Pediatric Transplantation

En bloc lung transplantation (EBLT) does not confer a survival advantage over bilateral sequential technique in the pediatric population. EBLT patients are less likely to develop airway ischemia and bronchiolitis obliterans syndrome. EBLT was also not found to be advantageous in the subgroup of patients <= 5 years of age.

We review design elements that help to improve engagement (in a particularly hard-to-engage cohort) and reduce attrition, discuss the tailoring paradigm that uses biomarker readings to modify aspects of the manual-driven protocol, and present considerations for designing remote interventions that engage patients across state lines.

Pediatric males experienced relative protection from acute rejection in liver, lung, and kidney transplantation compared to their female counterparts in our study. This analysis helps clarify the role of recipient sex as a nonmodifiable risk factor for acute rejection and assists clinicians in stratifying risk and personalizing immunosuppression regimens.

Intellectual disability does not impact long-term outcomes after bilateral lung transplantation and should not be a contraindication to transplantation on the basis of inferior graft survival.

An antifungal regimen of micafungin and nebulized amphotericin B liposomal may be useful at decreasing the duration of elevated liver enzymes in pediatric patients in the immediate post-lung transplant period when compared to voriconazole monotherapy.

Representative computed tomography (CT) and chest X-ray (CXR) segmentations of a single subject used in determining the correlations between CT lung volumes and CXR measurements. These correlations allow for the accurate determination of anatomical lung volume based on a single CXR.