Volume 6, Issue 1 pp. 39-41

Original Article

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Autoantibodies to pancreatic islet cells and insulin in IDDM families: The GAW5 data

Noel K. Maclaren,

Noel K. Maclaren

Department of Pathology, University of Florida College of Medicine, Gainesville, Florida

Diabetes Research Institute, Düsseldorf, Federal Republic of Germany

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William J. Riley,

William J. Riley

Department of Pathology, University of Florida College of Medicine, Gainesville, Florida

Diabetes Research Institute, Düsseldorf, Federal Republic of Germany

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David K. McCulloch,

David K. McCulloch

Diabetes Research Institute, Düsseldorf, Federal Republic of Germany

Diabetes Endocrinology Research Center, Pacific Medical Center, University of Washington, Seattle

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Dr. Jerry P. Palmer,

Corresponding Author

Dr. Jerry P. Palmer

Diabetes Research Institute, Düsseldorf, Federal Republic of Germany

Diabetes Endocrinology Research Center, Pacific Medical Center, University of Washington, Seattle

Diabetes Research Center, Pacific Medical Center—Qtrs. 8/9, 1200 12th Ave. S., Seattle, WA 98144Search for more papers by this author

Noel K. Maclaren,

Noel K. Maclaren

Department of Pathology, University of Florida College of Medicine, Gainesville, Florida

Diabetes Research Institute, Düsseldorf, Federal Republic of Germany

Search for more papers by this author

William J. Riley,

William J. Riley

Department of Pathology, University of Florida College of Medicine, Gainesville, Florida

Diabetes Research Institute, Düsseldorf, Federal Republic of Germany

Search for more papers by this author

David K. McCulloch,

David K. McCulloch

Diabetes Research Institute, Düsseldorf, Federal Republic of Germany

Diabetes Endocrinology Research Center, Pacific Medical Center, University of Washington, Seattle

Search for more papers by this author

Dr. Jerry P. Palmer,

Corresponding Author

Dr. Jerry P. Palmer

Diabetes Research Institute, Düsseldorf, Federal Republic of Germany

Diabetes Endocrinology Research Center, Pacific Medical Center, University of Washington, Seattle

Diabetes Research Center, Pacific Medical Center—Qtrs. 8/9, 1200 12th Ave. S., Seattle, WA 98144Search for more papers by this author

First published: 1989

https://doi.org/10.1002/gepi.1370060110

Citations: 3

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Abstract

Antibodies to pancreatic islet cells and insulin were studied in the Genetic Analysis Workshop 5 (GAW5) families, as indicators of an autoimmune component of pathogenesis. The rationale for these studies is summarized briefly, and references to the laboratory methods used are provided.

References

Asplin CM, Smith RF, Palmer JP (1986): Detection and quantification of insulin-binding antibodies. In WL Clarke, J Larner, SL Pohl (eds): “ Methods in Diabetic Research, Vol. 2: Clinical Methods.” New York: John Wiley and Sons, pp 693–704.
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Palmer JP, Asplin CM, Raghu PK, Clemons P, Lyen K, Tatpati O, McKnight B, Paquette T, Sperling M, Baker L, Guthrie R (1986): Anti-insulin antibodies in insulin-dependent diabetics before insulin treatment—a new marker for autoimmune B-cell damage? Pediatr Adolesc Endocrinol 15: 111–116.
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Srikanta S, Ricker AT, McCulloch DK, Soeldner JS, Eisenbarth GS, Palmer JP (1986): Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus. Diabetes 35: 139–142.
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Citing Literature

Volume6, Issue1

Special Issue:Genetic Analysis of Complex trait: Insulin‐Department Diabetes Mellitus and Affective Disorders

1989

Pages 39-41

Autoantibodies to pancreatic islet cells and insulin in IDDM families: The GAW5 data

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References

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Autoantibodies to pancreatic islet cells and insulin in IDDM families: The GAW5 data

Abstract

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