The cover image is based on the Short Report A nodal EBV-positive T cell lymphoma with a T follicular helper cell phenotype by Zhaoxuan Zhang et al., https://doi.org/10.1111/his.14919.

PRAME immunohistochemistry may serve as an ancillary marker to support the diagnosis of melanoma, but its performance is low in spitzoid lesions. The meta-analysis suggests that the 3+/50% threshold might be more useful in practice than the widely recommended 4+/75%, as it shows higher sensitivity with retained satisfactory specificity.

Currently, all VSCC are treated similarly, irrespective of HPV and p53 status. Our findings suggest that in the future, the treatment of VSCC might be tailored in accordance with these molecular subgroups (HPV-associated VSCC, HPV-independent VSCC with wildtype p53, HPV-independent VSCC with mutated p53), given their different prognosis and behaviour.

We describe the largest and most comprehensive series of metastatic solid tumours to the penis with 109 cases. Penile metastases often occurred in the setting of advanced metastatic disease and were associated with poor prognosis. The most frequent primary site was the genitourinary tract, specifically the prostate.

Intraosseous hibernomas are rare benign tumours most frequently detected as small sclerotic lesions in the spine and pelvis of older adults. Clinically and on imaging studies, these tumours frequently raised concern for a metastasis. Accurate classification is needed to prevent unnecessary procedures and assuage fears of an aggressive process.

Alveolar rhabdomyosarcoma is characterised by an oncogenic translocation involving PAX3 or PAX7 and FOXO1; identification of this translocation is important for diagnostic classification. This study suggests that among rhabdomyosarcomas, FOXO1 immunohistochemistry is a highly sensitive and relatively specific surrogate marker of the PAX3/7::FOXO1 fusion oncoprotein.

Two cases with AHRR::NCOA3 fusion were included in 12 cases of angiofibroma of soft tissue (AFST). Diffusely distributed CD163-positive cells were different from true neoplastic cells that were positive for desmin to varying degrees.

This Delphi study provides an overview of current clinical practice regarding STIC diagnosis amongst an international panel of expert gynecopathologists. The experts' consensus statements form the basis for a set of recommendations, which may help towards more consistent STIC diagnosis.

Using three different definitions of margin involvement in malignant polyps, between 26.6 and 50% of polyps were placed in a ‘low risk’ category with adverse outcomes in 1.6–6.3% of cases. Using a new definition may prevent many patients needing to undergo radical surgery.

This study catalogued and compared the pattern of metastatic disease in germline BRCA1/2 pathogenic mutation carriers and non-carriers with breast, ovarian and prostate cancer from a rapid autopsy programme. Our findings suggest that metastatic patterns of breast and ovarian cancers maybe impacted by BRCA1/2 carrier status, suggesting that tumours derived from patients with these mutations use different mechanisms of dissemination.

TRPS1 expression is sensitive and specific for extramammary Paget disease of the vulva and scrotum. Melanoma in situ and secondary tumours with pagetoid spread, including urothelial carcinoma, are negative for TRPS1.

This study presents the largest series of inflammatory myofibroblastic tumours (IMTs), which were subjected to comprehensive analysis of kinase gene rearrangements. A combination of non-expensive PCR test for 5′/3′-end unbalanced gene expression, variant-specific PCR and NGS revealed gene fusions in 71 of 82 (87%) IMTs. Some rearrangements demonstrated age- and organ-dependent distribution.

DNA content abnormality is frequently detected in the right/proximal colon in patients with primary sclerosing cholangitis and inflammatory bowel disease even before dysplasia is diagnosed, and is highly predictive of subsequent detection of dysplasia, in particular, nonconventional and/or invisible dysplasias.

Low PD-L1 expression by immune cells predicts lymph node metastasis in pT1 colorectal carcinoma. PD-L1 CPS < 1.2 and PD-L1 ICS < 1.3% were determined to be the optimal cut-off values, allowing the identification of metastatic patients and thus to potentially avoid a significant rate of unnecessary surgeries.