Restriction fragment polymorphisms of the HLA-DR, HLA-DQ, and insulin gene regions in IDDM: The GAW5 data
N. J. Cox
University of Pennsylvania School of Medicine, Philadelphia
Search for more papers by this authorK. J. Gogolin
University of Pennsylvania School of Medicine, Philadelphia
Search for more papers by this authorV. J. Horvath
University of Pennsylvania School of Medicine, Philadelphia
Search for more papers by this authorD. F. Barker
University of Utah School of Medicine, Salt Lake City
Search for more papers by this authorE. Wright
University of Utah School of Medicine, Salt Lake City
Search for more papers by this authorM. H. Skolnick
University of Utah School of Medicine, Salt Lake City
Search for more papers by this authorB. O. Boehm
Klinikum der Johann W. Goethe Universität, Frankfurt, Federal Republic of Germany
Search for more papers by this authorK. Fehsel
Diabetes Research Institute, Düsseldorf, Federal Republic of Germany
Search for more papers by this authorJ. Bertrams
Diabetes Research Institute, Düsseldorf, Federal Republic of Germany
Search for more papers by this authorS. C. Elbein
University of Utah School of Medicine, Salt Lake City
Search for more papers by this authorM. A. Permutt
Washington University School of Medicine, St. Louis
Search for more papers by this authorP. M. Schneider
Institut f. Rechtsmedizin, Universität Mainz, Mainz, Federal Republic of Germany
Search for more papers by this authorC. Rittner
Institut f. Rechtsmedizin, Universität Mainz, Mainz, Federal Republic of Germany
Search for more papers by this authorCorresponding Author
Dr. R. Spielman
University of Pennsylvania School of Medicine, Philadelphia
Department of Human Genetics, 196 John Morgan Building, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6072Search for more papers by this authorN. J. Cox
University of Pennsylvania School of Medicine, Philadelphia
Search for more papers by this authorK. J. Gogolin
University of Pennsylvania School of Medicine, Philadelphia
Search for more papers by this authorV. J. Horvath
University of Pennsylvania School of Medicine, Philadelphia
Search for more papers by this authorD. F. Barker
University of Utah School of Medicine, Salt Lake City
Search for more papers by this authorE. Wright
University of Utah School of Medicine, Salt Lake City
Search for more papers by this authorM. H. Skolnick
University of Utah School of Medicine, Salt Lake City
Search for more papers by this authorB. O. Boehm
Klinikum der Johann W. Goethe Universität, Frankfurt, Federal Republic of Germany
Search for more papers by this authorK. Fehsel
Diabetes Research Institute, Düsseldorf, Federal Republic of Germany
Search for more papers by this authorJ. Bertrams
Diabetes Research Institute, Düsseldorf, Federal Republic of Germany
Search for more papers by this authorS. C. Elbein
University of Utah School of Medicine, Salt Lake City
Search for more papers by this authorM. A. Permutt
Washington University School of Medicine, St. Louis
Search for more papers by this authorP. M. Schneider
Institut f. Rechtsmedizin, Universität Mainz, Mainz, Federal Republic of Germany
Search for more papers by this authorC. Rittner
Institut f. Rechtsmedizin, Universität Mainz, Mainz, Federal Republic of Germany
Search for more papers by this authorCorresponding Author
Dr. R. Spielman
University of Pennsylvania School of Medicine, Philadelphia
Department of Human Genetics, 196 John Morgan Building, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6072Search for more papers by this authorAbstract
The primary aim of the insulin-dependent diabetes mellitus (IDDM) component of Genetic Analysis Workshop 5 (GAW5) was to collect and analyze new data on DNA polymorphisms closely linked to the HLA-D region and the insulin gene. The probes and restriction enzymes described here were used by all ten participating labs, and the data from Southern blotting were interpreted and reported according to conventions developed for the Workshop. These DNA data on members of 94 families with two or more IDDM sibs constitute the largest such sample available. The data were used in most of the analyses presented at the Workshop meeting, and are available on request.
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