• Issue

    European Journal of Immunology: Volume 45, Issue 11

    2961-3204
    November 2015
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Cover Picture

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Cover Picture: Eur. J. Immunol. 11'15

  • First Published: 09 November 2015
Cover Picture: Eur. J. Immunol. 11'15

Our cover features an immunofluorescent staining of a spleen section from a mouse which had been immunized with ovalbumin. The white pulp comprises CD3ɛ-positive T cells (red) and IgM-positive follicular B cells (blue). This is surrounded by a ring of MAdCAM-1-positive sinus-lining cells (green), followed by an outer layer of IgM-positive marginal zone B cells (blue). The image was provided by Preite et al., (pp. 3010–3021) who show that Cd3e-deficient mice, which lack T follicular helper (Tfh) cells, have germinal centre B cells with fewer somatic mutations as compared with wild-type mice, and which exhibit impaired affinity maturation and reduced differentiation into plasma cells. These phenomena could be reversed with reconstitution of Cd3e-deficient mice with wild-type Treg cells, demonstrating that regulated Tfh-cell responses are crucial to develop serological memory.

Editorial Board

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Editorial Board: Eur. J. Immunol. 11'15

  • First Published: 09 November 2015

Contents

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Contents: Eur. J. Immunol. 11'15

  • Pages: 2961-2965
  • First Published: 09 November 2015

Forum

In this issue

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In This Issue

  • Pages: 2966-2967
  • First Published: 09 November 2015

News & EFIS

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World Diabetes Day: Perspectives on immunotherapy of Type 1 Diabetes

Lucienne Chatenoud, 
  • Pages: 2968-2970
  • First Published: 09 November 2015

Highlights

Reviews

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Autoreactivity and the positive selection of B cells

Rudolf Übelhart,  Hassan Jumaa, 
  • Pages: 2971-2977
  • First Published: 19 August 2015
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Perspectives on fetal derived CD5+ B1 B cells

Richard R. Hardy,  Kyoko Hayakawa, 
  • Pages: 2978-2984
  • First Published: 04 September 2015
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Adult thymic epithelial cell (TEC) progenitors and TEC stem cells: Models and mechanisms for TEC development and maintenance

Yoko Hamazaki, 
  • Pages: 2985-2993
  • First Published: 12 September 2015

Commentaries

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γδ T cells come to stay: Innate skin memory in the Aldara model

Immo Prinz,  Inga Sandrock, 
  • Pages: 2994-2997
  • First Published: 21 September 2015
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Enhancing our understanding of enhancers in T-helper cells

Jacob J. Paiano,  John L. Johnson,  Golnaz Vahedi, 
  • Pages: 2998-3001
  • First Published: 07 October 2015
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What would Treg-cell biology look like when viewed from a rationalized perspective?

Melvin Cohn, 
  • Pages: 3002-3009
  • First Published: 08 August 2015

Frontline

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Somatic mutations and affinity maturation are impaired by excessive numbers of T follicular helper cells and restored by Treg cells or memory T cells

Silvia Preite,  Dirk Baumjohann,  Mathilde Foglierini,  Camilla Basso,  Francesca Ronchi,  Blanca M. Fernandez Rodriguez,  Davide Corti,  Antonio Lanzavecchia,  Federica Sallusto, 
  • Pages: 3010-3021
  • First Published: 01 September 2015
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Dermal IL-17-producing γδ T cells establish long-lived memory in the skin

Tom Hartwig,  Stanislav Pantelyushin,  Andrew L. Croxford,  Paulina Kulig,  Burkhard Becher, 
  • Pages: 3022-3033
  • First Published: 02 September 2015

Cellular Immune Response

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Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33

Geethani Bandara,  Michael A. Beaven,  Ana Olivera,  Alasdair M. Gilfillan,  Dean D. Metcalfe, 
  • Pages: 3034-3044
  • First Published: 08 August 2015

Short Communication

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Syndecan-1 identifies and controls the frequency of IL-17-producing naïve natural killer T (NKT17) cells in mice

Hong Dai,  Ayesha Rahman,  Ankit Saxena,  Anil K Jaiswal,  Abdiaziz Mohamood,  Lourdes Ramirez,  Sanjeev Noel,  Hamid Rabb,  Chunfa Jie,  Abdel Rahim A Hamad, 
  • Pages: 3045-3051
  • First Published: 24 August 2015
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IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice

Yuejin Liang,  Zuliang Jie,  Lifei Hou,  Panpan Yi,  Wei Wang,  Zakari Kwota,  Maria Salvato,  Rene de Waal Malefyt,  Lynn Soong,  Jiaren Sun, 
  • Pages: 3052-3063
  • First Published: 07 August 2015

Immunity to infection

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Hematopoietic and nonhematopoietic cells promote Type I interferon- and TLR7-dependent monocytosis during low-dose LCMV infection

Matthew B. Buechler,  Griffin M. Gessay,  Shivani Srivastava,  Daniel J. Campbell,  Jessica A. Hamerman, 
  • Pages: 3064-3072
  • First Published: 19 August 2015
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Lipocalin-2 ensures host defense against Salmonella Typhimurium by controlling macrophage iron homeostasis and immune response

Manfred Nairz,  Andrea Schroll,  David Haschka,  Stefanie Dichtl,  Thomas Sonnweber,  Igor Theurl,  Milan Theurl,  Ewald Lindner,  Egon Demetz,  Malte Aßhoff,  Rosa Bellmann-Weiler,  Raphael Müller,  Romana R. Gerner,  Alexander R. Moschen,  Nadja Baumgartner,  Patrizia L. Moser,  Heribert Talasz,  Herbert Tilg,  Ferric C. Fang,  Günter Weiss, 
  • Pages: 3073-3086
  • First Published: 02 September 2015
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SLy1 regulates T-cell proliferation during Listeria monocytogenes infection in a Foxo1-dependent manner

Daniel Schäll,  Fee Schmitt,  Bernhard Reis,  Simone Brandt,  Sandra Beer-Hammer, 
  • Pages: 3087-3097
  • First Published: 26 August 2015
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LIM-only protein FHL2 regulates experimental pulmonary Schistosoma mansoni egg granuloma formation

Kondababu Kurakula,  Mariska Vos,  Marco van Eijk,  Hermelijn H. Smits,  Carlie J.M. de Vries, 
  • Pages: 3098-3106
  • First Published: 24 August 2015

Short Communication

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Gut commensal microbes do not represent a dominant antigenic source for continuous CD4+ T-cell activation during HIV-1 infection

Kathrin Zimmermann,  Sonia Bastidas,  Leandra Knecht,  Herbert Kuster,  Stephan R. Vavricka,  Huldrych F. Günthard,  Annette Oxenius, 
  • Pages: 3107-3113
  • First Published: 08 September 2015

Immunomodulation

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IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice

Rafael R. Flores,  Eun Kim,  Liqiao Zhou,  Chenjie Yang,  Jing Zhao,  Andrea Gambotto,  Paul D. Robbins, 
  • Pages: 3114-3125
  • First Published: 11 August 2015
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Adoptive transfer of helminth antigen-pulsed dendritic cells protects against the development of experimental colitis in mice

Chelsea E. Matisz,  Gabriella Leung,  Jose Luis Reyes,  Arthur Wang,  Keith A. Sharkey,  Derek M. McKay, 
  • Pages: 3126-3139
  • First Published: 01 September 2015
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T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs

Matthew A. Burchill,  Beth A. Tamburini,  Ross M. Kedl, 
  • Pages: 3140-3149
  • First Published: 15 July 2015

Molecular Immunology

Short Communication

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Transcription factor co-occupied regions in the murine genome constitute T-helper-cell subtype-specific enhancers

Zhuo Fang,  Katharina Hecklau,  Fridolin Gross,  Ivo Bachmann,  Melanie Venzke,  Martin Karl,  Johannes Schuchhardt,  Andreas Radbruch,  Hanspeter Herzel,  Ria Baumgrass, 
  • Pages: 3150-3157
  • First Published: 24 August 2015

Leukocyte signaling

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Extracellular RNA facilitates hypoxia-induced leukocyte adhesion and infiltration in the lung through TLR3-IFN-γ-STAT1 signaling pathway

Indranil Biswas,  Bandana Singh,  Manish Sharma,  Paban K. Agrawala,  Gausal A. Khan, 
  • Pages: 3158-3173
  • First Published: 09 September 2015

Clinical immunology

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Ultraviolet light converts propranolol, a nonselective β-blocker and potential lupus-inducing drug, into a proinflammatory AhR ligand

Karim Dorgham,  Zahir Amoura,  Christophe Parizot,  Laurent Arnaud,  Camille Frances,  Cédric Pionneau,  Hervé Devilliers,  Sandra Pinto,  Rima Zoorob,  Makoto Miyara,  Martin Larsen,  Hans Yssel,  Guy Gorochov,  Alexis Mathian, 
  • Pages: 3174-3187
  • First Published: 10 September 2015
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1,25-Dihydroxy-vitamin D3 regulates NK-cell cytotoxicity, cytokine secretion, and degranulation in women with recurrent pregnancy losses

Kuniaki Ota,  Svetlana Dambaeva,  Michael Woo-Il Kim,  Ae-Ra Han,  Atsushi Fukui,  Alice Gilman-Sachs,  Kenneth Beaman,  Joanne Kwak-Kim, 
  • Pages: 3188-3199
  • First Published: 08 August 2015

Technical comment

Open Access

Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing

Daniel B. Rainbow,  Xin Yang,  Oliver Burren,  Marcin L. Pekalski,  Deborah J. Smyth,  Marcus D. R. Klarqvist,  Christopher J. Penkett,  Kim Brugger,  Howard Martin,  John A. Todd,  Chris Wallace,  Linda S. Wicker, 
  • Pages: 3200-3203
  • First Published: 07 September 2015

Impressum

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Impressum

  • Page: 3204
  • First Published: 09 November 2015