This systematic review compares LNM+, LNM + TD+ and LNM + ENE+ cases using network meta-analyses. As LNM+TD+ has a worse outcome than LNM +E NE+ and both groups perform worse than cases with LNM only, more emphasis on both ENE and TD in the TNM classification is needed, with the most prominent role for TD.

This review summarizes the common diagnostic pitfalls in malignant papillary tumours of the breast, with particular focus on encapsulated papillary carcinoma, and provide an approach to the diagnostic evaluation and categorisation of these enigmatic entities.

The histological changes in liver biopsies taken during the normothermic machine perfusion (NMP) pathway predominantly comprise donor-derived macrovesicular steatosis, stress-associated small droplet steatosis, retrieval/procedure-associated sinusoidal dilation and ischaemic injury. Regional variations in necrosis extent are likely to limit the utility of biopsies taken during NMP to assess organ quality.

In this retrospective study of 80 patients with biopsy-proven hepatic inflammatory pseudotumour (IPT), patients commonly have a history of biliary disease (15%) or prior intraabdominal surgery (24%). Most patients with available clinical follow-up demonstrated radiologic resolution and/or had repeat negative biopsy; a minority of patients (8%) were subsequently diagnosed with neoplastic hepatic lesions.

GATA3 retains high sensitivity in HR+ cancers, even after HR loss during metastasis. TRPS1 and SOX10 were expressed in more than 50% of concordant TNBC cases, indicating their utility in identifying TNBC metastasis.

CTNNB1 mutations were found in 13% of cases, exclusively in exon 3, with mutations at D32-S37, T41 and S45. CTNNB1 mutations correlated strongly with diffuse strong glutamine synthetase (GS) expression, nuclear β-catenin expression and classic CTNNB1 morphology.

Expression of neuroendocrine markers in oesophageal adenocarcinoma after neoadjuvant chemoradiation is independently associated with reduced overall survival. Assessment of neuroendocrine differentiation is a useful tool for predicting patient outcome.

Morphological features of RCOR1::GRHL2 adnexal tumour (case 4).

The tumour was covered by respiratory mucosa without metaplastic or dysplastic changes with branched glands of REAH descending from the surface respiratory epithelium into the stroma with budding structures of SH and ASGSH glands (A). Detailed SH transforming into ASGSH (B). AMP staining showing ASGSH with reduced brush border and mucin production (C). REAH glands were branched and consisted of multiple layers of secretory and myoepithelial cells with irregular and disorganized stratification and chaotic arrangement of nuclei (D).

Distinctive histopathological features of paediatric MDS with UBTF-TD include hyperplastic myelopoiesis with severe atypia, frequent micromegakaryocytes, and immature erythropoiesis with circulating normoblasts. These findings may aid in the early diagnosis and guide targeted molecular testing and treatment strategies, which are critical to improving patient outcomes.

This represents the first population-based study investigating the prevalence of the different TCGA molecular groups of endometrial carcinomas in an unselected population. Performing molecular testing on biopsies enables management to be tailored to the molecular group and allows integration of the TCGA group into the report of the final resection specimen.

Cancer infiltrates in prostate biopsies are reported in various ways, commonly in percentages or mm, which was confirmed in a survey of genitourinary pathologists. Further, 10 typical cases mirrored this variability in practice. A greater variability was seen for percentages in reporting prostate cancer extent. Therefore, absolute measures (mm) are preferable.