Immunoglobulin allotyping (Gm, Km) of GAW5 families

The following Gm and Km immunoglobulin allotypes were determined on the Genetic Analysis Workshop 5 insulin-dependent diabetes mellitus (GAW5 IDDM) families: Glm (1,2,3,17), G2m (23), G3m (5,10,11,13,14,21,28) and Km (1,3). Since the allotype G2m (23) has been rarely studied, due to paucity of typing reagents, it was of interest to compare the frequency of the halotype encoding this allotype in parents of North American GAW5 IDDM families with the frequency found in a previous investigation of healthy North Americans. Results indicated very similar frequencies of Gm haplotypes in the two groups.