Genetic Analysis of Complex trait: Insulin‐Department Diabetes Mellitus and Affective Disorders: Genetic Epidemiology: Vol 6, No 1

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Genetic Epidemiology

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Genetic Epidemiology: Volume 6, Issue 1

Special Issue:Genetic Analysis of Complex trait: Insulin‐Department Diabetes Mellitus and Affective Disorders

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Original Articles

Preface

Miscellaneous

Acknowledgments

Original Articles

HLA and insulin-dependent diabetes: An overview

Genetic analysis of IDDM: The GAW5 multiplex family dataset

Restriction fragment polymorphisms of the HLA-DR, HLA-DQ, and insulin gene regions in IDDM: The GAW5 data

HLA class II typing using oligonucleotide probes

Immunoglobulin allotyping (Gm, Km) of GAW5 families

Coxsackie B virus assays in IDDM families: The GAW5 data on antibody prevalence

Autoantibodies to pancreatic islet cells and insulin in IDDM families: The GAW5 data

Genetic analysis of IDDM: Summary of GAW5 IDDM results

Testing genetic models for IDDM by the MASC method

The insulin gene and susceptibility to IDDM

Segregation analysis of two genetic markers in IDDM families under two-locus models

Linkage studies of HLA and insulin gene restriction fragment length polymorphisms in families with IDDM

Linkage analysis and genetic models for IDDM

Remarks on ascertainment

Charateristics of a multiplex IDDM sample: Unexplained differences with other samples

Genes predisposing to IDDM in multiplex families

Association and sibpair analysis for the HLA, Gm, Km, and insulin polymorphisms in multiplex IDDM families

HLA DR4-DQw3.1 and 3.2 haplotypes among insulin-dependent diabetics and their unaffected sibs in the GAW5 data

Clues to IDDM pathogenesis from genetic and serological traits in multiply affected families

Genetic epidemiology of persistent islet cell antibodies among IDDM patients

Statistical properties of the haplotype relative risk

Combined segregation and linkage analysis for IDDM and HLA-DR under several ascertainment assumptions

Autoimmune thyroid disease in type I diabetic families

Genetics of IDDM: Evidence for complex inheritance with HLA

HLA DQβ3.2 identifies subtypes of DR4 + haplotypes permissive for IDDM

HLA and insulin gene associations with IDDM

Genetic analysis of the affective disorders: Summary of GAW5

NIMH collaborative program on the psychobiology of depression: Clinical

Description of the National Institute of Mental Health family study of affective disorders

Description of X-linkage pedigrees

Toronto-Rochester depression study of 116 HLA-typed kindreds

Description of amish study data set

Linkage data on affective disorders in an epidemiologic context

Regressive logistic models for ordered and unordered polychotomous traits: Application to affective disorders

Age of onset, age at examination, and other covariates in the analysis of family data

Familial analysis of bipolar affective disorder using logistic models

Robustness of the unified model to shared environmental effects in the analysis of dichotomous traits

Modelling sibship environment in the regressive logistic model for familial disease

Familial correlates of risk: Application to the gershon and goldin NIMH pedigree data

The incomplete, multiple ascertainment model: Assumptions, applications, and alternative models

Performance of linkage analysis under misclassification error when the genetic model is unknown

Linkage analysis under “random” and “genetic” reduced penetrance

Affective disorders: Evaluation of a three-allele model accounting for clinical heterogeneity

Linkage analysis with cohort effects: An application to X-linkage

Linkage analysis with inbreeding

Utility of the affected sib pair method to detect linkage of a sex-linked dominant disease with a sex-linked recessive trait

Summary measures for evaluating the evidence for linkage

HLA may be involved in resistance and susceptibility to affective disorders

Affective disorder not linked to HLA

Analysis of the Toronto-Rochester depression study follow-up data confirms an HLA-region gene contribution to susceptibility to affective disorder

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