This review mainly describes the cellular immunological features of COVID-19, including an uncontrolled innate immune response leading to cytokine storm, and severe lymphopenia and exhaustion of T cells. The potential COVID-19 immunotherapeutic approaches mainly targeting at blocking inflammatory cytokines and restoring immune cell function have been extensively investigated with many ongoing clinical trials.

Phylogenies of Cyperaceae, Juncaceae, and their rusts (Pucciniaceae) are congruent, despite few cospeciation events, suggesting that preferential host jumps generated the cophylogenetic signal. Host diversification may have promoted parasite diversification, given the temporal congruence between the origin of major Carex clades and their rusts. This large DNA barcoding effort (252 sequences, 82 taxa) also uncovered many potential cryptic species.

The contents of this page will be used as part of the graphical abstract of html only. It will not be published as part of main article.In-cellulo effect of G-Quadruplex stabilization in cancer cells.

A precision diagnostic platform integrating genomics and transcriptomics with drug testing of patient's primary tumor cells in high throughput drug screening (HTS) and patient-derived xenograft (PDX) was established to improve identification of therapies in high-risk pediatric cancer patients.

Analyses of potential prodrug failure mechanisms show that prodrugs that rely on pathogen-specific pathways for conversion are susceptible to competing rates of prodrug activation and bacterial replication, which could lead to prodrug treatment escape and failure.

Nanomedicines combining different strategies with chemotherapy for combating MDR.