Genetic analysis of IDDM: The GAW5 multiplex family dataset
Corresponding Author
Dr. M. P. Baur
Institute for Medical Statistics, Documentation and Data Processing, University of Bonn, Bonn, Federal Republic of Germany
Institut für Medizinische Statistik, Sigmund-Freud-Str. 25, 5300 Bonn, Federal Republic of GermanySearch for more papers by this authorR. Fimmers
Institute for Medical Statistics, Documentation and Data Processing, University of Bonn, Bonn, Federal Republic of Germany
Search for more papers by this authorC. Fritsche
Institute for Medical Statistics, Documentation and Data Processing, University of Bonn, Bonn, Federal Republic of Germany
Search for more papers by this authorM. Hümmelink
Institute for Medical Statistics, Documentation and Data Processing, University of Bonn, Bonn, Federal Republic of Germany
Search for more papers by this authorM. Neugebauer
Institute for Medical Statistics, Documentation and Data Processing, University of Bonn, Bonn, Federal Republic of Germany
Search for more papers by this authorR. T. Acton
Institute for Medical Statistics, Documentation and Data Processing, University of Alabama, Birmingham
Search for more papers by this authorT. Hodge
Institute for Medical Statistics, Documentation and Data Processing, University of Alabama, Birmingham
Search for more papers by this authorJ. Barbosa
Institute for Medical Statistics, Documentation and Data Processing, University of Minnesota Medical School, Minneapolis
Search for more papers by this authorJ. Bertrams
Diabetes Research Institute, Düsseldorf, Federal Republic of Germany
Search for more papers by this authorK. Fehsel
Diabetes Research Institute, Düsseldorf, Federal Republic of Germany
Search for more papers by this authorH. Kolb
Diabetes Research Institute, Düsseldorf, Federal Republic of Germany
Search for more papers by this authorH. Rothe
Diabetes Research Institute, Düsseldorf, Federal Republic of Germany
Search for more papers by this authorB. Boehm
Klinikum der Johann W. Goethe Universität, Frankfurt, Federal Republic of Germany
Search for more papers by this authorE. Colle
Montreal Children's Hospital, Montreal, Quebec, Canada
Search for more papers by this authorM. J. MacDonald
University of Wisconsin Medical School, Madison
Search for more papers by this authorJ. L. Gottschall
Blood Center of Southeastern Wisconsin, Milwaukee
Search for more papers by this authorJ. I. Rotter
Cedars-Sinai Medical Center, Los Angeles, California
Search for more papers by this authorC. Vadheim
Cedars-Sinai Medical Center, Los Angeles, California
Search for more papers by this authorC. Rittner
Institut f. Rechtsmedizin, Universität Mainz, Mainz, Federal Republic of Germany
Search for more papers by this authorP. Schneider
Institut f. Rechtsmedizin, Universität Mainz, Mainz, Federal Republic of Germany
Search for more papers by this authorN. J. Cox
University of Pennsylvania School of Medicine Philadelphia
Search for more papers by this authorL. Baker
University of Pennsylvania School of Medicine Philadelphia
Search for more papers by this authorR. S. Spielman
University of Pennsylvania School of Medicine Philadelphia
Search for more papers by this authorCorresponding Author
Dr. M. P. Baur
Institute for Medical Statistics, Documentation and Data Processing, University of Bonn, Bonn, Federal Republic of Germany
Institut für Medizinische Statistik, Sigmund-Freud-Str. 25, 5300 Bonn, Federal Republic of GermanySearch for more papers by this authorR. Fimmers
Institute for Medical Statistics, Documentation and Data Processing, University of Bonn, Bonn, Federal Republic of Germany
Search for more papers by this authorC. Fritsche
Institute for Medical Statistics, Documentation and Data Processing, University of Bonn, Bonn, Federal Republic of Germany
Search for more papers by this authorM. Hümmelink
Institute for Medical Statistics, Documentation and Data Processing, University of Bonn, Bonn, Federal Republic of Germany
Search for more papers by this authorM. Neugebauer
Institute for Medical Statistics, Documentation and Data Processing, University of Bonn, Bonn, Federal Republic of Germany
Search for more papers by this authorR. T. Acton
Institute for Medical Statistics, Documentation and Data Processing, University of Alabama, Birmingham
Search for more papers by this authorT. Hodge
Institute for Medical Statistics, Documentation and Data Processing, University of Alabama, Birmingham
Search for more papers by this authorJ. Barbosa
Institute for Medical Statistics, Documentation and Data Processing, University of Minnesota Medical School, Minneapolis
Search for more papers by this authorJ. Bertrams
Diabetes Research Institute, Düsseldorf, Federal Republic of Germany
Search for more papers by this authorK. Fehsel
Diabetes Research Institute, Düsseldorf, Federal Republic of Germany
Search for more papers by this authorH. Kolb
Diabetes Research Institute, Düsseldorf, Federal Republic of Germany
Search for more papers by this authorH. Rothe
Diabetes Research Institute, Düsseldorf, Federal Republic of Germany
Search for more papers by this authorB. Boehm
Klinikum der Johann W. Goethe Universität, Frankfurt, Federal Republic of Germany
Search for more papers by this authorE. Colle
Montreal Children's Hospital, Montreal, Quebec, Canada
Search for more papers by this authorM. J. MacDonald
University of Wisconsin Medical School, Madison
Search for more papers by this authorJ. L. Gottschall
Blood Center of Southeastern Wisconsin, Milwaukee
Search for more papers by this authorJ. I. Rotter
Cedars-Sinai Medical Center, Los Angeles, California
Search for more papers by this authorC. Vadheim
Cedars-Sinai Medical Center, Los Angeles, California
Search for more papers by this authorC. Rittner
Institut f. Rechtsmedizin, Universität Mainz, Mainz, Federal Republic of Germany
Search for more papers by this authorP. Schneider
Institut f. Rechtsmedizin, Universität Mainz, Mainz, Federal Republic of Germany
Search for more papers by this authorN. J. Cox
University of Pennsylvania School of Medicine Philadelphia
Search for more papers by this authorL. Baker
University of Pennsylvania School of Medicine Philadelphia
Search for more papers by this authorR. S. Spielman
University of Pennsylvania School of Medicine Philadelphia
Search for more papers by this authorAbstract
In a collaborative effort by 12 centers from Europe and North America, data were assembled from 94 multiplex families with insulin-dependent diabetes mellitus (IDDM) for analysis of genetic and other factors of possible etiological importance. The dataset contains information on the following genetic markers: HLA-DRß and -DQß restriction fragment length polymorphisms (RFLPs), three RFLPs detected with two probes that map 5′ to the insulin gene, the serologically defined HLA loci, and the immunoglobulin allotypes. Data also were included for auto-antibodies to insulin and pancreatic islet cells as possible indicators of pathogenesis and for antibodies to certain viruses that have been implicated as “triggering” agents in IDDM. Medical histroy of family members was obtained by means of a uniform questionnaire. Identical copies of the dataset were distributed to anyone wishing to participate in the analysis for the IDDM component of GAW5. The multiplex IDDM family dataset is now available on request for further analysis.
References
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