Original Article
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Linkage data on affective disorders in an epidemiologic context
Dr. Elliot S. Gershon,
Lynn R. Goldin,
Corresponding Author
Dr. Elliot S. Gershon
Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland
Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, MD 20892Search for more papers by this authorLynn R. Goldin
Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland
Search for more papers by this authorDr. Elliot S. Gershon,
Lynn R. Goldin,
Corresponding Author
Dr. Elliot S. Gershon
Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland
Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, MD 20892Search for more papers by this authorLynn R. Goldin
Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland
Search for more papers by this authorAbstract
Recent data on chromosomal linkage markers in affective disorders indicate that single locus inheritance is involved in these disorders. The presence of a single locus has not been detectable using segregation analysis on family study data from large populations, possibly because of both heterogeneity and birth cohort and sex differences in diagnostic frequencies.
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