Extracorporeal membrane oxygenation and paracorporeal lung assist devices as a bridge to pediatric lung transplantation
Laura E. Chiel
Division of Pulmonary Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorZachary A. Winthrop
Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorFrancis Fynn-Thompson
Department of Cardiac Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorCorresponding Author
Levent Midyat
Division of Pulmonary Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Correspondence
Levent Midyat, Division of Pulmonary Medicine, Boston Children’s Hospital, 300 Longwood Avenue, BCH 3121, Boston, MA, 02115, USA.
Email: [email protected]
Search for more papers by this authorLaura E. Chiel
Division of Pulmonary Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorZachary A. Winthrop
Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorFrancis Fynn-Thompson
Department of Cardiac Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorCorresponding Author
Levent Midyat
Division of Pulmonary Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Correspondence
Levent Midyat, Division of Pulmonary Medicine, Boston Children’s Hospital, 300 Longwood Avenue, BCH 3121, Boston, MA, 02115, USA.
Email: [email protected]
Search for more papers by this authorAbstract
Background
“Bridging” is a term used to describe the implementation of various treatment modalities to improve waitlist survival while a patient awaits lung transplantation. ECMO and PLAD are technologies used to bridge patients to lung transplantation. ECMO and PLAD are cardiopulmonary support systems that help move blood forward while using an artificial membrane to remove CO2 from and add O2 to the blood. Recent studies showed that these technologies are increasingly effective in bridging patients to lung transplantation, especially with optimizing patient selection, implementing physical rehabilitation and ambulation goals, standardization of management decisions, and increasing staff experience, among other considerations. We review these technologies, their roles as bridges to pediatric lung transplantation, as well as indications, contraindications, complications, and mortality rates.
Conclusion
Finally, we discuss the existing knowledge gaps and areas for future research to improve patient outcomes and understanding of lung assist devices.
CONFLICT OF INTEREST
The other authors have indicated they have no potential conflicts of interest to disclose.
Open Research
DATA AVAILABILITY STATEMENT
There is no data statement for this review article.
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