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    Hepatology: Volume 71, Issue 3

    771-1141
    March 2020
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Cover Image

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Cover Image

  • First Published: 22 March 2020

Issue Information

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Masthead

  • First Published: 22 March 2020
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Table of contents

  • First Published: 22 March 2020

Hepatology Highlights

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Hepatology Highlights

Nidhi Jalan-Sakrikar,  Robert E. Schwartz,  Muhammad Amir,  Joel Wedd,  Joseph F. Pisa,  Robert S. Brown Jr.,  Nicholas W. Russo,  Ravi S. Vora,  Alyson Kaplan,  Russell Rosenblatt,  Amaia Navarro-Corcuera,  Enis Kostallari,  Petra Hirsova, 
  • Pages: 771-773
  • First Published: 22 March 2020

Editorials

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NAFLD-Related Hepatocellular Carcinoma and the Four Horsemen of the Apocalypse

Jose D. Debes M.D.,  Andre Boonstra Ph.D.,  Robert J. de Knegt M.D., 
  • Pages: 774-776
  • First Published: 10 February 2020
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PNPLA3 Genotype and Risk of Liver and All-Cause Mortality

Stefan Stender M.D., Ph.D.,  Rohit Loomba M.D., M.HSc., 
  • Pages: 777-779
  • First Published: 18 January 2020

Original Articles

VIRAL HEPATITIS

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Hepatitis C Virus Mediated Inhibition of miR-181c Activates ATM Signaling and Promotes Hepatocyte Growth

Tapas Patra,  Keith Meyer,  Ratna B. Ray,  Ranjit Ray, 
  • Pages: 780-793
  • First Published: 10 August 2019
Open Access

Use of an Outbred Rat Hepacivirus Challenge Model for Design and Evaluation of Efficacy of Different Immunization Strategies for Hepatitis C Virus

Erwan Atcheson,  Wenqin Li,  Carly M. Bliss,  Senthil Chinnakannan,  Kathrin Heim,  Hannah Sharpe,  Claire Hutchings,  Isabelle Dietrich,  Dung Nguyen,  Amit Kapoor,  Michael A. Jarvis,  Paul Klenerman,  Eleanor Barnes,  Peter Simmonds, 
  • Pages: 794-807
  • First Published: 10 August 2019

STEATOHEPATITIS/METABOLIC LIVER DISEASE

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Effect of Metabolic Traits on the Risk of Cirrhosis and Hepatocellular Cancer in Nonalcoholic Fatty Liver Disease

Fasiha Kanwal,  Jennifer R. Kramer,  Liang Li,  Jianliang Dai,  Yamini Natarajan,  Xian Yu,  Steven M. Asch,  Hashem B. El-Serag, 
  • Pages: 808-819
  • First Published: 01 November 2019
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Patatin-Like Phospholipase Domain-Containing Protein 3 I148M and Liver Fat and Fibrosis Scores Predict Liver Disease Mortality in the U.S. Population

Aynur Unalp-Arida,  Constance E. Ruhl, 
  • Pages: 820-834
  • First Published: 09 November 2019
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Risks of Light and Moderate Alcohol Use in Fatty Liver Disease: Follow-Up of Population Cohorts

Fredrik Åberg,  Pauli Puukka,  Veikko Salomaa,  Satu Männistö,  Annamari Lundqvist,  Liisa Valsta,  Markus Perola,  Martti Färkkilä,  Antti Jula, 
  • Pages: 835-848
  • First Published: 19 July 2019
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Clinical Utility of an Increase in Magnetic Resonance Elastography in Predicting Fibrosis Progression in Nonalcoholic Fatty Liver Disease

Veeral H. Ajmera,  Amy Liu,  Seema Singh,  Georg Yachoa,  Matthew Ramey,  Meera Bhargava,  Ava Zamani,  Scarlett Lopez,  Neeraj Mangla,  Ricki Bettencourt,  Emily Rizo,  Mark Valasek,  Cynthia Behling,  Lisa Richards,  Claude Sirlin,  Rohit Loomba, 
  • Pages: 849-860
  • First Published: 25 September 2019
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Low Levels of Alcohol Consumption, Obesity, and Development of Fatty Liver With and Without Evidence of Advanced Fibrosis

Yoosoo Chang,  Seungho Ryu,  Yejin Kim,  Yong Kyun Cho,  Eunju Sung,  Han-Na Kim,  Jiin Ahn,  Hyun-Suk Jung,  Kyung Eun Yun,  Seolhye Kim,  Ki-Chul Sung,  Chong Il Sohn,  Hocheol Shin,  Sarah H. Wild,  Christopher D. Byrne, 
  • Pages: 861-873
  • First Published: 19 July 2019
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Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease

Francesco De Chiara,  Karen Louise Thomsen,  Abeba Habtesion,  Helen Jones,  Nathan Davies,  Jordi Gracia-Sancho,  Nicolò Manicardi,  Andrew Hall,  Fausto Andreola,  Hannah L. Paish,  Lee H. Reed,  Abigail A. Watson,  Jack Leslie,  Fiona Oakley,  Krista Rombouts,  Rajeshwar Prosad Mookerjee,  Jelena Mann,  Rajiv Jalan, 
  • Pages: 874-892
  • First Published: 05 August 2019

HEPATOBILIARY MALIGNANCIES

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Characterization of Gut Microbiota, Bile Acid Metabolism, and Cytokines in Intrahepatic Cholangiocarcinoma

Xiaodong Jia,  Shanshan Lu,  Zhen Zeng,  Qingyan Liu,  Zheng Dong,  Yan Chen,  Zhenyu Zhu,  Zhixian Hong,  Ting Zhang,  Guifang Du,  Jiao Xiang,  Dawei Wu,  Wenlin Bai,  Bin Yang,  Yinyin Li,  Jiagan Huang,  Haiyang Li,  Rifaat Safadi,  Yinying Lu, 
  • Pages: 893-906
  • First Published: 12 July 2019
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Diabetes Is Associated With Increased Risk of Hepatocellular Carcinoma in Patients With Cirrhosis From Nonalcoholic Fatty Liver Disease

Ju Dong Yang,  Fowsiyo Ahmed,  Kristin C. Mara,  Benyam D. Addissie,  Alina M. Allen,  Gregory J. Gores,  Lewis R. Roberts, 
  • Pages: 907-916
  • First Published: 15 July 2019
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A Metallomic Approach to Assess Associations of Serum Metal Levels With Gallstones and Gallbladder Cancer

Mei-Hsuan Lee,  Yu-Tang Gao,  Yu-Han Huang,  Emma E. McGee,  Tram Lam,  Bingsheng Wang,  Ming-Chang Shen,  Asif Rashid,  Ruth M. Pfeiffer,  Ann W. Hsing,  Jill Koshiol, 
  • Pages: 917-928
  • First Published: 18 July 2019
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The Mutational Features of Aristolochic Acid–Induced Mouse and Human Liver Cancers

Zhao-Ning Lu,  Qing Luo,  Li-Nan Zhao,  Yi Shi,  Na Wang,  Lan Wang,  Ze-Guang Han, 
  • Pages: 929-942
  • First Published: 20 July 2019
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National Experience on Down-Staging of Hepatocellular Carcinoma Before Liver Transplant: Influence of Tumor Burden, Alpha-Fetoprotein, and Wait Time

Neil Mehta,  Jennifer L. Dodge,  Joshua D. Grab,  Francis Y. Yao, 
  • Pages: 943-954
  • First Published: 25 July 2019
Open Access

4-1BB Delineates Distinct Activation Status of Exhausted Tumor-Infiltrating CD8+ T Cells in Hepatocellular Carcinoma

Hyung-Don Kim,  Seongyeol Park,  Seongju Jeong,  Yong Joon Lee,  Hoyoung Lee,  Chang Gon Kim,  Kyung Hwan Kim,  Seung-Mo Hong,  Jung-Yun Lee,  Sunghoon Kim,  Hong Kwan Kim,  Byung Soh Min,  Jong Hee Chang,  Young Seok Ju,  Eui-Cheol Shin,  Gi-Won Song,  Shin Hwang,  Su-Hyung Park, 
  • Pages: 955-971
  • First Published: 28 July 2019

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE

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Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis

Guido Carpino,  Lorenzo Nevi,  Diletta Overi,  Vincenzo Cardinale,  Wei-Yu Lu,  Sabina Di Matteo,  Samira Safarikia,  Pasquale Bartolomeo Berloco,  Rosanna Venere,  Paolo Onori,  Antonio Franchitto,  Stuart J. Forbes,  Domenico Alvaro,  Eugenio Gaudio, 
  • Pages: 972-989
  • First Published: 22 July 2019
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Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis

Konstantina Kyritsi,  Lixian Chen,  April O’Brien,  Heather Francis,  Travis W. Hein,  Julie Venter,  Nan Wu,  Ludovica Ceci,  Tianhao Zhou,  David Zawieja,  Anatoliy A. Gashev,  Fanyin Meng,  Pietro Invernizzi,  Luca Fabris,  Chaodong Wu,  Nicholas J. Skill,  Romil Saxena,  Suthat Liangpunsakul,  Gianfranco Alpini,  Shannon S. Glaser, 
  • Pages: 990-1008
  • First Published: 25 July 2019

LIVER FAILURE/CIRRHOSIS/PORTAL HYPERTENSION

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Incidence, Risk Factors, and Outcomes of Transition of Acute Kidney Injury to Chronic Kidney Disease in Cirrhosis: A Prospective Cohort Study

Rakhi Maiwall,  Samba Siva Rao Pasupuleti,  Chhagan Bihari,  Archana Rastogi,  Pawan Kumar Singh,  Vini Naik,  Akanksha Singh,  Priyanka Jain,  Awinash Kumar,  Amar Mukund,  R.P. Mathur,  Guresh Kumar,  Shiv Kumar Sarin, 
  • Pages: 1009-1022
  • First Published: 16 July 2019
Open Access

Changes in Hepatic Venous Pressure Gradient Predict Hepatic Decompensation in Patients Who Achieved Sustained Virologic Response to Interferon-Free Therapy

Mattias Mandorfer,  Karin Kozbial,  Philipp Schwabl,  David Chromy,  Georg Semmler,  Albert F. Stättermayer,  Matthias Pinter,  Virginia Hernández-Gea,  Monika Fritzer-Szekeres,  Petra Steindl-Munda,  Michael Trauner,  Markus Peck-Radosavljevic,  Juan C. García-Pagán,  Peter Ferenci,  Thomas Reiberger, 
  • Pages: 1023-1036
  • First Published: 31 July 2019

LIVER INJURY/REGENERATION

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Six-Transmembrane Epithelial Antigen of the Prostate 3 Deficiency in Hepatocytes Protects the Liver Against Ischemia-Reperfusion Injury by Suppressing Transforming Growth Factor-β-Activated Kinase 1

Wen-Zhi Guo,  Hong-Bo Fang,  Sheng-Li Cao,  San-Yang Chen,  Jie Li,  Ji-Hua Shi,  Hong-Wei Tang,  Yi Zhang,  Pei-Hao Wen,  Jia-Kai Zhang,  Zhi-Hui Wang,  Xiao-Yi Shi,  Chun Pang,  Han Yang,  Bo-Wen Hu,  Shui-Jun Zhang, 
  • Pages: 1037-1054
  • First Published: 08 August 2019

LIVER BIOLOGY/PATHOBIOLOGY

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Methyl-Sensing Nuclear Receptor Liver Receptor Homolog-1 Regulates Mitochondrial Function in Mouse Hepatocytes

Sungwoo Choi,  Bingning Dong,  Chih-Chun Janet Lin,  Mi Jeong Heo,  Kang Ho Kim,  Zhen Sun,  Martin Wagner,  Nagireddy Putluri,  Jae Myoung Suh,  Meng C. Wang,  David D. Moore, 
  • Pages: 1055-1069
  • First Published: 29 July 2019

Special Article

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Guidance for Design and Endpoints of Clinical Trials in Chronic Hepatitis B—Report From the 2019 EASL-AASLD HBV Treatment Endpoints Conference

Markus Cornberg,  Anna Suk-Fong Lok,  Norah A. Terrault,  Fabien Zoulim,  the 2019 EASL-AASLD HBV Treatment Endpoints Conference Faculty , 
  • Pages: 1070-1092
  • First Published: 12 November 2019

Reviews

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Applying Machine Learning in Liver Disease and Transplantation: A Comprehensive Review

Ashley Spann,  Angeline Yasodhara,  Justin Kang,  Kymberly Watt,  Bo Wang,  Anna Goldenberg,  Mamatha Bhat, 
  • Pages: 1093-1105
  • First Published: 06 January 2020
Open Access

Nursing Care of Patients With Cirrhosis: The LiverHope Nursing Project

Núria Fabrellas,  Marta Carol,  Ester Palacio,  Marites Aban,  Tommaso Lanzillotti,  Gea Nicolao,  Maria Teresa Chiappa,  Vanessa Esnault,  Sabine Graf-Dirmeier,  Jeltje Helder,  Andrea Gossard,  Mireia Lopez,  Marta Cervera,  Lacey L. Dols,  on behalf of the LiverHope Consortium Investigators , 
  • Pages: 1106-1116
  • First Published: 16 January 2020

Hepatology Elsewhere

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The Two Faces of Relaxin in Cancer: Antitumor or Protumor?

Sumera Rizvi M.D.,  Gregory J. Gores M.D., 
  • Pages: 1117-1119
  • First Published: 20 October 2019
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Something Wicked this Way Comes

Timucin Taner M.D., Ph.D.,  Julie K. Heimbach M.D., 
  • Pages: 1119-1121
  • First Published: 04 November 2019

Clinical Observations in Hepatology

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Acute Liver Failure From Exertional Heatstroke Can Result in Excellent Long-Term Survival With Liver Transplantation

Xia Bi,  Adam Deising,  Catherine Frenette, 
  • Pages: 1122-1123
  • First Published: 11 September 2019
Open Access

Highly Elevated Plasma γ-Glutamyltransferase Elevations: A Trait Caused by γ-Glutamyltransferase 1 Transmembrane Mutations

Alessandro De Grandi,  Maria Franzini,  Štefan Rosipal,  Rastislav Rosipal,  Marianna Debreova,  Alessandro Corti,  Elisabeth Ruetzler-Dichtl,  Sabine Scholl-Bürgi,  Aldo Paolicchi,  Alfonso Pompella,  Michele Emdin,  Germano Zampa,  Heiko Witt,  Heinz Zoller,  Herbert Tilg,  Ertan Mayatepek,  Diran Herebian,  Peter P. Pramstaller,  Thomas Müller,  Andreas R. Janecke, 
  • Pages: 1124-1127
  • First Published: 13 September 2019

Correspondence

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Letter to the Editor: Intrahepatic Lipid Content After Insulin Glargine Addition to Metformin in Type II Diabetes Mellitus With Nonalcoholic Fatty Liver Disease

Vikas Taneja M.D., 
  • Page: 1128
  • First Published: 14 October 2019
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Reply:

Daizhi Yang M.D., Ph.D.,  Jinhua Yan M.D., Ph.D.,  Jianping Weng M.D., Ph.D., 
  • Page: 1129
  • First Published: 15 October 2019
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Letter to the Editor: Is Aristolochic Acid the Major Cause of Liver Cancer in China and Asia?

Jia-bo Wang Ph.D.,  Zhao-fang Bai Ph.D.,  Xiao-he Xiao Ph.D., 
  • Page: 1130
  • First Published: 14 October 2019
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Reply:

Zhao-Ning Lu Ph.D.,  Ze-Guang Han M.D., Ph.D., 
  • Pages: 1130-1131
  • First Published: 14 October 2019
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Letter to the Editor: Bone Health and Denosumab Treatment in Autoimmune Liver Diseases: A Possible Involvement of Physical Activity

Toshihiro Sugiyama M.D., Ph.D., 
  • Pages: 1131-1132
  • First Published: 20 October 2019
Open Access

Reply:

Yoshitaka Arase M.D., Ph.D.,  Tatehiro Kagawa M.D., Ph.D., 
  • Pages: 1132-1133
  • First Published: 19 October 2019
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Letter to the Editor: Could Variceal Screening Stratified by Liver/Spleen Stiffness Replace the Role of Endoscopy?

Gin-Ho Lo M.D., 
  • Page: 1133
  • First Published: 25 October 2019
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Reply:

Grace Lai-Hung Wong M.D.,  Vincent Wai-Sun Wong M.B.Ch.B.(Hons), M.D., F.R.C.P., F.H.K.C.P., F.H.K.A.M., 
  • Page: 1134
  • First Published: 26 October 2019

Obituary

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Kurt J. Isselbacher, M.D., Remembered (1925-2019)

Jules L. Dienstag M.D., 
  • Pages: 1135-1139
  • First Published: 23 January 2020

Corrections

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Correction

  • Page: 1140
  • First Published: 07 February 2020

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Correction

  • Page: 1141
  • First Published: 12 February 2020

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Correction

  • Page: 1141
  • First Published: 22 March 2020

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Correction

  • Page: 1141
  • First Published: 22 March 2020

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Correction

  • Page: 1141
  • First Published: 22 March 2020

Issue Information

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Notices

  • First Published: 22 March 2020
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Instructions to Authors

  • First Published: 22 March 2020