• Issue

    Journal of the European Academy of Dermatology and Venereology: Volume 39, Issue 5

    875-1057, e385-e463
    May 2025
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ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 875-880
  • First Published: 25 April 2025

EDITOR’S PICKS

Free Access

Editor’s Picks May 2025

  • Pages: 881-882
  • First Published: 25 April 2025

COMMENTARY

Open Access

Darier disease: Golden era of discovery and global collaborations

Sofia Labbouz,  Roni P. Dodiuk-Gad, 
  • Pages: 883-884
  • First Published: 25 April 2025

Open Access

Topical minocycline foam: A new option for acne treatment?

Evgenia Makrantonaki, 
  • Pages: 885-886
  • First Published: 25 April 2025

Open Access

Interdisciplinary care in immune-mediated inflammatory diseases with skin manifestations within the WHO's people-centred healthcare framework

Rachel Sommer,  Matthias Augustin, 
  • Pages: 887-888
  • First Published: 25 April 2025

Open Access

Emergency for dermatologic wards?

Falk Ochsendorf, 
  • Pages: 889-890
  • First Published: 25 April 2025

Open Access

Clonal disorders of clinical significance. A concept with important therapeutic implications

Dan Lipsker, 
  • Pages: 891-892
  • First Published: 25 April 2025

Open Access

Epidermolytic ichthyosis: New insights and ongoing challenges

J. Mazereeuw-Hautier, 
  • Pages: 893-894
  • First Published: 25 April 2025

Open Access

Er:YAG laser ablation: Possibly a valuable tool in the management of refractory Hailey–Hailey disease

Danielle Rogner, 
  • Pages: 895-896
  • First Published: 25 April 2025

Open Access

Who treats matters: Elevating LGBTQI dermatology

Tiago R. Matos,  Myrto Trakatelli, 
  • Pages: 897-898
  • First Published: 25 April 2025

GUIDELINES

Open Access

European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment

C. C. Zouboulis,  F. G. Bechara,  F. Benhadou,  V. Bettoli,  Z. Bukvić Mokos,  V. Del Marmol,  M. Dolenc-Voljč,  E. J. Giamarellos-Bourboulis,  Ø. Grimstad,  P. Guillem,  B. Horváth,  R. E. Hunger,  J. R. Ingram,  D. Ioannidis,  E. Just,  L. Kemény,  B. Kirby,  A. I. Liakou,  B. M. McGrath,  A. V. Marzano,  Ł. Matusiak,  A. Molina-Leyva,  A. Nassif,  M. Podda,  E. P. Prens,  F. Prignano,  H. Raynal,  M. Romanelli,  D. M. L. Saunte,  A. Szegedi,  J. C. Szepietowski,  T. Tzellos,  S. Valiukevičienė,  H. H. van der Zee,  K. R. van Straalen,  B. Villumsen,  G. B. E. Jemec, 
  • Pages: 899-941
  • First Published: 19 December 2024
European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment

HS treatment algorithm.

REVIEW ARTICLE

Open Access

Darier disease: Current insights and challenges in pathogenesis and management

Monika Ettinger,  Susanne Kimeswenger,  Isabella Deli,  Judith Traxler,  Sabine Altrichter,  Petar Noack,  Jakob D. Wikstrom,  Emmanuella Guenova,  Wolfram Hoetzenecker, 
  • Pages: 942-951
  • First Published: 28 November 2024

Darier disease: Current insights and challenges in pathogenesis and management

Darier disease (DD) is characterized by the following: Disrupted Ca2+ gradients, impaired desmosomes, impaired keratinocyte differentiation, type 17 inflammation, DC and LC ↓, Th17 cells ↑. DD treatment: First line: keratinocyte focused and/or anti-inflammatory. Second line: experimental approaches like specific targeting of the inflammatory infiltrate.

ORIGINAL ARTICLE AND SYSTEMATIC REVIEW

ACNE

Open Access

International expert consensus recommendations for the use of dermocosmetics in acne

Diane Thiboutot,  Alison M. Layton,  Ibrahima Traore,  Gabriel Gontijo,  Patricia Troielli,  Qiang Ju,  Ichiro Kurokawa,  Brigitte Dreno, 
  • Pages: 952-966
  • First Published: 15 June 2024

Efficacy and safety of topical minocycline foam (FMX101 4%) in treatment of Chinese subjects with moderate-to-severe facial acne vulgaris: A phase 3, multi-centre, randomized, double-blind, vehicle-controlled study

Yan Le,  Wenlin Yang,  Jianyun Lu,  Xian Jiang,  Qing Guo,  Chunyun Huang,  Qing Sun,  Huiping Wang,  Mingye Bi,  Haiying Wang,  Songmei Geng,  Bin Yang,  Ai-E Xu,  Yong Cui,  Xiaoyong Man,  Yi Zhao,  Litao Zhang,  Linfeng Li,  Zhiqiang Song,  Jin Chen,  Hao Cheng,  Wei Zhu,  Xiuping Han,  Shanshan Li,  Tong Lin,  Chunlei Zhang,  Jiuhong Li,  Yanling Li,  Yangfeng Ding,  Linda Wang,  Yuefang Zhu,  Leihong Xiang, 
  • Pages: 967-975
  • First Published: 01 July 2024

INTERNAL MEDICINE AND SKIN

Open Access

Dermatologic manifestations of hereditary hemochromatosis: A systematic review

Hossein Akbarialiabad,  Parnian Jamshidi,  Jeffrey P. Callen,  Dédée F. Murrell, 
  • Pages: 976-986
  • First Published: 16 May 2024

Experience of patients and healthcare practitioners with interdisciplinary care in immune-mediated inflammatory diseases with skin manifestations: A systematic scoping review

Ellen Van den Steen,  Diederik De Cock,  Jo Lydie Wilfried Lambert,  Valerie Reynaert,  Kilian Eyerich,  Branka Marinović,  Jan Gutermuth, 
  • Pages: 987-1000
  • First Published: 07 December 2024

Experience of patients and healthcare practitioners with interdisciplinary care in immune-mediated inflammatory diseases with skin manifestations: A systematic scoping review

This scoping review gathers evidence on patient- and HCP perceptions on interdisciplinary care (IC) for Immune-mediated inflammatory Diseases with Skin manifestations (skIMID) and state-of-the-art of measurement. IC experience is captured very heterogeneously and strongly depends on the context of the care provider. Experience seems to be better in local programmes than systems rolled out in larger geographical regions. Future need is to develop a standardized core IC outcome set, including medical-, process- and financial indicators, patient and HCP care experience measures. Such data will support benchmarking and identification of improvement areas in quality of care.

Open Access

Dermatological emergencies and determinants of hospitalization in Switzerland: A retrospective study

S. Cazzaniga,  K. Heidemeyer,  C. A. Zahn,  S. M. Seyed Jafari,  T. C. Sauter,  L. Naldi,  L. Borradori, 
  • Pages: 1001-1010
  • First Published: 22 June 2024

Open Access

Plasma cell-directed therapies induce profound clinical and durable responses in patients with severe or relapsed/refractory scleromyxedema

F. Theves,  C. Lahuna,  T. Mahévas,  S. Harel,  B. Royer,  V. Lemiale,  A. Brignier,  N. Parquet,  M. Jachiet,  J.-D. Bouaziz,  D. Elessa,  B. Arnulf,  A. Talbot, 
  • Pages: 1011-1016
  • First Published: 31 July 2024

Plasma cell-directed therapies induce profound clinical and durable responses in patients with severe or relapsed/refractory scleromyxedema

In severe forms of monoclonal gammapathy associated with scleromyxoedema with dermatoneuro syndrome and/or cardiac involvement, deep and durable responses allowing IVIG withdrawal could be achieved using anti-plasma cell therapy, including Imids, anti-CD38 or proteasome inhibitors.

Open Access

Epidemiology and treatment of Adamantiades–Behçet's disease in Germany: A healthcare claims database study

C. C. Zouboulis,  J. Borchert,  J. Diesing,  R. Heinrich,  W. Galetzka,  J.-P. Medelnik,  A. Altenburg,  A. Feldhus,  T. Schönfelder, 
  • Pages: 1017-1027
  • First Published: 12 December 2024
Epidemiology and treatment of Adamantiades–Behçet's disease in Germany: A healthcare claims database study

Epidemiology, associated comorbidities and current treatment patterns of Adamantiades–Behçet's disease in Germany.

RARE SKIN DISEASES

Open Access

Epidermolytic ichthyosis: Clinical spectrum and burden of disease in a large German cohort

Leonie Frommherz,  Kathrin Giehl,  Josephine Hofmann,  Stefanie Huebner,  Kirstin Kiekbusch,  Teodora Sabkova,  Kira Süßmuth,  Svenja Alter,  Iliana Tantcheva-Poór,  Hagen Ott,  Judith Fischer,  Cristina Has, 
  • Pages: 1028-1037
  • First Published: 13 May 2024

Open Access

Long-term remission of Hailey–Hailey disease by Er:YAG ablative laser therapy

Marie-Eline P. H. Debeuf,  Kèvin Knoops,  Carmen López-Iglesias,  Eline Lookermans,  Patty J. Nelemans,  Myrurgia Abdul Hamid,  Michel van Geel,  Antoni H. Gostynski,  Peter M. Steijlen,  Marieke C. Bolling,  Valerie L. R. M. Verstraeten, 
  • Pages: 1038-1045
  • First Published: 01 October 2024

Long-term remission of Hailey–Hailey disease by Er:YAG ablative laser therapy

Upper left panel: Hailey–Hailey lesion at baseline, directly after, 6 weeks and 3 years after a single Er:YAG laser ablation. Long-term remission was noted in 75/77 Hailey–Hailey plaques after a median follow-up of 38 months. Upper right panel: Median quality of life scores at baseline, 6 weeks and 3 years after laser ablation with a significant improvement at 6 weeks and 3 years after laser ablation. Bottom left panel: Electron microscopy of keratinocytes in the stratum spinosum at baseline and 6 weeks after laser ablation. Laser-treated skin showed an increased number of desmosomes, decreased intercellular distance and decreased perinuclear retraction of keratin filaments. Bottom right panel: Cross-section of the skin on the right side showing the depth of laser ablation. Laser ablation up to mid-dermis induced long-term remission of Hailey–Hailey disease.

Long-term effects of sirolimus treatment for slow-flow vascular malformations: Real-world evidence from the French observational multicentre SIROLO study

Cécilia Maillet,  Olivia Boccara,  Stéphanie Mallet,  Didier Bessis,  Christine Labrèze,  Sorilla Mary-Prey,  Laurent Guibaud,  Annouk Bisdorff,  Anne Dompmartin,  Juliette Mazereeuw-Hautier,  Christine Chiaverini,  Thomas Hubiche,  Bertille Bonniaud,  Caroline Degrugillier-Chopinet,  Anne-Claire Bursztejn,  Hélène Aubert,  Maella Severino,  Sophie Leducq,  Mathilde Tardieu,  Aline Joly,  Grégoire Boulouis,  Anne Le Touze,  Arnaud Paré,  Elsa Tavernier,  Annabel Maruani, 
  • Pages: 1046-1054
  • First Published: 25 November 2024

Long-term effects of sirolimus treatment for slow-flow vascular malformations: Real-world evidence from the French observational multicentre SIROLO study

Overall, 67 patients were included from 15 French centres (35 children and 32 adults). After the first sirolimus temporary withdrawal, mean time to recurrence of symptoms was 6.4 ± 9.6 months (survival curve). Sirolimus was overall well-tolerated (radar chart). Serious adverse events occurred in six patients (9.0%), especially respiratory infections. There were two cases of ovarian cysts. Conclusion. The real-life study SIROLO provides answers on persistence of efficacy over time, long-term side effects and time to recurrence in case of sirolimus withdrawal.

ANNOUNCEMENT

Announcement

  • Page: 1055
  • First Published: 25 April 2025

Announcement

  • Page: 1056
  • First Published: 25 April 2025

Announcement

  • Page: 1057
  • First Published: 25 April 2025

LETTER TO THE EDITOR

Excellent response to cemiplimab and radiotherapy in advanced metastatic porocarcinoma

Nessr Abu Rached,  Vasileios Dervenis,  Christina Scheel,  Markus Stücker,  Christian Baues,  Cornelia Mauch,  Martin Doerler, 
  • Pages: e385-e387
  • First Published: 22 August 2024

Erectile dysfunction in patients with seborrhoeic dermatitis

Corinne Rabbin-Birnbaum,  Keana Khodadad,  Jill T. Shah,  John G. Zampella, 
  • Pages: e388-e390
  • First Published: 22 August 2024

A cluster of early syphilis cases with ocular manifestations on the island of Crete

Dimitra Koumaki,  Georgios Evangelou,  Faidra Marazaki,  Danae Petrou,  Maria Gorgomiti,  Stamatios Gregoriou,  Petros Ioannou,  Vasiliki Koumaki,  Efstathios T. Detorakis,  Aikaterini Chalkia,  Maria Vavouranaki,  Konstantinos Krasagakis, 
  • Pages: e391-e393
  • First Published: 18 September 2024

Improvements in patient-reported outcomes with oral roflumilast for psoriasis: Results from a randomized controlled trial (PSORRO)

Mette Gyldenløve,  Jennifer Astrup Sørensen,  Simon Francis Thomsen,  Simon Fage,  Lars Iversen,  Lone Skov,  Claus Zachariae,  Alexander Egeberg,  Mia-Louise Nielsen, 
  • Pages: e394-e397
  • First Published: 19 September 2024

Tangential biopsy of the nail bed and matrix, with plate evaluation, for diagnosis of lichen planus

L. Bertanha,  A. O. Michalany,  I. I. Damas,  N. Di Chiacchio,  M. L. Cintra, 
  • Pages: e398-e400
  • First Published: 20 September 2024

Oesophageal lichen planus: Clinical, endoscopic and fibroscopic characteristics

A. Kayal,  M. H. Tessier,  J.-C. Fricain,  E. Vigarios,  V. Seta,  C. Isnard,  C. Husson,  C. Le Roux-Villet,  A. Du-Thanh,  C. Girard,  G. Velut,  M. Samimi,  M. Kayal,  M. Le Moigne,  the GEMUB Group and the French Society of Dermatology , 
  • Pages: e401-e403
  • First Published: 26 September 2024

Mycophenolate mofetil as a steroid-sparing agent in oral mucous membrane pemphigoid: A retrospective review

Katie K. Lovell,  Matthew L. Hrin,  Joseph L. Jorizzo,  Lindsay C. Strowd, 
  • Pages: e404-e406
  • First Published: 26 September 2024

Epidemiological analysis of mycosis fungoides (MF) in children and young adult patient populations: A population-based analysis of the nationwide surveillance, epidemiology and end results (SEER) database

Kripa R. Ahuja,  Walter J. Liszewski,  Joan Guitart,  Abel Kho,  Dennis P. West,  Beatrice Nardone, 
  • Pages: e407-e409
  • First Published: 12 October 2024

Effectiveness and safety of risankizumab dose optimization in adult patients with plaque psoriasis: An international multicentre retrospective cohort study

A. Bagit,  K. Maliyar,  M. Mansour,  J. R. Georgakopoulos,  B. Rankin,  Y. Lytvyn,  H. Zaaroura,  Y. J. Park,  E. Wang,  A. Mufti,  T. Torres,  A. M. Le,  R. Vender,  V. H. Prajapati,  J. Yeung, 
  • Pages: e410-e412
  • First Published: 15 October 2024

The effect of cigarette smoking on Behcet's disease outcomes: A multicentre study

Majid Alikhani,  Roya Zaj,  Tahereh Faezi,  Kamal Esalatmanesh,  Rojin Farzaneh,  Sousan Kolahi,  Maryam Saberivand,  Alireza Khabbazi, 
  • Pages: e413-e416
  • First Published: 21 October 2024

Clearance of Darier disease lesions in a patient with concomitant atopic dermatitis treated with abrocitinib

M. Bianco,  S. Di Giulio,  L. Ibba,  A. Narcisi,  A. Costanzo,  L. Gargiulo, 
  • Pages: e417-e419
  • First Published: 22 October 2024

Assessing dermatologists-venereologists' awareness, vigilance and attitude towards LGBT individuals: A cross-sectional study in Greece

Aikaterini Tsentemeidou,  Nikolaos Chaitidis,  Ilias Papadimitriou,  Vasileios Paraschou,  Themis Chatzi-Sotiriou,  Olga Pikou,  Dimitra Kiritsi,  Efstratios Vakirlis,  Elena Sotiriou, 
  • Pages: e420-e423
  • First Published: 23 October 2024

ApreScalp: A Phase 4 multicentre, randomized, placebo-controlled study evaluating the effect of apremilast on pruritus and quality of life of patients with moderate-to-severe scalp psoriasis

Sara E. Cerminara,  Ivana Cvijetic,  Stephanie Huber,  Simon Müller,  Lisa Kostner,  Elisabeth V. Goessinger,  Jasmin Narainsing,  Gilles Dutilh,  Kristine Heidemeyer,  Nikhil Yawalkar,  Curdin Conrad,  Tobias Plaza,  Julia-Tatjana Maul,  Antonio Cozzio,  Alexander A. Navarini, 
  • Pages: e424-e426
  • First Published: 24 October 2024

Nail clipping may not be sufficient to corroborate the diagnosis of psoriasis

L. Bertanha,  N. G. Di Chiacchio,  N. Di Chiacchio,  M. L. Cintra, 
  • Pages: e427-e429
  • First Published: 05 November 2024

Cardiovascular events in patients with psoriasis and psoriatic arthritis treated with JAK/TYK inhibitors: A systematic review and meta-analysis

Marina Mordehachvili Burlá,  Izabela Pera Calvi,  Regina Chahine Chater,  Rafaela de Moraes-Souza,  Vladimir V. Rafalskiy,  Pedro Herranz-Pinto,  George Doumat,  Maria Tsoukas,  Roger Haber, 
  • Pages: e430-e435
  • First Published: 07 November 2024

Effects of comorbidities on delayed wound healing in patients with pyoderma gangrenosum

Hannah Zhao,  Sidharth K. Sengupta,  Olivia Haddadin,  Jonathan M. Sisley,  Katelyn Downey,  Alex G. Ortega-Loayza, 
  • Pages: e436-e438
  • First Published: 26 November 2024

Robustness of automated acne lesion detection across various imaging conditions: A comparative analysis with dermatologists

Ji Su Lee,  Byeol Han,  Hoonjae Lee,  Daejeong Moon,  Daeseon Kim,  Terry TaeWoong Um,  Soo Ick Cho,  Jung-Im Na, 
  • Pages: e439-e441
  • First Published: 04 December 2024

Upadacitinib for orofacial granulomatosis associated with Crohn's disease

Gaëlle Colin,  Manon Girod,  Emilie Malezieux,  Romain Altwegg,  Céline Girard, 
  • Pages: e442-e443
  • First Published: 07 December 2024

Systemic anti-inflammatory therapy in congenital ichthyosis: Real-world experience in a series of 22 cases

Laura Katharina Trefzer,  Miodrag Davidovic,  Donglin Li,  Meropi Karakioulaki,  Federica Casetti,  Christoph M. Schempp,  Kilian Eyerich,  Cristina Has, 
  • Pages: e444-e447
  • First Published: 11 December 2024

Dapagliflozin-associated chronic balanitis due to Streptococcus agalactiae

Caroline Donzel,  Romain Salle,  Jean-David Bouaziz,  Sébastien Fouéré,  Tu-Anh Duong,  Jean-Noël Dauendorffer, 
  • Pages: e448-e450
  • First Published: 13 December 2024

Enhancing multimodal deep learning for improved precision and efficiency in medical diagnostics

Keyan Jin, 
  • Pages: e451-e452
  • First Published: 29 May 2024

Response to ‘Enhancing multimodal deep learning for improved precision and efficiency in medical diagnostics’

Kaili Chen,  Zhi Yang,  Qianwen Li,  Hai Long,  Rong Xiao,  Kai Hu,  Haijing Wu,  Qianjin Lu, 
  • Pages: e453-e455
  • First Published: 20 September 2024

Effective and safe use of benzyl benzoate in young children at the same concentrations as adults: A matter of vehicle?

Andrea Bassi,  Vincenzo Piccolo,  Giuseppe Argenziano,  Mario Cutrone,  Carlo Mazzatenta, 
  • Pages: e456-e457
  • First Published: 29 July 2024

Reply to ‘Burnout and professional quality of life in dermatologists’

V. Picone,  M. Napolitano,  C. Marasca,  M. Cantelli,  V. Greco,  L. Coronella,  C. Patruno, 
  • Pages: e458-e459
  • First Published: 04 October 2024

Enhancing HFUS accuracy in melanoma assessment: The role of artificial intelligence and statistical precision

I. Chen,  S. Yu, 
  • Pages: e460-e461
  • First Published: 05 November 2024

Response—Letter to the Editor: High-frequency ultrasound accuracy in preoperative cutaneous melanoma assessment

Georgina E. Sellyn,  Andrea A. Lopez,  Shramana Ghosh,  Michael C. Topf,  Heidi Chen,  Eric Tkaczyk,  Jennifer G. Powers, 
  • Pages: e462-e463
  • First Published: 07 January 2025