The study aimed to assess happiness among psoriasis and atopic dermatitis patients from 8 European countries. Patients ≥18 years of age were asked to complete a questionnaire on happiness and quality of life. Differences between psoriasis and atopic dermatitis patients and between the European countries were analysed. Psoriasis and atopic dermatitis patients showed similar levels of happiness, while patients with psoriasis showed higher quality of life. Both happiness and quality of life varied between European countries, with Austrian patients displaying the highest happiness levels. Equality in treatment access is imperative, alongside the development of targeted positive psychological interventions to enhance happiness.

Graphical abstract of the study on cutaneous squamous cell carcinoma in situ, commonly known as Bowen's disease, with the primary objective of comparing the efficacies of different treatment interventions. The top right corner section depicts the methods used herein: the study begins with a systematic literature search to identify relevant studies. Subsequently, a quality assessment of the studies is conducted. Data extraction focuses on several key metrics: lesion clearance ates (LCR), participant clearance rates (PCR), lesion recurrence rates (LRR), participant recurrence rates (PRR) and baseline characteristics. The extracted data are then used to group the various interventions, including PDT, 5% 5-FU, cryotherapy and surgery, among others. Two meta-analyses of proportions are conducted for each outcome using a generalized linear mixed model: one focusing exclusively on high-quality studies, and another encompassing all study arms to ensure comprehensive results. At the bottom left, the meta-analysis process using forest plots is illustrated. The treatment efficacies are presented in descending order in treatment rankings, exemplified with a ranking of LCR. At the bottom right, the conclusions are stated: the efficacy comparison provides a thorough overview of the efficacy outcomes for practice-relevant interventions in treating Bowen's disease. Additionally, the study addresses the challenges in comparability, highlighting the variability in treatment rankings across LCR, PCR, LRR and PRR. It also discusses the limitations in comparability due to the different numbers of studies between treatment groups and outcome measures, as well as methodical and clinical heterogeneity.

Key confocal features in LM/LMM progression: Architecture: AIMP: Preserved; LM: Non-edged papillae; LMM: Epidermal/junctional disarray, collagen fibre destruction. Cellular distribution: AIMP: Junctional scattered atypical cells; LM: Widespread pagetoid and junctional atypical cells with junctional nests; LMM: Widespread pagetoid and junctional atypical cells with junctional and dermal nests. Cell Types: AIMP: Dendritic cells with mild atypia; LM/LMM: Dendritic cells with mild atypia, round nucleated cells with marked atypia.

When compared with the gold standard histopathologic examination, the non-invasive RCM imaging technique has a negative predictive value (true negative margins confirmed by histopathology among all negative margins analysed by RCM) of 89.15%, highlighting its efficacy for margin mapping of melanoma of the lentigo maligna type.

Along with experiencing stigmatization in social contexts, individuals with visible chronic skin disease often deal with self-stigma. The graphical abstract depicts an adapted model from Germain and colleagues (2021) and highlights correlates, predictors and outcomes associated with self-stigma for people with atopic dermatitis, psoriasis, vitiligo, alopecia areata or hidradenitis suppurativa according to the present systematic literature review of 27 included studies. Study quality ratings were good although majority of the reviewed studies were cross-sectional and causal inferences could not be made. Psychosocial correlates to self-stigmatization with supporting evidence in both Germain and colleagues' (2021) model and the current review were noted with an asterisk (*), whereas additional correlates found in our review were emphasized in red text. Several psychosocial correlates were considered modifiable, such as social stigma, coping strategies and social support, and therefore potential targets for psychosocial interventions (highlighted in green and pathways depicted with solid green lines), while others were not (depicted with dashed grey lines). The figure also identifies measurable outcomes (highlighted in blue) for future interventions.

This study systematically analysed peer-reviewed publications describing use of the DLQI in validation of other PRO and QoL measures and identified widespread use of the DLQI as a benchmark in validation of other dermatology PRO/QoL measures. It confirms the central role DLQI plays in the development of novel instruments and validation across dermatology and beyond.