• Issue

    Hepatology: Volume 65, Issue 1

    1-397
    January 2017
Previous Issue|Next Issue
Export Citation(s)Download PDF(s)

Issue Information

Free Access

Masthead

  • First Published: 27 December 2016
Free Access

Table of contents

  • First Published: 27 December 2016

Hepatology Highlights

Free Access

Hepatology Highlights

Jean-François Dufour, 
  • Pages: 1-3
  • First Published: 27 December 2016

Editorials

Free Access

Nonalcoholic steatohepatitis in nonobese patients: Not so different after all

Kenneth Cusi M.D., F.A.C.P., F.A.C.E., 
  • Pages: 4-7
  • First Published: 20 September 2016
Free Access

Serum biomarkers for nonalcoholic fatty liver disease: Are we there yet?

Ken Liu M.B.B.S., F.R.A.C.P.,  Weiqi Xu M.Med.,  Vincent Wai-Sun Wong M.D., 
  • Pages: 8-11
  • First Published: 17 September 2016
Free Access

Silencing sirtuins: A novel way to thwart reperfusion injury?

Pieter Borger Ph.D.,  Pierre-Alain Clavien M.D., Ph.D., 
  • Pages: 12-14
  • First Published: 15 September 2016
Free Access

An ectopically expressed serum miRNA signature is prognostic, diagnostic, and biologically related to liver allograft rejection

James F. Trotter M.D., 
  • Pages: 15-17
  • First Published: 03 November 2016

Viral Hepatitis

Free Access

CD14+ monocyte-derived galectin-9 induces natural killer cell cytotoxicity in chronic hepatitis C

Akira Nishio,  Tomohide Tatsumi,  Takatoshi Nawa,  Takahiro Suda,  Teppei Yoshioka,  Yoshiki Onishi,  Satoshi Aono,  Minoru Shigekawa,  Hayato Hikita,  Ryotaro Sakamori,  Daisuke Okuzaki,  Takasuke Fukuhara,  Yoshiharu Matsuura,  Naoki Hiramatsu,  Tetsuo Takehara, 
  • Pages: 18-31
  • First Published: 19 September 2016
Open Access

Expression of scavenger receptor-AI promotes alternative activation of murine macrophages to limit hepatic inflammation and fibrosis

Adam C. Labonte,  Sun-Sang J. Sung,  Lucas T. Jennelle,  Aditya P. Dandekar,  Young S. Hahn, 
  • Pages: 32-43
  • First Published: 22 October 2016
Free Access

Uptake of hepatitis C screening, characteristics of patients tested, and intervention costs in the BEST-C study

Joanne E. Brady,  Danielle K. Liffmann,  Anthony Yartel,  Natalie Kil,  Alex D. Federman,  Joseph Kannry,  Cynthia Jordan,  Omar I. Massoud,  David R. Nerenz,  Kimberly A. Brown,  Bryce D. Smith,  Claudia Vellozzi,  David B. Rein, 
  • Pages: 44-53
  • First Published: 22 October 2016

Steatohepatitis/Metabolic Liver Disease

Free Access

Histological severity and clinical outcomes of nonalcoholic fatty liver disease in nonobese patients

Jonathan Chung-Fai Leung,  Thomson Chi-Wang Loong,  Jeremy Lok Wei,  Grace Lai-Hung Wong,  Anthony Wing-Hung Chan,  Paul Cheung-Lung Choi,  Sally She-Ting Shu,  Angel Mei-Ling Chim,  Henry Lik-Yuen Chan,  Vincent Wai-Sun Wong, 
  • Pages: 54-64
  • First Published: 23 June 2016
Free Access

Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease

Veeral Ajmera,  Emily R. Perito,  Nathan M. Bass,  Norah A. Terrault,  Katherine P. Yates,  Ryan Gill,  Rohit Loomba,  Anna Mae Diehl,  Bradley E. Aouizerat,  for the NASH Clinical Research Network , 
  • Pages: 65-77
  • First Published: 17 August 2016
Open Access

Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood

Martin L. Decaris,  Kelvin W. Li,  Claire L. Emson,  Michelle Gatmaitan,  Shanshan Liu,  Yenny Wang,  Edna Nyangau,  Marc Colangelo,  Thomas E. Angel,  Carine Beysen,  Jeffrey Cui,  Carolyn Hernandez,  Len Lazaro,  David A. Brenner,  Scott M. Turner,  Marc K. Hellerstein,  Rohit Loomba, 
  • Pages: 78-88
  • First Published: 05 October 2016

Hepatobiliary Malignancies

Free Access

IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice

Juri Bergmann,  Miryam Müller,  Niklas Baumann,  Manuel Reichert,  Carola Heneweer,  Julia Bolik,  Karsten Lücke,  Sabine Gruber,  Antonella Carambia,  Susanne Boretius,  Ivo Leuschner,  Thomas Becker,  Björn Rabe,  Johannes Herkel,  F. Thomas Wunderlich,  Hans-Willi Mittrücker,  Stefan Rose-John,  Dirk Schmidt-Arras, 
  • Pages: 89-103
  • First Published: 22 October 2016
Free Access

Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups

Pavel Sumazin,  Yidong Chen,  Lisa R. Treviño,  Stephen F. Sarabia,  Oliver A. Hampton,  Kayuri Patel,  Toni-Ann Mistretta,  Barry Zorman,  Patrick Thompson,  Andras Heczey,  Sarah Comerford,  David A. Wheeler,  Murali Chintagumpala,  Rebecka Meyers,  Dinesh Rakheja,  Milton J. Finegold,  Gail Tomlinson,  D. Williams Parsons,  Dolores López-Terrada, 
  • Pages: 104-121
  • First Published: 24 October 2016
Free Access

Survival and cost-effectiveness of sorafenib therapy in advanced hepatocellular carcinoma: An analysis of the SEER–Medicare database

Neehar D. Parikh,  Vincent D. Marshall,  Amit G. Singal,  Hari Nathan,  Anna S. Lok,  Rajesh Balkrishnan,  Vahakn Shahinian, 
  • Pages: 122-133
  • First Published: 22 October 2016
Free Access

Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations

Shizhong Ke,  Shuzhen Chen,  Zihui Dong,  Christopher S. Hong,  Qi Zhang,  Liang Tang,  Pinghua Yang,  Jian Zhai,  Hexin Yan,  Feng Shen,  Zhengping Zhuang,  Wen Wen,  Hongyang Wang, 
  • Pages: 134-151
  • First Published: 24 October 2016

Autoimmune, Cholestatic and Biliary Disease

Free Access

Large-scale characterization study of patients with antimitochondrial antibodies but nonestablished primary biliary cholangitis

Géraldine Dahlqvist,  Farid Gaouar,  Fabrice Carrat,  Sofia Meurisse,  Olivier Chazouillères,  Raoul Poupon,  Catherine Johanet,  Christophe Corpechot,  the French network of Immunology Laboratories , 
  • Pages: 152-163
  • First Published: 30 September 2016
Free Access

MYO5B mutations cause cholestasis with normal serum gamma-glutamyl transferase activity in children without microvillous inclusion disease

Emmanuel Gonzales,  Sarah A. Taylor,  Anne Davit-Spraul,  Alice Thébaut,  Nadège Thomassin,  Catherine Guettier,  Peter F. Whitington,  Emmanuel Jacquemin, 
  • Pages: 164-173
  • First Published: 17 August 2016
Free Access

The dendritic cell–T helper 17–macrophage axis controls cholangiocyte injury and disease progression in murine and human biliary atresia

Celine S. Lages,  Julia Simmons,  Avery Maddox,  Keaton Jones,  Rebekah Karns,  Rachel Sheridan,  Shiva Kumar Shanmukhappa,  Sujit Mohanty,  Matthew Kofron,  Pierre Russo,  Yui-Hsi Wang,  Claire Chougnet,  Alexander G. Miethke, 
  • Pages: 174-188
  • First Published: 19 September 2016

Liver Failure/Cirrhosis/Portal Hypertension

Free Access

Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart

Moreshwar S. Desai,  Bhoomika Mathur,  Zeena Eblimit,  Hernan Vasquez,  Heinrich Taegtmeyer,  Saul J. Karpen,  Daniel J. Penny,  David D. Moore,  Sayeepriyadarshini Anakk, 
  • Pages: 189-201
  • First Published: 24 October 2016
Free Access

Polymorphisms in the IL-1 gene cluster influence systemic inflammation in patients at risk for acute-on-chronic liver failure

José Alcaraz-Quiles,  Esther Titos,  Mireia Casulleras,  Marco Pavesi,  Cristina López-Vicario,  Bibiana Rius,  Aritz Lopategi,  Andrea de Gottardi,  Ivo Graziadei,  Henning Gronbaek,  Pere Ginès,  Mauro Bernardi,  Vicente Arroyo,  Joan Clària, 
  • Pages: 202-216
  • First Published: 24 October 2016
Free Access

A Karnofsky performance status–based score predicts death after hospital discharge in patients with cirrhosis

Puneeta Tandon,  K. Rajender Reddy,  Jacqueline G. O'Leary,  Guadalupe Garcia-Tsao,  Juan G. Abraldes,  Florence Wong,  Scott W. Biggins,  Benedict Maliakkal,  Michael B. Fallon,  Ram M. Subramanian,  Paul Thuluvath,  Patrick S. Kamath,  Leroy R. Thacker,  Jasmohan S. Bajaj,  North American Consortium for the Study of End-Stage Liver Disease , 
  • Pages: 217-224
  • First Published: 24 October 2016

Liver Injury/Regeneration

Open Access

Sirtuin 2 aggravates postischemic liver injury by deacetylating mitogen-activated protein kinase phosphatase-1

Jie Wang,  Hyoung-Won Koh,  Lu Zhou,  Ui-Jin Bae,  Hwa-Suk Lee,  In Hyuk Bang,  Sun-O Ka,  Seon-Hee Oh,  Eun Ju Bae,  Byung-Hyun Park, 
  • Pages: 225-236
  • First Published: 17 August 2016
Free Access

Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum

Xuehua Piao,  Soh Yamazaki,  Sachiko Komazawa-Sakon,  Sanae Miyake,  Osamu Nakabayashi,  Takeyuki Kurosawa,  Tetsuo Mikami,  Minoru Tanaka,  Nico Van Rooijen,  Masaki Ohmuraya,  Akira Oikawa,  Yuko Kojima,  Soichiro Kakuta,  Yasuo Uchiyama,  Masato Tanaka,  Hiroyasu Nakano, 
  • Pages: 237-252
  • First Published: 22 October 2016

THIS ARTICLE HAS BEEN RETRACTED

Free Access

Retracted: Redox-dependent regulation of hepatocyte absent in melanoma 2 inflammasome activation in sterile liver injury in mice

Qian Sun,  Patricia Loughran,  Richard Shapiro,  Indira H. Shrivastava,  Daniel J. Antoine,  Tunliang Li,  Zhengzheng Yan,  Jie Fan,  Timothy R. Billiar,  Melanie J. Scott, 
  • Pages: 253-268
  • First Published: 24 October 2016

Liver Biology/Pathobiology

Free Access

An ectopically expressed serum miRNA signature is prognostic, diagnostic, and biologically related to liver allograft rejection

Abraham Shaked,  Bao-Li Chang,  Michael R. Barnes,  Peter Sayre,  Yun R. Li,  Smita Asare,  Michele DesMarais,  Michael V. Holmes,  Toumy Guettouche,  Brendan J. Keating, 
  • Pages: 269-280
  • First Published: 17 August 2016
Free Access

Pivotal role of glutamine synthetase in ammonia detoxification

Theodorus B.M. Hakvoort,  Youji He,  Wim Kulik,  Jacqueline L.M. Vermeulen,  Suzanne Duijst,  Jan M. Ruijter,  Jurgen H. Runge,  Nicolaas E.P. Deutz,  S. Eleonore Koehler,  Wouter H. Lamers, 
  • Pages: 281-293
  • First Published: 19 September 2016
Open Access

Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: A new step in migration

Daniel A. Patten,  Garrick K. Wilson,  Dalan Bailey,  Robert K. Shaw,  Sirpa Jalkanen,  Marko Salmi,  Antal Rot,  Chris J. Weston,  David H. Adams,  Shishir Shetty, 
  • Pages: 294-309
  • First Published: 22 October 2016

Practice Guidance

Free Access

Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases

Guadalupe Garcia-Tsao,  Juan G. Abraldes,  Annalisa Berzigotti,  Jaime Bosch, 
  • Pages: 310-335
  • First Published: 27 October 2016

Special Articles

Free Access

Workforce in hepatology: Update and a critical need for more information

Mark W. Russo,  Ayman A. Koteish,  Michael Fuchs,  K. Gautham Reddy,  Oren K. Fix, 
  • Pages: 336-340
  • First Published: 15 September 2016
Free Access

“Hep C, where art thou”: What are the remaining (fundable) questions in hepatitis C virus research?

Hugo Ramón Rosen, 
  • Pages: 341-349
  • First Published: 19 September 2016

Reviews

Open Access

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

Juan P. Arab,  Saul J. Karpen,  Paul A. Dawson,  Marco Arrese,  Michael Trauner, 
  • Pages: 350-362
  • First Published: 30 June 2016
Free Access

Liver injury from herbal and dietary supplements

Victor J. Navarro,  Ikhlas Khan,  Einar Björnsson,  Leonard B. Seeff,  Jose Serrano,  Jay H. Hoofnagle, 
  • Pages: 363-373
  • First Published: 27 September 2016

Hepatology Elsewhere

Free Access

New player in tumor-stromal interaction: Granulin as a novel therapeutic target for pancreatic ductal adenocarcinoma liver metastasis

Misako Sato-Matsubara Ph.D.,  Norifumi Kawada M.D., Ph.D., 
  • Pages: 374-376
  • First Published: 19 September 2016
Free Access

Mature peritoneal macrophages take an avascular route into the injured liver and promote tissue repair

Barbara Rehermann M.D., 
  • Pages: 376-379
  • First Published: 24 October 2016

Clinical Observations in Hepatology

Free Access

Biliary adenofibroma: A rare hepatic lesion with malignant features

Paul Kaminsky,  Joshua Preiss,  Eizaburo Sasatomi,  David A. Gerber, 
  • Pages: 380-383
  • First Published: 15 September 2016

Correspondence

Free Access

GNPAT p.D519G variant and iron metabolism during oral iron tolerance test

Raffaela Rametta Ph.D.,  Paola Dongiovanni B.S.,  Silvia Fargion M.D.,  Luca Valenti M.D., 
  • Pages: 384-385
  • First Published: 02 August 2016
Free Access

The use of esophageal stent in controlling acute refractory variceal bleeding

Gin-Ho Lo M.D., 
  • Pages: 385-386
  • First Published: 02 August 2016
Free Access

Reply

Angels Escorsell M.D.,  Jaime Bosch M.D., Ph.D., 
  • Pages: 386-387
  • First Published: 02 August 2016
Free Access

Aquaporin gene therapy for cholestasis

Raúl A. Marinelli Ph.D.,  Julieta Marrone Ph.D., 
  • Pages: 387-388
  • First Published: 26 July 2016
Free Access

Hepatitis E in decompensated alcoholic cirrhosis

Christophe Renou M.D.,  Bruno Lesgourgues M.D.,  Gilles Macaigne M.D.,  Arnaud Pauwels M.D.,  Yann Le Bricquir M.D.,  Jean Henrion M.D.,  Faiza Khemissa M.D.,  Emma Clair M.D.,  Thierry Paupard M.D.,  Agnes Pelaquier M.D.,  Hélène Agostini M.D., Ph.D.,  Anne-Marie Roque-Afonso M.D., Ph.D., 
  • Pages: 388-389
  • First Published: 06 October 2016
Free Access

Reply

Robert J. Fontana M.D.,  Ronald E. Engle M.S.,  Robert H. Purcell M.D.,  William M. Lee M.D.,  On behalf of the ALFSG , 
  • Pages: 389-390
  • First Published: 06 October 2016
Free Access

Drug-induced liver and skin reactions: In need of a consensus definition

Inmaculada Medina-Cáliz Ph.D.,  Mercedes Robles-Díaz M.D., Ph.D.,  M. Isabel Lucena M.D., Ph.D.,  Raul J. Andrade M.D., Ph.D., 
  • Page: 391
  • First Published: 12 September 2016
Free Access

Reply

Harshad Devarbhavi M.D.,  Sujata Raj M.D., 
  • Page: 392
  • First Published: 12 September 2016
Free Access

Are proton pump inhibitors a threat for spontaneous bacterial peritonitis and hepatic encephalopathy in cirrhosis? Not so fast

Muhammad Ali Khan M.D.,  George Cholankeril M.D.,  Colin W. Howden M.D., 
  • Page: 393
  • First Published: 30 September 2016
Free Access

Reply

Gitte Dam Ph.D.,  Hendrik Vilstrup Dm.Sci.,  Hugh Watson Ph.D.,  Peter Jepsen Ph.D., 
  • Pages: 393-394
  • First Published: 29 September 2016
Free Access

No evidence for zoonotic hepatitis E virus infection through dairy milk in Germany

Christine Baechlein Ph.D.,  Paul Becher D.V.M., 
  • Pages: 394-395
  • First Published: 07 October 2016
Free Access

Reply

Fen Huang Ph.D.,  Yunlong Li MS.c.,  Wenhai Yu MS.c.,  Chenchen Yang MS.c., 
  • Pages: 395-396
  • First Published: 07 October 2016

Correction

Free Access

Correction

  • Page: 397
  • First Published: 02 November 2016

Free Access

Correction

  • Page: 397
  • First Published: 02 November 2016

Issue Information

Free Access

Notices

  • First Published: 27 December 2016
Free Access

Instructions to authors and Information for readers

  • First Published: 27 December 2016