Conventional PDT versus one PDT session plus 3% diclofenac gel for severe skin field cancerization of the face and scalp: Randomized controlled trial assessing clinical and histological response
Corresponding Author
Gerald Selda-Enriquez
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Correspondence
Gerald Selda-Enriquez and María Asunción Ballester-Martínez, Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Carretera Colmenar Viejo km 9.100, Madrid 28034, Spain.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
María Asunción Ballester-Martínez
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Correspondence
Gerald Selda-Enriquez and María Asunción Ballester-Martínez, Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Carretera Colmenar Viejo km 9.100, Madrid 28034, Spain.
Email: [email protected] and [email protected]
Search for more papers by this authorBibiana Pérez-García
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorLorea Bagazgoitia
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorGonzalo Segurado-Miravalles
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorÁngela Hermosa-Gelbard
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorEva Hermosa-Zarza
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorCarmen Moreno-García Del Real
Pathology Department, Ramón y Cajal University Hospital, Madrid, Spain
Search for more papers by this authorLucía Turrión-Merino
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorSalvador González
Department of Medicine and Medical Specialties, University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorÁngeles Juarranz
Department of Biology, Faculty of Sciences, Universidad Autónoma de Madrid, Madrid, Spain
Search for more papers by this authorPedro Jaén
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorMontserrat Fernández-Guarino
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorCorresponding Author
Gerald Selda-Enriquez
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Correspondence
Gerald Selda-Enriquez and María Asunción Ballester-Martínez, Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Carretera Colmenar Viejo km 9.100, Madrid 28034, Spain.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
María Asunción Ballester-Martínez
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Correspondence
Gerald Selda-Enriquez and María Asunción Ballester-Martínez, Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Carretera Colmenar Viejo km 9.100, Madrid 28034, Spain.
Email: [email protected] and [email protected]
Search for more papers by this authorBibiana Pérez-García
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorLorea Bagazgoitia
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorGonzalo Segurado-Miravalles
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorÁngela Hermosa-Gelbard
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorEva Hermosa-Zarza
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorCarmen Moreno-García Del Real
Pathology Department, Ramón y Cajal University Hospital, Madrid, Spain
Search for more papers by this authorLucía Turrión-Merino
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorSalvador González
Department of Medicine and Medical Specialties, University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorÁngeles Juarranz
Department of Biology, Faculty of Sciences, Universidad Autónoma de Madrid, Madrid, Spain
Search for more papers by this authorPedro Jaén
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorMontserrat Fernández-Guarino
Department of Dermatology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), University of Alcalá de Henares, Madrid, Spain
Search for more papers by this authorOpen Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
REFERENCES
- 1Ziegler A, Jonason AS, Leffellt DJ, Simon JA, Sharma HW, Kimmelman J, et al. Sunburn and p53 in the onset of skin cancer. Nature. 1994; 372(6508): 773–776.
- 2Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A. Field cancerization: definition, epidemiology, risk factors, and outcomes. J Am Acad Dermatol. 2020; 83(3): 709–717.
- 3Morton C a, Szeimies RM, Basset-Séguin N, Calzavara-Pinton P g, Gilaberte Y, Hædersdal M, et al. European dermatology forum guidelines on topical photodynamic therapy 2019 part 2: emerging indications – field cancerization, photorejuvenation and inflammatory/infective dermatoses. J Eur Acad Dermatol Venereol. 2020; 34(1): 17–29.
- 4Wolf JE Jr, Taylor JR, Tschen E, Kang S. Topical 3.0% diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses. Int J Dermatol. 2001; 40(11): 709–713.
- 5Jansen MHE, Kessels JPHM, Nelemans PJ, Kouloubis N, Arits AHMM, van Pelt HPA, et al. Randomized trial of four treatment approaches for actinic keratosis. N Engl J Med. 2019; 380(10): 935–946.
- 6Jordan M, Ghoreschi K, Eberle FC. Daylight photodynamic therapy for severe facial and scalp actinic keratosis: a prospective non-sponsored single-centre study employing the actinic keratosis area and severity index (AKASI). Eur J Dermatol. 2019; 29(1): 67–74.
- 7Piaserico S, Mazzetto R, Sartor E, Bortoletti C. Combination-based strategies for the treatment of actinic Keratoses with photodynamic therapy: an evidence-based review. Pharmaceutics. 2022; 14(8): 1726.
- 8Lucena SR, Salazar N, Gracia-Cazaña T, Zamarrón A, González S, Juarranz Á, et al. Combined treatments with photodynamic therapy for non-melanoma skin cancer. Int J Mol Sci. 2015; 16(10): 25912–25933.
- 9Van der Geer S, Krekels GAM. Treatment of actinic keratoses on the dorsum of the hands: ALA-PDT versus diclofenac 3% gel followed by ALA-PDT. A placebo-controlled, double-blind, pilot study. J Dermatol Treat. 2009; 20(5): 259–265.