Ph.D., 
  • Page: 1525
  • First Published: 04 November 2019
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Reply:

Kaveh Hajifathalian M.D.,  Babak Torabi Sagvand M.D.,  Arthur McCullough M.D., 
  • Page: 1526
  • First Published: 04 November 2019

Issue Information

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Notices

  • First Published: 10 April 2020
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Instructions to Authors

  • First Published: 10 April 2020